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When the bone marrow is overactive and produces an excessive number of platelets and enters the blood, it will cause a number of dangerous blood-clotting disorders, increasing the risk of unwanted blood clots. . Therefore, the drug Agrylin is indicated in the treatment of thrombocytopenia to help limit this condition.
1. Uses of Agrilin
Before going to learn about the use of Agrylin, we need to know what Agrylin is?
Agrylin drug including the active ingredient Anagrelide 0.5mg is indicated in the treatment of blood disorders related to thrombocythemia, and the main cause is an increase in the number of platelets accompanied by an overactive bone marrow condition. level.
Platelets are a type of cell that is used in the body's blood-clotting process. Therefore, when there are too many platelets in the blood, it can affect the circulation, including the formation of blood clots and cause bleeding disorders. Furthermore, the drug can inhibit the bone marrow's platelet production and decrease the number of platelets in the blood.
2. How to use Agrylin
Agrylin is taken orally and can be taken with or without food. The drug is used in doses from 2 to 4 times a day or can be prescribed by a doctor.
For children or patients with liver abnormalities, the dose can only be taken once a day. The treating doctor will adjust the dose of the drug once a week for this subject and at the same time will consider choosing the appropriate dose of Agrylin to maintain the platelet count in the body at a normal level. The dose of Agrylin indicated in the treatment of thrombocytopenia depends on the individual patient's thrombocytopenia status as well as the response to the drug. And the maximum dose of Agrylin for each oral dose can be 2.5 mg and this dosage should not exceed 10 mg / day.
Patients need to use Agrylin on a regular basis to promote the highest treatment effect and should take the drug at the same time of day. When the platelet count in the body reaches a normal level, the patient should still use Agrylin in the treatment of thrombocytopenia because most patients have a high platelet count but no specific symptoms. However, when using Agrylin, the patient should not stop using the drug without consulting a doctor. Because stopping using Agrylin can cause platelets in the body to rise again. In addition, the doctor can check the patient's blood count regularly to monitor the progress of the disease as well as adjust the dose of the medicine in time.
3. Some side effects when using Agrylin
Agrylin can cause some common unwanted side effects including: headache, diarrhea, weakness or digestive upset with nausea, bloating, or dizziness.
To reduce the risk of dizziness or lightheadedness, the patient should change position slowly. However, in some rare cases, there may be rare side effects such as unusual bleeding or bruising on the body, black stools or vomiting blood, swelling of the ankles or feet, difficulty breathing or rapid breathing. and folding, or kidney-related problems with changes in urine content and color.
Agrylin can very rarely cause serious allergic reactions. However, patients still need to be aware of allergic effects in order to take timely measures.
Agrylin can affect the patient's heart rate by causing QT prolongation. Prolonged QT causes a faster heartbeat and irregularity in the heart rate that can seriously affect the patient with symptoms of severe dizziness, fainting, and medical attention. right away. The risk of QT prolongation is increased if the patient has certain medical conditions. Therefore, before using antiplatelet drugs, you should talk to your doctor if you have conditions such as: heart failure or bradycardia, a family history of cardiovascular disease or sudden cardiac death. . In addition, low blood potassium and magnesium levels are also factors that increase the risk of QT prolongation. Therefore, patients who are using diuretics that can cause potassium loss or electrolyte disturbances such as sweating, diarrhea will appear side effects when using Agrylin.
Agrylin is only used for pregnant women when absolutely necessary and prescribed by a doctor. There is no evidence that Agrylin passes into breast milk and affects a young baby. However, there is a risk of possible side effects for the infant, so mothers should consult with their doctor before deciding to use Agrylin at this stage.
4. Agrylin drug interactions
Drug interactions that can change the way Agrylin works can reduce the pharmacological effects or increase the risk of side effects. Therefore, before using Agrylin, the patient should list all the drugs that have been used before, including prescription drugs, non-prescription drugs, herbs or supplements. Doing this will help the doctor have the right prescription for the patient to avoid unwanted interactions.
Some drugs can interact with Agrylin drugs such as drugs that can cause bleeding or bleeding such as antiplatelet drugs, anticoagulants, sucralfate,... Especially aspirin is the only drug used. when prescribed by a doctor. Aspirin may increase the risk of bleeding when used with Agrylin, especially in patients at high risk of bleeding. However, in the case of patients using low-dose aspirin can prevent blood clots or prevent myocardial infarction and stroke, they should use the drug as prescribed by the doctor.
Patients using Agrylin drug during treatment still need to perform periodic health check-up to be able to order tests and clinical examination with cardiovascular, electrocardiogram, complete blood count, laboratory tests. Test the function of other organs such as liver, kidneys ... These test results help doctors monitor the progress of the disease and can monitor possible side effects during treatment with the drug. Agrilin.
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