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Nicorandil 5mg is classified as a vasodilator and anti-anginal drug thanks to its ability to open calcium channels to dilate arterioles and large coronary arteries. Not only that, the nitrate group can dilate veins when stimulating guanylate cyclase.
1. What is Nicorandil 5mg?
Nicorandil 5mg drug has the international name Nicorandil, is classified in the group of antianginal and vasodilator drugs. The drug is prepared in the form of tablets, ampoules and vials of 0.2g powder for intravenous solution.
Nicorandil 5mg drug can be well absorbed from the gastrointestinal tract. After 30-60 minutes of oral administration, the concentration of the drug can peak in the plasma, about 20% of the drug is metabolized and excreted in the urine, the total half-life is about 1 hour.
2. Effects of the drug Nicorandil 5mg
Nicorandil medicine 5mg is commonly used to treat angina pectoris and dilate blood vessels. In addition, this drug also has the ability to increase blood and oxygen to the heart and relieve pain, thereby preventing the development of heart disease.
The drug also has some other effects that are not listed on the package but have been approved. Therefore your doctor may still ask you to use this medicine. This is a prescription drug, so it should only be used when prescribed by a doctor.
Thuốc Nicorandil được dùng trong điều trị các cơn đau thắt ngực
3. Dosage of nicorandil 5mg for each subject
3.1. Prevention of acute coronary events Patients with acute coronary artery disease are indicated to take tablets, administered orally. The dosage may change according to the length of time the drug is taken. The initial dose, the patient takes 10mg, orally twice a day. For headache-prone cases, the dose should be reduced to 5 mg. If necessary, it can be increased to 30mg, twice a day. With continuous dosing, patients use 10 to 20 mg, twice a day.
3.2. Patients with unstable angina Patients with angina use the drug in the form of intravenous infusion, the dose is 20mg with a solution containing 100 to 300 micrograms/ml. The doctor can adjust the dosage according to the patient's condition to eat up to 6mg/hour.
3.3. Patients with acute heart failure and acute decompensated chronic heart failure Use a solution containing 400 to 2500 micrograms/ml at a dose of 200 micrograms/kg for intravenous infusion over 5 minutes. Then switch continuously at a dose of 200 micrograms/kg/hour. Adjust the dose to suit the course of the disease, but not more than 200 micrograms/kg/hour. To dilute the drug can use 0.9% sodium chloride solution or 5% Glucose solution. In elderly patients with renal impairment, no dosage adjustment is required as the pharmacokinetics of the drug are not significantly altered in these subjects. In cirrhotic patients, the elimination half-lives are higher than in the general population, but they do not significantly affect the clinical response.
4. Some unwanted side effects of nicorandil 5mg
Like other drugs, nicorandil 5mg still has the possibility of some side effects during use. Common symptoms include:
Headache often appears in the early stages of treatment, patients have transient pain. Redness of the face Vasodilation under the skin Nausea Vomiting Dizziness Fatigue Less common symptoms:
Mouth ulcers: Common in people taking high doses and appearing late Muscle pain Rash, skin redness Very rare symptoms:
Angioedema Liver dysfunction Decrease blood pressure Increase heart rate Measures when side effects appear
When symptoms of anal ulcer persist, you need to stop using the drug. To minimize the frequency of headaches at the beginning of treatment, you can increase the dose gradually. Usually the symptoms of lowering blood pressure and heart rate increase steadily because of high efficiency, so you can reduce the dose to improve this condition.
Rối loạn nhịp tim là một trong các tác dụng của thuốc Nicorandil 5mg
5. Cases needing caution when using nicorandil 5mg
Patients with recent myocardial infarction, low blood pressure, inflammatory heart disease have hemodynamic disorders because when using the drug can make blood pressure worse or cause anemia. Patients with traumatic brain injury, cerebral hemorrhage. Pregnant women. Women are breastfeeding. You are allergic to some ingredients in the drug The patient is in the process of using other drugs such as: Vitamins, functional foods, prescription drugs, ... Pulmonary edema In addition to the effects While nicorandil can be used, they also have unwanted side effects. Therefore, before deciding to use any medicine, you should research carefully and consult with your doctor and experts.
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