This is an automatically translated article.
Agirovastin 20 is a drug belonging to the group of blood lipid disorders, used to treat cases of hypercholesterolemia, high blood fat that causes health deterioration and increases the risk of cardiovascular disease. Understanding the effects, following the correct indications and dosage of Agirovastin 20 will help patients improve treatment effectiveness and prevent unwanted side effects.
1. Uses of the drug Agirovastin 20
Agirovastin 20 has the main ingredient Rosuvastatin 20mg. Rosuvastatin is a selective and competitive inhibitor of hepatic HMG-CoA reductase, which inhibits the conversion of 3-hydroxy-3-methylglutaryl Coenzyme A to mevalonate, a cholesterol precursor, thereby reducing the formation of cholesterol. cholesterol in the blood. In addition, Rosuvastatin also reduces LDL and VLDL, which are also two types of blood lipids, by increasing the number of LDL receptors on the cell surface in the liver, thereby increasing the absorption and catabolism of LDL and inhibiting the synthesis of VLDL in the liver, contributing to increase the efficiency of blood fat reduction.
2. Indications and contraindications of Agirovastin 20
2.1. Indications Agirovastin 20 Drug Agirovastin 20 is used as an adjunct to diet when patients do not respond adequately to non-pharmacological therapies such as exercise, diet.
Agirovastin 20 is indicated for the treatment of:
Patients with primary hypercholesterolemia or mixed dyslipidemia; Patients with homozygous familial hypercholesterolemia; The patient has atherosclerosis. 2.2. Contraindications to the drug Agirovastin 20 Agirovastin 20 should not be used in the following cases:
Patients with a history of allergy to Rosuvastatin or any of its ingredients; Patients with severe renal impairment, as demonstrated by creatinine clearance less than 30 ml/min Patients with liver disease or unexplained persistent elevations of transaminases. Patients with acute or chronic muscle diseases. Patient is taking Cyclosporin.
3. Dosage and how to use Agirovastin 20
How to use :
It is important for patients to follow a low cholesterol diet, increase exercise and lose weight. The drug Agirovastin 20 is used orally. Patients should take Agirovastin 20mg tablets whole, do not chew, break or crush as this can reduce the effectiveness of the drug. Agirovastin 20 can be taken at any time of the day, depending on the patient's schedule. However, because cholesterol synthesis in the liver occurs mainly at night, taking Agirovastin once a day at night before going to bed will increase the effectiveness of the drug. Dosage:
It is recommended to always start using Agirovastin 20 from the lowest effective dose, then the dose can be adjusted according to the needs and response of each patient. The interval between dose increments is not less than 4 weeks, until the desired LDL cholesterol level or maximum dose is reached. During treatment and dose adjustment, it is necessary to monitor the patient for side effects, especially adverse reactions to the muscle system.
For each patient, selection of the starting dose should be individualized, based on the individual patient's cholesterol level, the risk of future cardiovascular events, as well as the risk of adverse events. unexpected.
Adults: starting dose of 5 - 10 mg/day, may increase up to 20 mg/day Elderly: starting dose of 5 mg/day should be used in patients over 70 years of age, no dose adjustment is required in these patients. this multiplier. Patients with mild to moderate renal impairment (creatinine clearance < 60ml/min): starting dose of 5mg/day and contraindicated at dose of 40mg. Asian patients or patients with risk factors for disease in the musculoskeletal system: starting dose of 5 mg/day and contraindicated at 40 mg.
4. Undesirable effects of the drug Agirovastin 20
Patients may experience some unwanted effects while using Agirovastin 20 such as:
Common: diarrhea, constipation, flatulence, abdominal pain, nausea, headache, insomnia, weakness , muscle pain, joint pain. Uncommon: skin rash, myopathy, rhinitis, pharyngitis, cough. Rare: acute myositis, rhabdomyolysis, possibly leading to acute renal failure. Before prescribing a drug, doctors always weigh the benefits and effectiveness of Agirovastin 20 against the risk of side effects. However, in some cases, patients may still experience unwanted effects when using the drug. Therefore, if you experience unusual symptoms during treatment with Agirovastin 20, you should immediately notify your doctor or go to the nearest medical facility for appropriate treatment.
5. Interactions of Agirovastin 20
Agirovastin 20 may interact if used concurrently with the following drugs and substances:
Fibrate-lowering agents such as Gemfibrozil: Increased risk of muscle damage. Atazanavir, Atazanavir + Ritonavir, Lopinavir + Ritonavir: increased risk of muscle damage, the most dangerous is rhabdomyolysis, nephrotic syndrome, kidney failure and possibly death. Cyclosporin: Increased blood concentration of Rosuvastatin. Warfarin: Increases anticoagulant effect, increases the risk of bleeding. Antacids: Reduces plasma concentrations of Agirovastin 20.
6. Be careful when using drugs
During the use of Agirovastin 20, patients should note:
Must exclude hypercholesterolemia due to other diseases such as hypothyroidism, uncontrolled diabetes, nephrotic syndrome, obstructive liver disease, blood protein disorder, taking some other drugs, alcoholism. It is necessary to measure the levels of total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides before and during treatment. Liver function should be checked before starting treatment with Agirovastin 20 and should be rechecked during treatment. It is necessary to test CK in the following cases: Hypothyroidism, impaired renal function, personal or family history of genetic disorders of the muscular system, history of liver disease or heavy alcohol consumption, elderly patients. > 70 years) with risk factors for rhabdomyolysis. During the course of treatment, if the patient has symptoms of muscle pain, stiffness, or weakness, they must immediately notify the doctor for appropriate treatment. When there are manifestations of acute and severe myopathy or there is a risk of acute renal failure due to rhabdomyolysis in cases such as hypotension, severe acute infection, major surgery and trauma, metabolic and endocrine disorders, Electrolyte disturbances or uncontrolled convulsions requiring immediate interruption or discontinuation of the drug. No information is available on the effect of Agirovastin 20 on the ability to drive and use machines. For women of childbearing age, Agirovastin 20 should be used only after pregnancy has been definitively ruled out and in the event of very high blood cholesterol that has failed other therapeutic agents.
7. Management when forgetting or overdosing Agirovastin 20
Missed dose:
It is important for the patient to take the correct dose as prescribed by the doctor. In case the patient has just forgotten Agirovastin 20 compared to the prescribed in the prescription, the patient can quickly take the supplement as soon as he remembers. If it is time for the next dose, skip the missed dose and take the next dose as scheduled. Do not change the dose without consulting your doctor. Drug overdose:
Currently, there is no official information as well as clinical reports on symptoms occurring when using Agirovastin 20 drug overdose. When using Agirovastin 20 drug overdose, patients need to stop the drug immediately and Notify the treating doctor or go to a medical facility for timely treatment. Patients with an overdose of Agirovastin 20 should be treated symptomatically and supportive measures taken. Monitoring of liver function, renal function, and CK levels should be performed in patients with unusual symptoms when taking high doses of the drug. Above is all information about Agirovastin 20 drug uses, dosage and important notes when using. Carefully reading the instructions for use, understanding the uses, strictly following the instructions and instructions of the doctor will help patients improve the effectiveness of treatment and prevent unwanted effects.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
