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Celebrex is a non-steroidal anti-inflammatory drug (NSAID). Selective inhibitor of the enzyme cyclooxygenase-2 (COX-2) with the active ingredient celecoxib.1. Basic information of the drug Celebrex
Celebrex drug is originated from Pfizer Pharmaceuticals LLC - USA. The drug is prepared in the form of hard capsules with packaging of 3 blisters, each blister of 10 tablets. The main ingredients of the drug each tablet contains: Celecoxib 200 mg and excipients just enough.
2. Effects of the drug Celecoxib
Celebrex is an active ingredient in the group of non-steroidal anti-inflammatory drugs (NSAIDs).Unlike some other substances, Celecoxib has a selective inhibitory effect on the enzyme Cyclooxygenase 2 (COX-2). This is an enzyme that responds to an inflammatory agent. This leads to the inhibition of the synthesis of Prostaglandin E2, which is the main cause of pain, swelling, inflammation, and edema.
Because it does not affect the COX-1 enzyme, all physiological processes related to this enzyme on the intestines, stomach, and platelets are not affected. That is, Celecoxib does not cause as many side effects as both COX-1 inhibitors.
On clinical studies of therapeutic efficacy in pain, ankylosing spondylitis, rheumatoid arthritis, osteoarthritis...
3. Indications of the drug Celecoxib
Celebrex 200mg drug is used in the following cases:
Degenerative conditions and rheumatoid arthritis in adults. Persistent pain in cancer and other chronic diseases. Juvenile idiopathic arthritis in children 2 years of age and older with a weight of at least 10 kg. The patient has ankylosing spondylitis. Acute pain in trauma and surgery. Primary dysmenorrhea in women.
4. How to use Celebrex
You should take the whole pill with a full glass of water. In case the patient has difficulty swallowing, the tablet can be crushed with a smoothie to drink. The medicine can be taken before, during or after meals. Because food does not affect the absorption of the drug.
Do not use the medicine when it is moldy and the expiry date indicated on the label.
5. Dosage of Celebrex
Absolutely do not self-medicate without a doctor's prescription. The principle of dosing is to use the lowest dose that responds to the reduction of cardiovascular risk. Comply with all instructions in the application, you can refer to the dosage below (dose applicable for adults):
Rheumatoid arthritis: 1 tablet / time, 2 times / day. Ankylosing spondylitis: 1 tablet/time/day, some patients respond well to a dose of 2 tablets/day. Osteoarthritis: 1 tablet/time/day.
Use to relieve acute pain: The first day take 2 tablets / time, the next days 1 tablet / time. Treatment of primary dysmenorrhea: The usual dose is 2 tablets / time, especially the first day of the cycle can be used 3 tablets / time. Note to children with idiopathic arthritis:
Children from 2-12 years old: Only small amounts of preparations such as 50 mg and 100 mg capsules should be used to easily divide the dose during the day. Children from 12-17 years old: Suitable for using Celebrex 200mg, 1 tablet per day.
6. How to handle missed dose and overdose
When you miss a dose, take a replacement dose and complete the number of doses. Never take a double dose.
According to clinical studies, overdose is rare. With a total dose of 1200mg/day in healthy people, no side effects were observed. However, in some cases, if the patient shows signs of acute poisoning, they should be taken to the nearest hospital to take measures to remove the drug from the body.
7. Contraindications of the drug
Celebrex 200mg drug is not used for some of the following subjects:
People who are hypersensitive to any of the ingredients of the drug. Patients with asthma, urticaria, allergic reactions Aspirin and active NSAID group. People with a history of allergy to Sulfamid. Patients with severe liver failure. Caution:
People with cardiovascular diseases. Because Celecoxib increases the risk of thrombosis, stroke, hypertension, myocardial infarction, cardiac edema. People with kidney failure due to NSAIDs are nephrotoxic. People with dehydration, electrolyte disorders. Patients with a history of peptic ulcer disease. Especially in the elderly. People using oral anticoagulants.
8. Undesirable effects
When taking Celebrex, there will be some side effects in some patients with different frequencies:
Common side effects: Sinusitis, insomnia, dizziness, cough, vomiting, abdominal pain, diarrhea , dyspepsia, upper respiratory tract infections. Uncommon side effects: Pharyngitis, rhinitis, hypersensitivity, somnolence, blurred vision, tinnitus, anxiety, restlessness, increased muscle tone, gastric ulcer. Rare side effects: Duodenal ulcer, esophagitis, congestive heart failure, anaphylaxis, thrombocytopenia, anemia, confusional state.
9. Drug interactions
Concomitant use of Celecoxib with some of the following substances causes interactions:
Warfarin, Heparin: Increases the risk of bleeding. Antihypertensives, including ACE inhibitors, diuretics: Reduces antihypertensive effect. Dextromethorphan, Metoprolol: Celecoxib will increase plasma concentrations of these substances. Lithium: Increases blood levels and increases toxicity of lithium. NSAID: Increases unwanted effects. Reduces the effectiveness of oral contraceptives. Hopefully with the sharing of important information about the drug Celebrex, it will help the use process to achieve better results.
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