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If you have a chronic hepatitis B infection, you should receive active antiretroviral therapy and regular monitoring to limit your risk of cirrhosis, liver failure or liver cancer. Ambihep is a commonly used antiviral drug today. So how to use Ambihep?
1. What is Ambihep?
Ambihep belongs to the group of antiparasitic and antiviral drugs indicated for adults with chronic hepatitis B. With the main ingredient is Adefovir dipivoxil 10mg and excipients just enough provided by the manufacturer. The drug is in the form of tablets.2. Indications and contraindications of Ambihep
Indications for Ambihep:
Ambihep is indicated for the treatment of chronic hepatitis B in adults when the test results confirm that the hepatitis B virus is active and/or have chronic elevations of liver enzymes, tissue disease. progressive learning. Contraindications to Ambihep:
Patients with enlarged liver; Fatty stools; Metabolic acidosis; There is a history of allergy to one of the ingredients of the drug.
3. Dosage and how to take Ambihep
3.1. Dosage of Ambihep Chronic hepatitis B with good renal function is 10mg/tablet/day.
Chronic hepatitis B: Take 1 tablet/day. In patients with hepatic impairment, no dose adjustment is required.
Patients with renal failure:
Creatinine clearance from 20-49ml/min: 10mg/48 hours; Creatinine clearance from 10-19ml/min: 10mg/72 hours; Patients on hemodialysis: 10 mg every 7 days after dialysis or after cumulative dialysis for a total of 10 hours. 3.2. How to use Ambihep Drug Ambihep is taken orally, can be taken before, during and after eating. Do not chew, break or crush the medicine into a powder to make it easier to swallow, but take the tablet whole.
4. How to handle overdose, forget dose
Ambihep overdose:
Signs of mild to moderate gastrointestinal disturbances when taking a daily dose 25-50 times higher (250-500mg) than the recommended dose for 14 days. When symptoms of overdose occur, monitor for signs of toxicity and apply supportive treatment if necessary. Ambihep can be eliminated by hemodialysis with a clearance of 104 ml/min. Missed dose of Ambihep:
Absolutely do not take twice the prescribed dose when it is discovered that you have missed a dose. Take the missed dose as soon as you remember it. Skip the missed dose when it is almost time for your next dose. It is advisable to take the medicine at the same time of day to avoid missed doses.
5. Ambihep . side effects
When using Ambihep, patients often experience undesirable effects such as:
Asthenia, headache, abdominal pain, diarrhea, nausea, indigestion, flatulence, increased creatinine and decreased blood phosphate; Digestive: pancreatitis ; Musculoskeletal system and connective tissue: Myopathy, osteoporosis; Renal and urinary: Renal failure, fanconi syndrome, proximal tubule disease; Increased liver enzyme levels and acute exacerbations of hepatitis after discontinuing Ambihep; Lactic acidosis, associated with severe hepatomegaly and steatosis, may occur with the use of nucleoside analogues alone or with antiretrovirals; Close monitoring of adverse events is required when Ambihep is co-administered with drugs that are excreted by the kidney or with drugs known to affect renal function. Inform your doctor about the side effects that occur when taking the drug for full advice.
6. Drug interactions
Ambihep and Tenofovir disoproxil fumarate should not be used concurrently; Patients should be closely monitored when Ambihep is used together with drugs that are excreted or affect renal function; Taking 800mg of Ibuprofen 3 times a day increases the concentration of Ambihep by about 23%.
7. Note and store Ambihep
Note when using Ambihep:
Ambihep can increase liver enzymes high and fast, so it is necessary to monitor liver and kidney function every 3 months if the drug is used for a long time; An acute exacerbation of hepatitis may occur in patients who discontinue hepatitis B therapy during treatment with Ambihep. Therefore, both laboratory and clinical examination should be performed, followed up for at least several months after discontinuation of the drug. Re-treat hepatitis B if necessary; All patients should be checked for creatinine before starting treatment with Ambihep to limit the risk of nephrotoxicity; Monitor patient renal function during Ambihep treatment in patients with a history or risk of renal impairment and dose adjustments may be appropriate; Pregnant and lactating women: It is necessary to weigh the benefits and risks when using the drug; Children: Safety and effectiveness for use in pediatric patients have not been established; Due to effects such as dizziness, drowsiness, visual disturbances that will impair concentration and reflexes, be careful when driving or operating machinery. Ambihep drug storage:
Ambihep should be kept in a cool, dry place, avoiding direct light on the medicine. The above is important information about Amapirid, its use for the right purpose helps the treatment process to be highly effective and minimize side effects. Therefore, consult your doctor/pharmacist before taking Ambihep.
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