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Agdicerin is a product of Agimexpharm Pharmaceutical Joint Stock Company with the main ingredient being Diacerein 50mg. This medication is used to treat osteoarthritis and reduce symptoms of pain and swelling associated with osteoarthritis. So what is the use of Agdicerin, dosage, how to use it?
1. Uses of the drug Agdicerin
Main ingredients in each Agdicerin tablet include:
Diacerein: 50mg Excipients: just enough 1 tablet. Diacerein is an anti-osteoarthritis agent commonly indicated in osteoarthritis, degenerative joint diseases and related diseases. Drugs that do not inhibit prostaglandin synthesis should be well tolerated in the stomach. Diacerein has the ability to affect both anabolism and catabolism of chondrocytes and reduce proinflammatory factors. This result is possible because Diacerein and its active metabolite, Rhein, inhibit the production and activity of the cytokine IL-1b. In the synovial membrane, synovial fluid, and articular cartilage in both the superficial and deep layers, the cytokine IL-1b is a proinflammatory and pro-catabolic factor.
Clinical studies comparing treatment with Diacerein and placebo showed a significant difference in pain relief and improved joint function in patients taking the drug. The beneficial effects of Diacerein treatment persisted for at least 2 months after treatment was discontinued. A 3-year, multicenter randomized double-blind study in 507 patients with osteoarthritis of the hip also found that diacerein slowed cartilage degeneration.
2. Indications of the drug Agdicerin
Agdicerin is indicated for the symptomatic treatment of patients with slowly progressing osteoarthritis of the knee or hip.
Agdicerin is not recommended in patients with rapidly progressive osteoarthritis because these patients respond poorly to Diacerein.
3. Contraindications of Agdicerin
The following subjects are not indicated to use Agdicerin:
People with a history of or are having liver disease People with a history of severe dehydration, severe hypokalemia, severe diarrhea requiring hospitalization People with a history of over Hypersensitivity to Diacerein or any of its ingredients
4. Dosage and how to use Agdicerin
Usage: Agdicerin is used orally. Patients should take the entire Agdicerin 50mg tablet, do not chew, break, or crush it because it can reduce the effectiveness of the drug. The drug is usually taken with meals to increase absorption.
Dosage
Recommended starting dose: 50 mg/time/day for the first 2-4 weeks, usually in the evening. After that, the dose can be increased to: 50 mg / time x 2 times / day, taken in the morning and evening. Note:
Because Agdicerin may have a slow onset of action in some patients, doctors should encourage patients not to discontinue treatment before 2-4 weeks, until the drug's effectiveness is evident.
Agdicerin is safe when used with anti-inflammatory drugs of the NSAID group, so it can be prescribed to patients in the first 2-4 weeks to increase the effectiveness of pain relief.
Agdicerin should not be used in patients 65 years of age or older, especially those with a history of diarrhea because the drug can cause loose or diarrhea leading to dehydration.
5. Side effects of the drug Agdicerin
Although Agdicerin is the indicated drug, some patients still experience unwanted effects during treatment. Agdicerin drugs mainly cause side effects on the gastrointestinal tract and skin or subcutaneous tissue such as:
Very common: diarrhea, abdominal pain Common: flatulence, increased intestinal motility Hepatobiliary disorders: increased liver enzymes in the blood Skin and subcutaneous tissue disorders: pruritus, eczema, skin rash These effects subside when the patient stops taking the drug. However, in some cases, patients have loose stools, severe diarrhea that leads to electrolyte disturbances or dehydration.
Some patients may experience dark urine, this is due to the compound in the medicine. The patient should be explained that this phenomenon is not clinically significant.
Patients experiencing side effects during the use of Agdicerin should immediately notify their doctor for appropriate treatment.
6. How to handle when forgetting medication, overdose Agdicerin
Forgotten dose:
If the patient has just forgotten to take Agdicerin after 1-2 hours, it is necessary to quickly take the supplement as soon as he remembers. However, if it is time for the next dose, take the next dose exactly as prescribed, do not double the dose of Agdicerin on your own. Drug overdose:
Patients who overdose when using Agdicerin often cause diarrhea, if too high a dose is used, it can lead to prolonged diarrhea causing dehydration. It is necessary to treat symptoms, rehydrate and electrolytes and closely monitor the patient for timely treatment.
7. Note when using Agdicerin drug
Caution should be exercised when using Agdicerin in patients receiving diuretics because of the increased risk of dehydration and hypokalemia. In patients with a history of intestinal disorders, especially irritable colon, the benefits and risks should be weighed when considering the use of Agdicerin. Patients who take Agdicerin regularly can cause diarrhea leading to dehydration and hypokalemia. If you experience diarrhea while using Agdicerin, the patient should stop the drug and notify the treating doctor for instructions on how to handle it. Caution should be exercised in patients receiving cardiac glycosides, because of the risk of hypokalemia. Avoid using Agdicerin concurrently with laxatives. Before administering Agdicerin, the patient should be asked about the history of liver disease. During treatment, it is necessary to closely monitor for clinical and laboratory signs of liver damage. Discontinue Agdicerin if elevated liver enzymes are detected or symptoms of acute liver injury are suspected. Agdicerin is not indicated for children under 15 years of age because safety has not been established. The safety of Agdicerin in pregnant women has not been studied. Therefore, it should not be used in this population. Lactating women: Diacerein may be excreted in breast milk, so it is recommended that mothers taking Agdicerin are not used. Do not breastfeed. Store Agdicerin in a cool place, away from light and at a temperature below 30oC. Above is all information about Agdicerin's uses, dosage and important notes when using. Agdicerin is a prescription drug, and patients should only use it according to their doctor's instructions to make the treatment process effective and reduce side effects.
