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Antricar drug with the main ingredient is Trimetazidine hydrochloride 20mg, the drug is used in the prevention of angina pectoris. Learn more about the use of Antricar in the article below.
1. What is Antricar?
Antricar has the main ingredient Trimetazidine hydrochloride 20mg, used for the symptomatic treatment of stable angina (chest pain). Angina pectoris is a symptom of ischemic heart disease. Myocardial ischemia has several metabolic consequences: Production and storage of acid metabolites, leading to intracellular acidosis, decreased intracellular concentrations of adenosine triphosphate (ATP) and phosphocreatine, accumulation of acids free fatty acids and generate oxygen free radicals. This can lead to cell loss and ultimately a poor prognosis. Common agents have hemodynamic effects to restore the imbalance between myocardial oxygen supply and demand. Antricar (2,3,4 trimethoxybenzyl-piperazine dihydrochloride) is a novel anti-ischemic compound belonging to the class of cytoprotective drugs. It represents a cellular approach to ischemia by directly combating all major metabolic abnormalities occurring in ischemic cells.
2. Indications of the drug Antricar
Antricar is indicated in the treatment of:
Prophylaxis of angina pectoris. Treatment of damage to blood vessels in the retina, vasomotor vertigo, Ménière's syndrome, tinnitus.
3. How to take Anticar
Recommended dose of Antricar for angina prophylaxis: 20mg 3 times daily with meals. Antricar can be combined with calcium channel blockers or β-blockers. Impaired Liver and Renal Function: No dosage adjustment is required in patients with impaired hepatic and renal function.
4. Contraindications of the drug Antricar
Antricar is contraindicated in the following cases:
Hypersensitivity to any active ingredient of the drug. Parkinson's patients, patients with Parkinson's symptoms, restless legs syndrome and other related movement disorders. Patients with severe renal impairment (creatinine clearance < 30 ml/min).
5. Drug side effects of the drug Antricar
In general, Antricar is well tolerated. The most common side effects were stomach upset, nausea, headache, and dizziness. In general, adverse events are mild and reversible upon discontinuation of treatment.
6. Be careful when using Antricar
Avoid use of Antricar during pregnancy and lactation due to limited clinical data of trimetazidine.
Antricar may cause or worsen Parkinson's symptoms (tremor, bradykinesia, difficulty, increased muscle tone). Therefore, patients, especially the elderly, need to be monitored regularly.
If the patient experiences movement disorders such as Parkinson's symptoms, tremors, restless legs syndrome, the drug should be stopped immediately. These cases are usually reversible after stopping the drug about 4 months. If Parkinson's symptoms continue to occur more than 4 months after stopping the drug, the patient should see a neurologist.
Patients taking Antricar may experience falls, unsteady gait or hypotension, especially in those taking antihypertensive drugs.
Care should be taken when administering Antricar to patients with high sensitivity such as:
People with moderate renal impairment. Elderly people over 75 years old.
7. Drug interactions
No drug interactions have been reported between Antricar and beta-blockers, calcium antagonists, nitrates, heparin, antidiabetic agents or digitalis preparations.
Antricar drug with the main ingredient is Trimetazidine hydrochloride 20mg, the drug is used in the prevention of angina pectoris. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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