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Aricept Evess has the main ingredient donepezil hydrochloride, used in the symptomatic treatment of Alzheimer's disease and dementia in cerebrovascular disease. To ensure the effectiveness of treatment and avoid side effects, users need to strictly follow the instructions of the doctor, professional pharmacist.
1. Uses of Aricept Evess
Aricept Evess is a psychotropic drug, made in the form of tablets that dissolve in the mouth and the main wall of the drug is Donepezil hydrochloride.
Aricept Evess 5mg, Aricept Evess 10mg is indicated for prescription in the following cases:
Treatment of Alzheimer's disease:
Mild to moderate: Use Aricept Evess for this group of patients with a dose of 5mg /dose/day or 10mg/dose/day produced a steady-state inhibition of acetylcholinesterase activity (measured in erythrocyte membranes) of 63.6% and 77.3%, respectively, when dosed. At severe level: For patients with severe Alzheimer's disease, treatment with Aricept Evess is effective. This was investigated in 3 placebo-controlled trials of 6 months duration. Treatment of vascular dementia:
Through the results of 3 6-month placebo-controlled trials, Aricept Evess is effective in the treatment of vascular dementia blood. Among them is the diagnostic criteria for vascular dementia according to the group of the National Institute of Neurological Disorders and Stroke - International Association for the Research and Teaching of Neuroscience (NINDS-AIREN). used to identify the study group of patients. When all 3 efficacy criteria were combined, an analysis was conducted to reach a conclusion regarding donepezil treatment. The percentage of patients responding to treatment after taking Aricept Evess was demonstrated by a statistically significant increase in the rate.
2. Contraindications of Aricept Evess
Aricept Evess is contraindicated in the following cases:
Patients with hypersensitivity to the component donepezil hydrochloride, piperidine derivatives, or any of the excipients included in the drug formulation; Not indicated for use by pregnant and breastfeeding women.
3. Dosage of Aricept Evess
Dosage for adults and the elderly:
The recommended dose at the beginning of treatment is 5mg/dose/day. Patients need to use Aricept Evess orally and take it at night before going to bed. Accordingly, take the drug by placing the tablet on the tongue and allowing the tablet to dissolve in the mouth before swallowing or drinking with water. The duration of treatment with 5 mg/dose/day should be maintained for at least 1 month, then assess clinical response to treatment as soon as possible and assess donepezil hydrochloride concentrations already in stable yet. Aricept Evess dose can be increased to 10mg/dose/day and this is the maximum dose allowed in 1 day. Doses greater than 10 mg/dose/day have not been studied in clinical trials.
The beneficial effects of Aricept Evess may diminish if the patient discontinues use. There have been no signs of a rebound effect if treatment is stopped abruptly.
Dosage for children: Aricept Evess is not indicated for use in children. Dosage for other populations: Patients with hepatic impairment, renal failure can receive the same treatment regimen, because the status of liver failure or renal failure does not affect the clearance of donepezil hydrochloride. Dosage should be adjusted according to individual patient tolerance, as there may be significant changes in mild to moderate hepatic impairment. There are no data available in patients with severe hepatic impairment.
4. Unwanted effects when using Aricept Evess
During the use of Aricept Evess, patients may experience some side effects (ADRs) such as:
The most common side effect during treatment with Aricept Evess is diarrhea, spasticity. muscles, feeling tired, nausea and vomiting, insomnia. Side effects for severe Alzheimer's disease have been similar to those for mild to moderate Alzheimer's disease. The following statistics reflect the frequency of adverse events in patients being treated with Aricept Evess 5Mg at all stages of Alzheimer's disease:
Very common side effects, ADR >1/10
Digestive disorders Chemical: Diarrhea, nausea; General condition: Feeling headache. Common side effects, ADR >1/100
Infectious and parasitic diseases: Common cold; Psychiatric disorders: Hallucinations, agitation, aggressive behavior; Nervous system disorders: Fainting, feeling light-headed, insomnia; Digestive disorders: Vomiting, abdominal disorders; Skin and subcutaneous tissue disorders: Rash, itching; Musculoskeletal, connective tissue and bone disorders: Muscle spasticity; Renal and urinary disorders: Urinary incontinence; General condition: Loss of fatigue, pain; Other Injury and Poisoning: Accident. Rare side effects, 1/1000 < ADR < 1/100
Nervous system disorders: Epilepsy ; Heart disorders: Slows the heart rate; Digestive disorders: Gastrointestinal bleeding, peptic ulcer; Blood tests: Slight increase in creatine kinase levels in the blood. Very rare side effects, 1/10000 < ADR < 1/1000
Nervous system disorders: Extrapyramidal symptoms; Heart disorders: Sinus atrioventricular block, atrioventricular block; Liver and biliary disorders: Liver dysfunction, even hepatitis. How to deal with ADR:
During the treatment with Aricept Evess, if you encounter unwanted effects, you should first deal with it by informing the treating doctor about the condition you are experiencing for guidance. solution.
Cases of hallucinations, excitability, and aggressive behavior can be improved by reducing the dose, and in cases of unexplained liver dysfunction, treatment discontinuation should be considered. treat.
Aricept Evess has the main ingredient donepezil hydrochloride, used in the symptomatic treatment of Alzheimer's disease and dementia in cerebrovascular disease. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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