This is an automatically translated article.
The drug Agipiro has Piroxicam as the main ingredient, which is often used in the relief of osteoarthritis pain, edema after surgery,... Let's learn more about Agipiro through the article below.1. What is Agipiro?
Agipiro medicine is manufactured by Agimexpharm Pharmaceutical Joint Stock Company, Vietnam. Agipiro is a prescription medicine, classified in the group of analgesics, antipyretics, non-steroidal anti-inflammatory drugs, drugs for the treatment of Gout and osteoarthritis. Agipiro contains Piroxicam as the active ingredient.
Dosage form: Tablets, each containing Piroxicam beta cyclodextrin equivalent to Piroxicam 20mg and other excipients of the manufacturer.
Packing form: Blister of 10 tablets, each box includes 2 blisters and manufacturer's instruction sheet.
2. What does Agipiro do?
Pharmacodynamics: Piroxicam belongs to the group of non-steroidal anti-inflammatory drugs with antipyretic and analgesic effects. In addition, Piroxicam also has anti-edema, erythema, tissue proliferation, fever and pain effects in laboratory animals. Piroxicam is effective against all causes of inflammation, inhibits neutrophil aggregation, inhibits the migration of leukocytes to the inflammatory area. At the same time, Piroxicam has the ability to inhibit enzymes released by lysosomes from stimulated leukocytes, inhibit superoxide anion production, and reduce systemic rheumatoid factor production.Pharmacokinetics:
Absorption: Piroxicam is well absorbed after oral or rectal administration. The rate of absorption is slightly decreased in the presence of food but does not affect the extent of absorption when administered orally. Distribution: High plasma protein binding rate is about 99%. Metabolism: Piroxicam is extensively metabolised by hydroxylation of the pyridyl nucleus of the side branch, followed by conjugation with glucuronic acid. Elimination: Piroxicam is eliminated in the urine, with a plasma half-life of about 50 hours in men.
3. Indications and contraindications of the drug Agipiro
Drug Agipiro is often indicated in the treatment of anti-inflammatory, pain relief in osteoarthritis, rheumatoid arthritis, Gout, ankylosing spondylitis, tendonitis, bursitis, back pain, neuritis, painful swelling, edema after surgery or after trauma.
Contraindications: Absolutely do not use Agipiro in the following cases:
Hypersensitivity to any ingredient of the drug Agipiro. Peptic ulcer disease progression. Gastrointestinal bleeding. Severe gastritis. Liver dysfunction. Renal dysfunction. Pregnant. Breastfeeding mothers.
4. Dosage and how to use Agipiro
Agipiro is a prescription drug, so you must follow your doctor's instructions on the course of medication, do not arbitrarily change the dose or route to avoid adverse health effects. Also, do not share Agipiro with other people or give it to others when they have the same symptoms as you.Dosage:
Adults: Start with a dose of 40mg/day x 2-5 days, then use a maintenance dose of 20mg/day. For severe cases, the dose will be adjusted depending on the medical condition and response of the patient. Children: There is insufficient evidence for the safety of Agipiro in children. Administration: Agipiro is prepared in the form of tablets and taken orally. Swallow the tablet whole with a sufficient amount of water, do not chew or break the tablet.
What to do if you miss a dose of Agipiro ?
When you miss a dose, take another dose as soon as you remember. If it is almost time for your next dose, skip the missed dose, do not increase the dose, or take a double dose to make up for the missed dose. What to do in case of an overdose of Agipiro?
When an overdose is suspected, it is necessary to quickly bring the patient to the nearest medical facility for timely emergency treatment. Bring all the drugs the patient has used before, including oral, injectable, topical, spray, ... to facilitate diagnosis.
5. Undesirable effects
Agipiro is generally well tolerated, the most common undesirable effects are gastrointestinal symptoms, but in most cases do not affect the course of treatment.Similar to other non-steroidal anti-inflammatory drugs, Agipiro may temporarily increase liver enzymes, reduce platelet aggregation and bleeding time.
Hypersensitivity reactions on the skin occur in very small proportions.
This is not a complete list of undesirable effects that occur when using Agipiro medicine, patients may experience other symptoms that have not been reported or studied. Therefore, to be on the safe side, contact your doctor immediately when any abnormal signs appear during the course of Agipiro.
6. Drug interactions
When treating with many drugs, there may be interactions between drugs or interactions between drugs and foods and drinks, especially alcohol and stimulants. This can lead to changes in bioavailability, effects, and even increased unwanted effects of the drug. In addition, some medical conditions such as diabetes, immunodeficiency, ... can also affect the effectiveness of the drug. Therefore, to be safe, you need to list and tell your doctor or about the medications you are taking (including prescription and non-prescription drugs, vitamins and minerals, herbal products, etc.). ..), existing diseases,... Some drugs may interact with Agipiro such as: when treated with many drugs, interactions between drugs or interactions between drugs and food may occur. , drinks, especially alcohol, stimulants. This can lead to changes in bioavailability, effects, and even increased unwanted effects of the drug. In addition, some medical conditions such as diabetes, immunodeficiency, ... can also affect the effectiveness of the drug. Therefore, to be safe, you need to list and tell your doctor or about the medications you are taking (including prescription and non-prescription drugs, vitamins and minerals, herbal products, etc.). ..), existing diseases,... Some drugs can interact with Agipiro such as:
Coumarins: When using Coumarins and Agipiro at the same time, it may increase the anticoagulant effect of Coumarins. Probenecid: The combination of Probenecid and Agipiro increases the elimination rate of Agipiro. Agipiro has no pharmacodynamic interactions with Antacids, Cimetidine and hypoglycemic agents, however, the effectiveness of anticoagulants and hypoglycemic agents should be monitored when initiating Agipiro therapy.
7. Some notes when using Agipiro
Before being prescribed Agipiro, tell your doctor if you have the following conditions:
Exacerbation of peptic ulcer. Upper gastrointestinal disease. Heart failure . Hypertension. Cirrhosis. Nephrotic syndrome and kidney diseases. Severe liver and kidney disease. Under 15 years old. Pregnant. Breastfeeding. Hypersensitivity to Aspirin and NSAIDs.
8. Preservation of drugs
Store Agipiro in the original manufacturer's packaging, in a cool, clean place away from direct sunlight, at a temperature below 25 degrees Celsius. Keep Agipiro out of reach of children and objects. rearing, avoiding them not knowing how to chew can cause serious unwanted effects. Agipiro drugs have a shelf life of 36 months, do not use drugs that have expired or show signs of change in color, properties, taste, no labels. Do not throw Agipiro down the toilet or plumbing unless told to do so.
