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Chymodiactin is a drug that destroys the nucleus pulposus of the disc, usually indicated for direct injection into the disc in cases of non-surgical hernia. So what is the mechanism of action and main use of the drug?
1. What is Chymodiactin?
Chymodiactin has the main ingredient Chymopapain - a substance isolated from the raw latex of the Carica papaya fruit. Before harvesting, the green fruit is 6 to 10cm in diameter, the solution is pressed, and then through the extraction process, an extracellular protease similar to papain is isolated.Injecting Chymodiactin into the disc is a simple, minimally invasive, disc-preserving and highly effective procedure in many cases of acute pain due to herniation, reducing the frequency of patients having to undergo spine surgery.
After injecting the drug into the interior of the disc, it will break down macromolecules of glycoproteins and proteoglycans (the main components of the nucleus pulposus); causing loss of glycosaminoglycan and water, thereby causing the disc to shrink and reduce pressure on nerve roots; remove the nucleus leaving the annulus intact. At the same time, injecting Chymodiactin into the space around the spinal cord also has anti-inflammatory effects, temporarily reducing pain in damaged roots or nerves.
Although this is a highly effective treatment method, many complications still occur due to subjective and objective factors. Therefore, at present, Chymodiactin injection is rarely indicated.
2. Indications of the drug Chymodiactin
The drug Chymodiactin is indicated for use in the following cases:
Used as a protein for injection into the disc in the pathology of herniated discs that are torn or not torn, causing compression of the nerve roots. Reduce pain, reduce inflammation caused by disc compression of nerve roots.
3. Contraindications of the drug Chymodiactin
Do not use Chymodiactin injection in the following cases
Patients are allergic to Chymopapain, papaya or any other ingredient of the drug. The drug is used after local anesthesia of the spinal cord, so patients with a history of allergy to anesthetic drugs should not be used. Inflammation and infection of the injection site. Inflammation of the back spine, vertebrae collapse or vertebral fractures. Cancer pathology. The patient is being treated for coagulation disorders and is taking anticoagulants. Patients with advanced peptic ulcer disease, gastric bleeding. Diabetes, high blood pressure uncontrolled blood sugar and blood pressure. There is insufficient evidence to ensure safety in children, so Chymodiactin should only be used in adults. Pregnant and lactating women are not contraindicated to use Chymodiactin.
4. Drug Interactions of Chymodiactin
Tobacco, alcohol and alcoholic foods can affect the bioavailability of the drug. Therefore, before treatment with Chymodiactin should stop using these foods for at least 12 hours. There are not enough studies demonstrating the drug interactions of Chymodiactin with other drugs. However, if you are taking any medicine before the injection, you must inform the treating doctor.
5. Dosage and how to use Chymodiactin
How to use
Chymodiactin is in the form of an injection. Used to inject directly into the disc for therapeutic purposes. Before the injection, the patient should not eat or drink for a few hours and take an enema to clean the stomach. The doctor takes a CT scan - Scans the spine to determine the injection site. Before injecting Chymodiactin directly into the disc, an epidural analgesia is required to relieve the patient's pain. Dosage
Depending on the patient's condition and the degree of hernia and the doctor will have different dosage indications. Medicines are only prescribed and made mandatory by specialized doctors at medical facilities with full equipment. Test drug reactions before administering to patients to prevent severe allergic reactions.
6. Chymodiactin side effects
Some unwanted effects may be encountered when taking Chymodiactin medicine
Anaphylaxis, respiratory failure, fatigue, shortness of breath, tachycardia. Gastrointestinal cramps, abdominal pain, constipation, vomiting. Convulsions . Urinary incontinence, decreased urine output. Rapid shallow breathing, severe headache. Pain, swelling, change in skin color at the injection site. Rash, red, itchy skin all over the body or at the injection site. Lower limb paralysis. In summary, Chymodiactin is a drug injected directly into the disc in herniated pathology, the purpose of which is to relieve pain and reduce nerve root compression due to herniation. Currently, due to many dangerous side effects that can occur and the method requires an epidural, doctors rarely order it.
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