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Amikacin medicine 125mg/ml has the main active ingredient Amikacin sulfate and other excipients in a sufficient amount. This is a drug to treat infections in adults and children caused by susceptible gram-negative and gram-positive bacteria, respiratory and urinary tract infections.
1. What is Amikacin 125mg/ml?
Amikacin medicine 125mg/ml has the main active ingredient Amikacin sulfate and other excipients in sufficient quantity. Amikacin medicine 125mg/ml belongs to the group of antibiotics Aminoglycoside, anti-parasitic, anti-infective, antiviral and antifungal. Amikacin 125mg/ml is prepared in the form of an injectable solution, the package specification is a box of 10 ampoules, each containing 2ml. This drug is used to treat infections in adults and children caused by susceptible gram-negative and gram-positive bacteria, respiratory tract and urinary tract infections.
1.1. Pharmacokinetics of Amikacin 125mg/ml Absorption: Amikacin 125mg/ml is rapidly absorbed, peak concentrations are reached after 30 minutes to 1 hour. Distribution: Amikacin 125mg/ml penetrates well into bone, heart, urinary tract, lung tissue, biliary tract, bronchi, pus, intercellular spaces, pleural space and synovial space. The drug has poor penetration into the cerebrospinal fluid but is significantly increased when the meninges are inflamed. Excretion capacity: Mainly through glomerular filtration. Therefore, when using Amikacin 125mg/ml for people with renal failure, it is necessary to monitor very carefully. 1.2. Effects of Amikacin 125mg/ml Amikacin 125mg/ml is effective against many types of bacteria, specifically as follows:
Gram (-): The following types of bacteria are sensitive in vitro to Amikacin active ingredient: Pseudomonas sp., Escherichia coli, Proteus sp. (indole positive and negative), Providencia sp., Enterobacter sp., Serratia sp., Klebsiella sp., Acinetobacter sp., Citrobacter freundii. These strains of bacteria are resistant to specific Aminoglycosides such as Gentamycin, Tobramycin, Kanamycin, but in vitro they are sensitive to the active ingredient Amikacin. Gram (+): Penicillinase-producing and non-penicillinase-producing staphylococci, including in vitro methicillin-resistant staphylococci, are sensitive to amikacin. Other gram (+) bacteria that are less sensitive to the aminoglycoside group include: streptococci, pneumococcus or enterococci.
2. What disease does Amikacin 125mg/ml treat?
Amikacin 125mg/ml is used in the treatment of the following diseases:
Treatment of infections caused by susceptible Gram-negative and Gram-positive bacteria, including Pseudomonas sp. Treatment of respiratory tract, urinary tract, abdominal and gynecological infections, blood infections, bone and joint infections, skin and skin structure infections. Amikacin is indicated for short-term treatment of serious infections caused by susceptible strains of Pseudomonas sp., Escherichia coli, Proteus sp., Enterobacter sp., Serratia sp., Acinetobacter sp., Klebsiella sp. ., Citrobacter freundii. Clinical studies have shown that Amikacin is effective in bacteremia including neonatal sepsis, severe infections of the respiratory tract, bones and joints, central nervous system including meningitis, skin and soft tissue infections, intra-abdominal infections including peritonitis, burn infections, and postoperative infections. Amikacin 125mg/ml is also effective in severe complications and recurrent urinary tract infections caused by the bacteria mentioned above. Should be combined with antibiotics of the beta-lactam family for optimal effect.
3. Usage and dosage of Amikacin 125mg/ml
Intramuscular: For adults, older children and young children with normal renal function: 15 mg/kg body weight/day in divided doses approximately 8 to 12 hours apart. The total daily therapeutic dose for adults should not exceed 1.5 g. Intravenous injection: The therapeutic dose is similar to the intramuscular dose. Using the drug by intravenous route, the solution should be injected slowly over 2-3 minutes. If intravenous infusion, the solution should be infused over a period of 30 to 60 minutes for adults and 1-2 hours for children.
4. Undesirable effects of Amikacin 125mg/ml
Amikacin 125mg/ml medicine can cause some unwanted effects, specifically as follows:
Toxicity to the nervous system and ear occurs when using the drug in high doses for a long time. deafness, loss of balance. Nervous system toxicity - neuromuscular congestion: Acute muscle paralysis and dyspnea may occur. Renal toxicity: Increased serum creatinine, blood albumin. Presence of red blood cells, white blood cells in the urine and oliguria. Changes in renal function are usually reversible upon discontinuation of the drug. Other Adverse Reactions: Rarely, include: skin rash, drug-induced fever, headache, paresthesia, muscle tremors, nausea and vomiting, decreased eosinophil count, pain joint pain, anemia and low blood pressure. Ototoxicity, nephrotoxicity.
5. Interactions of Amikacin 125mg/ml
There may be unwanted interactions when using Amikacin 125mg/ml with the following drugs:
Active ingredient Amikacin, specifically Amikacin 125mg/ml can cause vestibular damage. Your doctor will prescribe periodic monitoring of liver function. The therapeutic dose should be reduced in patients with renal impairment.
6. Some notes when using Amikacin 125mg/ml
When using Amikacin 125mg/ml, it should be noted:
Be careful when using Amikacin 125mg/ml: The active ingredient Amikacin in Amikacin 125mg/ml can cause vestibular damage. Use Amikacin 125mg/ml for pregnant or lactating women: Do not use for pregnant and lactating women. Use for driving and operating machinery: Caution should be exercised when using Amikacin 125mg/ml for those who drive and operate machinery. Above is information about uses, dosage and precautions when using Amikacin 125mg/ml. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Amikacin 125mg/ml exactly as directed by your doctor.
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