This is an automatically translated article.
The article was consulted with Pharmacist Cao Thanh Tu - Faculty of Pharmacy - Vinmec Times City International Hospital.The content of augmentin on the market today is quite diverse, including augmentin 250mg, 500mg, 625mg, 1g,... depending on age, adult or child, weight, drug response and severity of infection bacteria.
1. Augmentin drug forms
Active ingredients:
Augmentin antibiotic is a combination of two active ingredients: Amoxicillin (as amoxicillin trihydrate) Clavulanic acid (as potassium clavulanate) Excipients:
Augmentin tablet: Types of excipients involved tablet production process, including disintegrating excipients, gelling agents, anti-adhesive agents, coloring agents...; Augmentin in sachets: Excipients involved in the production of powder for suspension, including disintegrating excipients, anti-stick agents, filler excipients, flavoring...; Dosage form:
Currently, Augmentin on the market has two most popular dosage forms: film-coated tablets and powder for oral suspension.
2. What are the strengths of Augmentin?
Augmentin strength is usually expressed as both amoxicillin/clavulanate (eg Augmentin 500mg/125mg), except when it is necessary to specify the dose of each ingredient separately:
Augmentin 250mg: Each Augmentin units containing 250mg of amoxicillin and 62.5mg of clavulanic acid, or augmentin 250mg/31.25mg, with a clavulanic acid content of 31.25mg. Augmentin 625mg (or Augmentin 500mg): Each Augmentin unit contains 500mg of amoxicillin and 125mg of clavulanic acid (or 62.5mg). Augmentin 1g: Each Augmentin unit contains 875mg of amoxicillin and 125mg of clavulanic acid.
3. Dosage of Augmentin with different subjects
Dosage of Augmentin depends on age, weight, kidney function, patient's response to medication and severity of infection:Augmentin dose for adults:
| Nhiễm khuẩn từ nhẹ tới vừa | Nhiễm khuẩn nặng (như nhiễm khuẩn đường tiết niệu tái phát và mạn tính, nhiễm khuẩn đường hô hấp dưới) |
| 1000/125 mg x 2 lần/ngày. | 1000/125 mg x 3 lần/ngày. |
Augmentin dose for children under 12 years old:
Recommended dose for children under 12 years old is calculated by weight: 40/5 mg/kg/day to 80/10 mg/kg/day (do not use more than 3,000 mg amoxicillin/375mg clavulanic acid per day), divided into 3 times, depending on the severity of the infection and the doctor's prescription.
The length of treatment depends on the patient's response and the type of infection. Some serious infections (such as osteomyelitis) require longer treatment. There is currently no recommended dose for premature infants.
Augmentin dose for the elderly:
No need to adjust the dose, use the same dose of Augmentin as adults. If there are signs of renal impairment, the dose should be adjusted according to the subject of renal impairment.
Augmentin dose in case of renal failure:
Augmentin should only be used for patients with glomerular filtration rate >30 ml/min.
|
Suy thận nhẹ (CrCl > 30 ml/phút) |
Suy thận trung bình (CrCl 10 - 30 ml/phút) |
Suy thận nặng (CrCl < 10 ml/phút) |
| Không cần thay đổi liều dùng (nghĩa là 1 viên Augmentin 625mg x 2 lần/ngày hoặc 1 viên 1 g x 2 lần/ngày). | 1 viên Augmentin 625mg x 2 lần/ngày. Không nên dùng viên Augmentin 1g. | Dùng không quá 625 mg Augmentin mỗi 24 giờ. |
Augmentin dose for people on hemodialysis:
Augmentin 250mg/31.25mg powder for oral suspension should only be used in patients with creatinine clearance higher than 30 ml/min.
Augmentin dose for patients with liver failure:
There is no recommended dose for this patient. Prescribing caution should be exercised and liver function should be checked periodically to adjust the dose as necessary.
4. How to take Augmentin
When using Augmentin, the patient should swallow the tablet whole and not chew it. If the tablet cannot be swallowed whole, the tablet may be broken in half and swallowed. Chewing the tablet may affect the bioavailability of an orally administered drug.
For the time of taking the drug, it should be taken at the beginning of a meal to minimize the risk of drug intolerance through the gastrointestinal tract. The absorption of Augmentin is optimal when taken at the beginning of a meal. In addition, antibiotics should not be treated for more than 14 days without consulting a doctor.
With Augmentin powder for suspension, follow these steps:
Tear off the corner of the pack and pour the powder into the glass. Pour a sufficient amount of water into the pack to remove the leftovers. Pour the water from the pack into the glass. Stir the medicine for a few seconds and drink it immediately. For children under 2 years of age, Augmentin suspension can be diluted up to 2 times. If the patient forgets to take a dose, take it as soon as possible after remembering. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Avoid taking twice the recommended dose.
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