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Angina is chest pain as a result of transient myocardial ischemia, which can be caused by atherosclerotic plaques, coronary artery disease, and aortic stenosis. At that time, patients are usually prescribed Nicorandil. One of the drugs containing this active ingredient is Nicomen 5mg.
1. What is Nicomen 5mg?
What is nicotine? Nicomen 5mg is a drug manufactured by Standard Chem & Pharm. Co., Ltd., with the main ingredient Nicorandil 5mg and excipient system including: Inositol, Calcium stearate, starch 1500, Mannitol, Calcium carboxymethyl cellulose.
Nicorandil is an active ingredient that works by relaxing vascular smooth muscle, especially the venous system through 2 different pathways, first it works by activating potassium channels, then providing Nitric Oxide to Guanylate cyclase activates the enzyme Guanylate cyclase, and Guanylate cyclase activates GMP leading to both venous and arterial vasodilation.
Because Nicorandil acts selectively on vascular potassium channels, Nicorandil has no significant effect on myocardial contractility and conduction. Nicorandil can dilate coronary arteries in healthy subjects, but Nicorandil has little effect on coronary arteries in people with myocardial infarction. Instead, Nicorandil dilates the venous system, reducing the amount of blood flowing to the heart, thereby reducing the work of the heart.
Nicorandil is very well absorbed, does not undergo first-pass metabolism in the liver and reaches maximum plasma concentrations after 30-60 minutes. Approximately 20% of a dose of Nicorandil is excreted in the urine as metabolites and the elimination half-life is about 1 hour.
2. What disease does Nicomen 5mg treat?
Nicomen 5mg is a medicine used to treat angina pectoris.
3. Dosage of Nicomen 5mg
Nicomen 5mg is used orally with the following dosage:
Adults: Initially use 10mg x 2 times / day or 5mg x 2 times / day for patients prone to headaches, then the dose of Nicomen 5mg will gradually adjusted according to the clinical response of the patient. The usual dose of nicotine 5mg is 10-20mg x 2 times/day. The maximum dose of nicotine 5mg is 30mg x 2 times/day. Elderly: It is not necessary to reduce the dose of Nicomen 5mg in the elderly, but the lowest effective dose should be used. Children: Nicomen 5mg is not recommended for children. Note: The above dose of Nicomen 5mg is for reference only, the specific dose depends on the condition and progression of the disease, patients need to consult a doctor or medical professional before using it. Use nicotine 5mg.
4. What to do when overdose Nicomen 5mg?
Monitor cardiac function and apply general supportive measures in case of overdose of Nicomen 5mg, if necessary, plasma volume can be increased by using appropriate infusion fluids. In life-threatening cases of nicotine 5mg overdose, the use of vasoconstrictor agents may be considered.
5. Side effects of Nicomen 5mg
When using Nicomen 5mg, patients may experience unwanted effects as follows:
Common side effects of Nicomen 5mg: Transient headache at the beginning of treatment, dizziness, nausea, vomiting; dilation of skin blood vessels causing facial flushing; feel weak. Less common side effects of Nicomen 5mg: Increased heart rate when taking high doses. Rare side effects of Nicomen 5mg drug: Pressure sores or sores in the mouth for a long time, liver dysfunction, erythema, muscle pain. Side effects of Nicomen 5mg are very rare: angioedema, gastrointestinal ulceration. When experiencing side effects of Nicomen 5mg, the patient should stop using and notify the doctor immediately or go to the nearest medical facility for medical staff to assist in timely handling.
6. Contraindications of Nicomen 5mg
Nicomen 5mg is contraindicated for use in the following cases:
Cardiogenic shock; Left ventricular failure; Hypotension; Hypersensitivity to ingredients Nicorandil; Concomitant use of Nicomen 5mg with phosphodiesterase 5 inhibitors (sildenafil, tadalafil, vardenafil).
7. Caution when using Nicomen 5mg
Nicomen 5mg should be avoided in patients with hypovolemia, low systolic blood pressure, acute pulmonary edema or acute myocardial infarction, acute left ventricular failure, low blood pressure to the heart. Therapeutic doses of Nicorandil may lower blood pressure in hypertensive patients, therefore Nicorandil should be used with caution when prescribing concomitantly with other antihypertensive agents. There have been reports of gastrointestinal ulcers, mucosal ulcers when using Nicorandil in Nicomen 5mg. Substitute Nicomen 5mg should be considered when the patient has aphthous disease or severe oral ulceration. Gastrointestinal perforation has also been reported with the use of Nicorandil, concomitantly with corticosteroids, and caution should be exercised when Nicomen 5mg is combined with these agents. Nicotine 5mg must be used with caution in hypovolemic patients or in patients with acute pulmonary edema. Warning patients taking Nicomen 5mg should not drive or operate machinery until it is known that their actions are not affected by Nicorandil. Animal studies have not revealed harmful effects of Nicorandil on the fetus, however, since no studies have been conducted in humans, nicotine 5mg should not be administered to pregnant patients unless there is no safe option. more complete. It is not known whether Nicorandil is secreted into breast milk, Nicomen 5mg should be avoided in nursing patients.
8. Nicomen 5mg . Drug Interactions
No pharmacodynamic or pharmacokinetic interactions of Nicomen 5mg with beta-blockers, digoxin, rifampicin, cimetidine, acenocoumarol, calcium antagonists or the combination of digoxin and furosemide have been observed in humans or animals. However, Nicorandil has the potential to increase the antihypertensive effect of vasodilators, tricyclic antidepressants. The hypotensive effect of nitrates or nitric oxide suppliers is enhanced by Phosphodiesterase 5 inhibitors, so the concomitant use of Nicomen 5mg with Phosphodiesterase 5 inhibitors is contraindicated. Nicomen 5mg is a manufactured drug. Produced by Standard Chem & Pharm. Co., Ltd., with the main ingredient Nicorandil 5mg. The drug is indicated for the treatment of angina pectoris. To ensure effectiveness and avoid unwanted side effects, patients need to take the drug according to a prescription or consult a doctor, professional pharmacist.
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