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There are many classes of antihypertensive drugs in clinical use and Aldomet 250mg is one of them. Although less common than other drugs, the effectiveness of Aldomet is also significant. So what drug Aldomet and what should patients pay attention to when using?
1. Uses of Aldomet
Aldomet contains the active ingredient Methyldopa 250mg, belongs to the group of drugs that control blood pressure through the mechanism of central sympathomimetic. Aldomet 250mg has the effect of lowering blood pressure by reducing the concentration of several mediators in the patient's blood. This results in a dilating effect on blood vessels, including veins and arteries.
Aldomet 250mg product is mainly used in the treatment of hypertension. In addition, Aldomet may be used for some purposes not listed in this medication guide.
2. Pharmacological characteristics of Aldomet 250mg
2.1. Pharmacodynamics Methyldopa is a central alpha-adrenergic stimulant to decrease peripheral sympathetic tone. It has the effect of reducing sympathetic activity and blocking adrenergic receptors.
2.3. Pharmacokinetics Absorption: Aldomet 250mg is absorbed from the gastrointestinal tract about 50%. Methyldopa begins to lower blood pressure after 4 hours and can last up to 24 hours. Distribution: Aldomet 250mg is weakly bound to plasma proteins and can cross the placenta and breast milk. Metabolism: Aldomet undergoes first-pass metabolism in the liver, so its gastrointestinal bioavailability is low (only about 25%). Elimination: Methyldopa is eliminated by the kidneys slowly, the elimination half-life of Aldomet is about 2 hours.
3. Some warnings regarding Aldomet 250mg
Patients should not use Aldomet 250mg if they have liver disease (especially cirrhosis) or a history of liver problems while taking Methyldopa.
Do not use Aldomet 250mg for cases where MAO inhibitors have been used in the previous 14 days, such as Isocarboxazid, Linezolid, methylene blue, Phenelzine, Rasagiline, Selegiline or Tranylcypromine.
Patients with hypertension should not use Aldomet if there is a history of previous allergy to Methyldopa, and inform the doctor if the history of the following problems:
Liver disease; Kidney disease or if end-stage renal failure requires hemodialysis; Cardiovascular disease, angina pectoris; Heart attack or cerebrovascular accident. Inform your doctor if you are a woman who is pregnant or planning to become pregnant. It is currently unknown whether Aldomet will harm an unborn baby. However, high blood pressure during pregnancy can cause complications such as diabetes or dangerous pre-eclampsia. Therefore, high blood pressure in pregnant women can lead to dangerous effects for both mother and fetus. One issue of particular concern is that the benefits of treating hypertension may outweigh any risks to the fetus.
Aldomet 250mg may not be safe for use by nursing infants while nursing mothers. Women who are breastfeeding should talk to their doctor about any risks associated with Aldomet 250mg.
4. Instructions for using Aldomet 250mg
Patients with high blood pressure should follow all instructions for using Aldomet 250mg or as directed by their doctor. However, the doctor's decision is the most important, in some cases the doctor may change the dose of Aldomet other than the accompanying instructions.
Checking blood pressure during treatment with Aldomet 250mg should take place regularly, in addition to liver function tests.
Keep taking Aldomet 250mg as directed, even if you feel better. High blood pressure often has no specific symptoms, so the use of blood pressure medications like Aldomet can last a lifetime.
Aldomet 250mg has been shown to affect the results of some laboratory tests. Therefore, in case of request, the patient needs to let the treating doctor know that he is using Aldomet.
In case of surgery or blood transfusion, the patient should tell the treating doctor about the use of Aldomet 250mg.
Dosage of Aldomet in children is based on weight. Therefore, a child's dosage requirements may change with weight gain or loss.
Store Aldomet at room temperature, away from high humidity, extreme heat and direct sunlight.
When using Aldomet in excess of the recommended dose, patients may experience some symptoms such as drowsiness, vomiting, slow heart rate or fainting.
During the use of Aldomet 250m, the patient should avoid changing positions too quickly, especially getting up from a sitting or lying position, due to the risk of dizziness.
5. Side effects of Aldomet 250mg
Positive Coombs test, hemolytic anemia and liver dysfunction; transient feeling of calm, headache; Weakness or weakness; Orthostatic hypotension; Increases salt retention in the body and causes edema; Depression; Impotence; Syndrome similar to systemic lupus erythematosus due to immune abnormalities; pseudo-parkinsonian syndrome; Hyperprolactinemia causes gynecomastia in men and abnormal lactation in women.
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