Uses of Actifif Nic

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Actifif Nic drug is made in the form of tablets, with the main ingredient in each tablet is 2.5mg Triprolidine hydrochloride and 10mg Phenylephrin hydrochloride. So what is Actifif Nic drug, how does it work?

1. What is Actifif Nic?


Triprolidine hydrochloride in Actifif Nic is a derivative of propylamine, a 1st generation antihistamine. Triprolidine has an inhibitory effect on histamine by inhibiting H1 receptors, it also has mild drowsiness and antimuscarinic effects. . Phenylephrine hydrochloride in Actifif Nic is an alpha 1 sympathomimetic agent, which acts directly on alpha 1 adrenaline receptors causing vasoconstriction and an increase in blood pressure. Phenylephrine hydrochloride's blood pressure-raising effect is weaker than that of norepinephrine but lasts longer.
At therapeutic doses, Phenylephrine has practically no stimulant effect on the heart's beta adrenergic receptors, but at larger doses it does stimulate this receptor. Phenylephrine does not stimulate bronchial or peripheral beta adrenergic receptors. At therapeutic doses, Phenylephrine has no effect on the central nervous system.
Actifif Nic is indicated in the treatment of symptoms of the following diseases:
Acute allergic rhinitis; Vasomotor rhinitis ; The common cold. Actifif Nic is contraindicated in the following cases:
Patients with a history of intolerance to Actifif Nic or any of its components; Severe cardiovascular disease; Heart attack; Coronary artery disease ; Severe hypertension; Atrioventricular block; Severe hardening of the arteries; Ventricular tachycardia ; Severe hyperthyroidism or angle-closure glaucoma; Acute asthma attack; Are being treated with a monoamine oxidase inhibitor or have stopped taking them for less than 2 weeks. Actifif Nic should be used with caution in the following cases:
Severe liver failure because of the risk of drowsiness; People with renal failure need to reduce the dose; Prostate enlargement, urinary retention; Closed angle glaucoma; pyloric stenosis ; Seizures, sometimes convulsions; Avoid drinking alcohol while taking Actifif Nic because of the risk of drowsiness. Children and adults over 60 years old are more likely to experience side effects from Actifif Nic; Hyperthyroidism; slow heart rate; Partial heart block; Heart disease; Type 1 diabetes ; Actifif Nic drug causes drowsiness, so do not use for driving or operating machinery; Do not use Actifif Nic for pregnant and lactating women.

2. Dosage and how to take Actifif Nic


Actifif Nic drug is used orally, the dose of the drug should be according to the doctor's prescription. Reference dosage is as follows:
Adults and children over 12 years old: Use dose 1-2 tablets/time x 3 times/day. Children 6-12 years old: Use 1 tablet/time x 3 times/day. Children under 6 years: As directed by a doctor. Symptoms of Actifif Nic overdose related to Triprolidine hydrochloride: Usually symptoms of central nervous system depression or irritation, low blood pressure, shortness of breath, loss of consciousness, convulsions, very dry mouth, nose, throat. In this case, it is necessary to stop taking the drug, if possible, induce vomiting, and give the patient activated charcoal to drink.
Symptoms of drug overdose Actifif Nic related to Phenylephrine hydrochloride: Increased blood pressure, headache, palpitations, convulsions, cerebral hemorrhage, extrasystoles, bradycardia often occur early, paresthesia. Management of this case is as follows:
Reversible hypertension by using an Alpha-adrenergic blocker such as Phentolamine 5-10 mg, intravenously; If necessary, the above dose can be repeated. Hemodialysis is not usually helpful in this case. Attention should be paid to symptomatic treatment and general support for the patient.

3. Actifif Nic . side effects


Side effects of Actifif Nic drug related to Triprolidine hydrochloride:
Common side effects include:
Drowsiness; Headache; Tired; Poor coordination. Less common side effects include:
Blurred vision; Urinary retention, less urination; Dry mouth, nose, throat; Chest tightness. Rare side effects include:
Agranulocytosis; Decrease in neutrophils; Thrombocytopenia; Hemolytic anemia ; Orthostatic hypotension; Tinnitus ; Allergic reactions and cross-immunity with other drugs; Mania, especially in young children, causes insomnia, irritability, tachycardia, tremors, convulsions; Presence of seizures in patients with focal lesions on the cerebral cortex. The side effects of Actifif Nic are related to Phenylephrine hydrochloride:
Common side effects include:
Nervous excitement; Jitter; Concerned; Difficulty sleeping; Weak and tired people; Dizzy; Chest pain ; Trembling; Paresthesia of extremities; Hypertension; Pale, white skin; Feeling cold skin, hair standing up. Uncommon side effects include:
Hypertension, accompanied by pulmonary edema; Arrhythmia ; slow heart rate; Peripheral and visceral vasoconstriction, reducing perfusion to these organs; Respiratory failure ; euphoria; Illusion; Paranoia . Rare side effects include:
Focal myocarditis ; Hemorrhage under the pericardium. If you experience any side effects of Actifif Nic, tell your doctor or go to a medical facility to get timely support from medical staff.

4. Actifif Nic interactions with other drugs


Interactions related to the Triprolidin hydrochloride component of Actifif Nic:
The combination of Actifif Nic with central nervous system depressants such as Barbituric, sleeping pills, Opioids, sedatives and neuroleptics, alcohol because Triprolidin causes increase the effect of these drugs. Monoamine oxidase (MAO) inhibitors may potentiate the antimuscarinic effect of triprolidin in Actifif Nic and other antihistamines. Triprolidine in Actifif Nic has a synergistic effect with antimuscarinic drugs such as atropin, tricyclic antidepressants and similar compounds. Using Actifif Nic with 5-HTP, GABA, banyan leaf, melatonin, valerian will increase the sleep-inducing effect of Triprolidine. Drug interactions related to the Phenylephrine hydrochloride component in Actifif Nic:
Using Actifif Nic together with alpha adrenergic blockers will reduce the blood pressure-raising effect of Phenylephrine hydrochloride. Using Actifif Nic with phenothiazines will reduce the effect and duration of the increase in blood pressure of Phenylephrine. The use of Actifif Nic together with propanolol and beta-adrenergic blocking agents will inhibit the cardiac stimulant effects of Phenylephrine. When using Actifif Nic with the birth control drug (Oxytocin) the effect of increasing blood pressure will increase. Actifif Nic should not be combined with sympathomimetic drugs because tachycardia and arrhythmias may occur. Co-administration of Actifif Nic with halogenated hydrocarbon anesthetics (such as Cyclopropan) increases cardiac excitability and may cause arrhythmias. Concomitant use of Actifif Nic with Monoaminoxydase (MAO) increases cardiac stimulant effects and increases blood pressure due to decreased metabolism of Phenylephrin. Using Actifif Nic with tricyclic antidepressants (such as Imipramine) or Guanethidine will increase the blood pressure-raising effect of Phenylephrine. Using Actifif Nic together with ergot alkaloids in the form of injection increases the antihypertensive effect of Phenylephrin very strongly. Using the drug Actifif Nic together with Digitalis increases the degree of myocardial sensitivity. Using Actifif Nic together with furosemide or other diuretics reduces the antihypertensive effect of Phenylephrine. Do not use Actifif Nic in combination with Bromocriptin because of vasoconstriction and hypertension. Above is information about uses, dosage and precautions when using Actifif Nic. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Actifif Nic exactly as directed by your doctor.

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