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Vorifend forte drug has the main ingredient is glucosamine, is prepared in the form of 500mg film-coated tablets. The drug is indicated for the symptomatic treatment of mild to moderate knee osteoarthritis. To ensure effective use, users should refer to the information in the following article.
1. What is Vorifend Forte?
Vorifend forte has the main ingredient is glucosamine, is prepared in the form of 500mg film-coated tablets. The drug is indicated for the symptomatic treatment of mild to moderate knee osteoarthritis.
Mechanism of action of the drug Vorifend Forte 500 mg
In vitro studies on the effects of glucosamine on chondrocytes, the cells responsible for cartilage synthesis, including inhibition of oxidative damage, promotion of phenotypes chondrogenic, modulated proliferation and matrix synthesis, inhibited chondrocyte differentiation, inhibited hyaluronan synthesis and GAG sulphation, increased expression of aggrecan genes and type II collagen, and inhibited mitogen-activated protein kinase phosphorylation. Glucosamine has been shown to suppress synovial cell activation by IL-1beta, increase synovial GAG synthesis, increase hyaluronic acid production in the synovial sample, and downregulate matrix metalloproteases and chemokines in fibroblasts synovial fiber.
Glucosamine can increase the lubricating ability, increase the viscosity of synovial fluid by increasing the production of synovial mucus. Therefore, glucosamine not only reduces the symptoms of osteoarthritis (such as difficulty in movement, pain) but also prevents the progression of the disease, as well as prevents the process of joint degeneration.
Absorption of the drug Vorifend Forte 500 mg Vorifend forte is absorbed through the gastrointestinal tract up to 90 - 98%, easily moves into the articular cartilage cells, helping to stimulate the synthesis of glycosaminoglycans (the key factor). cartilage).
Metabolism of Vorifend Forte 500 mg The bioavailability of glucosamine is approximately 26% after first-pass hepatic metabolism. Animal studies have shown that glucosamine rapidly diffuses into tissues and binds to serum proteins and other biological structures of the body, liver, kidney, and joint cartilage, where glucosamine concentrations are highest.
In addition to hepatic metabolism, glucosamine can be converted to CO2 and excreted through the respiratory tract. Part of glucosamine that is not metabolized by the liver or not conjugated with plasma proteins is eliminated mainly in the urine; Glucosamine is found in the feces as the unabsorbed fraction.
Excretion of the drug Vorifend Forte 500 mg According to radiolabelled studies in animals, the elimination half-life of the drug is about 28 hours.
2. What are the uses of Vorifend Forte 500 mg?
2.1. Contraindications of the drug Vorifend Forte 500 mg Women who are pregnant or breast-feeding Children under 18 years of age have not yet had accurate studies for the use of this drug in this group of people. Be careful when using the drug Vorifend forte 500 mg
Vorifend forte 500 mg is quite benign, so it can be treated for a long time. Besides, the drug does not cause gastrointestinal disorders. Patients should repeat treatment every 6 months or shorter, depending on each patient's condition.
The effect of the drug can take effect after about 1 week, so if the patient has a lot of pain, they can use more pain relievers, anti-inflammatory drugs in the first few days.
Glucosamine is generally considered safe. However, caution is still needed when given to people with poorly controlled diabetes or liver disease. Use with caution in people with shellfish allergies or asthma.
2.2. Undesirable side effects of Vorifend forte 500 mg Common side effects may include: nausea, vomiting, diarrhea, constipation or possible heartburn. Call your doctor or go to the nearest medical facility if you have any of the following signs of an allergic reaction while taking glucosamine: hives; shortness of breath; swelling of the face, lips, tongue, or throat.
2.3. Drug interactions With anticoagulants: Vorifend forte 500 mg may increase the prothrombin-lowering effect of anticoagulants. Glucosamine is a chemical component of heparin and has been shown in vitro and in animals to prolong prothrombin time. However, adverse effects on coagulation and bleeding complications have not been reported in clinical studies when glucosamine was used at doses up to 1.5 and 1.2 g/day, respectively.
Using Vorifend forte with NSAIDs can cause stomach bleeding, the doctor may prescribe the patient to reduce the dose of NSAID. Glucosamine may alter the dose required for insulin and hypoglycemic agents. 2.4. Precautions while using Vorifend forte 500 mg If you choose to use Vorifend forte 500 mg, use it as directed on the package or as directed by your doctor or pharmacist. Do not use more than the recommended dose printed on the label. Do not take medicines with the same glucosamine active ingredient but different brand names at the same time without your doctor's advice. Using different brand-name drugs at the same time increases the risk of glucosamine overdose. The glucosamine in Vorifend forte 500 mg may cause abnormal results in blood glucose (sugar) tests. Do not use this product without your doctor's advice if you have diabetes. If you need surgery, tell the surgeon in advance that you are using Vorifend forte 500 mg. Your doctor may ask you to stop taking the medicine for a short time. It may take up to 8 weeks before your symptoms improve. For best results, continue using Vorifend forte 500 mg as directed. Call your doctor if your symptoms do not improve or if they get worse while using Vorifend forte 500 mg.
3. How to use Vorifend Forte 500 mg effectively?
3.1. Dosage of the drug Vorifend Forte 500 mg Vorifend forte is administered orally. Accordingly, the patient should not bite, chew or crush the tablet before taking it. Take the medicine with cooled boiled water to avoid infections. 3.2. Dosage of the drug Vorifend Forte 500 mg Adults over 18 years old: Take from 1250 mg to 1500 mg of glucosamine/day (corresponding to about 1592 - 1910 mg of glucosamine sulfate), divided into 3 times. Glucosamine sulfate can be used alone or in combination with other drugs such as chondroitin 1200 mg/day. The duration of drug use depends on the individual, at least continuously for 2-3 months to ensure the effectiveness of treatment. Note: The above dosage is for reference only. The specific dose depends on the condition and the progression of the disease. To get the right dose, you need to consult your doctor or healthcare professional.
Vorifend forte drug has the main ingredient is glucosamine, is prepared in the form of 500mg film-coated tablets. The drug is indicated for the symptomatic treatment of mild to moderate knee osteoarthritis. To ensure effective use, users need to strictly follow the instructions of the consulting doctor.
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