Rifater drug: Uses of the drug, indications and notes when taking the drug

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Rifater is used to treat pulmonary tuberculosis. The drug contains 3 antibiotics including rifampin, isoniazid and pyrazinamide.

1. What is the effect of Rifater?

Rifater is used to treat pulmonary tuberculosis. The three ingredients in the drug, rifampin, isoniazid and pyrazinamide, are all antibiotics. This medicine works by stopping the growth of TB bacteria. This antibiotic treats bacterial infections. It will not work for viral infections (such as the common cold or the flu). Using any other antibiotic when not needed and not prescribed by a doctor can cause antibiotic resistance in subsequent uses.
2. How to use Rifater The drug is prepared in the form of a sugar-coated tablet, round shape and for oral administration. Take Rifater one hour before a meal or two hours after a meal, the usual dose is once a day or as directed by your doctor. If you also take an antacid, take it at least 1 hour before taking the antacid so it doesn't lose its effectiveness. The dose of Rifater will be based on your age, weight, medical condition, and how well your body responds to treatment.
Continue taking this medicine until the prescribed dose is finished, even if the symptoms have disappeared. Stopping the medication too soon or skipping a dose can allow bacteria to continue to grow, which can lead to a return of the infection and make the infection more difficult to treat due to drug resistance. In addition to taking drugs, it is possible to use vitamin B6 in combination. Isoniazid may interact with foods containing tyramine and histamine (such as some fish). This interaction can cause increased blood pressure, red skin, headache, dizziness, or an irregular heartbeat. Contact your doctor to find out the most suitable treatment.

3. Undesirable effects when using Rifater

The use of Rifater, can cause side effects, including:
Nausea or vomiting. Heartburn. Stomachache. Muscle pain, mild joint pain. Headache. Causes urine, sweat, saliva, or tears to change color (yellow, orange, red, or brown). This effect is harmless and goes away when the drug is stopped. Unwanted side effects, including numbness, tingling in the arms and legs, joint pain or swelling. Rare but serious side effects include:
Rare but serious side effects include signs of kidney problems (such as changes in the amount of urine, urine with blood), increased thirst, frequent urination, vision changes, heart palpitations, easy bruising and bleeding, mental/mood changes (such as confusion, psychosis), seizures. Serious intestinal conditions such as diarrhea associated with Clostridium difficile or a drug-resistant bacteria. Do not use antidiarrheal or opioid medications if you have the following symptoms: persistent diarrhea, abdominal or stomach pain, cramps, blood or mucus in your stools. Symptoms of a serious allergic reaction, including fever that does not go away, swollen lymph nodes, rash, itching or swelling (especially of the face, tongue, or throat), dizziness, severe difficulty breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, call your doctor for help promptly.

4. Some things to note when using Rifater

Tell your doctor or pharmacist if you are allergic to rifampin, isoniazid or pyrazinamide, to other rifamycins (such as rifabutin, rifapentine) or to other body allergies. Tell your doctor or pharmacist your medical history, especially of a serious reaction to isoniazid, liver disease, kidney disease, heavy alcohol use, HIV infection, diabetes, gout, high uric acid levels in the urine. blood, numbness or tingling in the arms or legs (peripheral neuropathy), recent childbirth, a certain blood disorder (porphyria). Before having other surgery on your body, tell your doctor or dentist about all the products you use including over-the-counter medicines. Do not receive any vaccinations or immunizations while using Rifater unless directed to do so by your doctor. For pregnant women and lactating women, extreme caution should be exercised when taking the drug. For pregnant women in the last week of pregnancy, taking the drug can cause bleeding in the mother and baby. It is important to consult your doctor to safely use Rifater for both mother and baby.

5. Drug interactions

Possible drug interactions when taking these drugs together include:
Acetaminophen Carbamazepine Disulfiram MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, Rifater Dacarbazine, rasagiline, safinamide, selegiline, tranylyRifateromin ), SSRI antidepressants (such as fluoxetine, sertraline), valRifateroic acid. Rifampin may speed up the removal of other medicines from your body, which may affect how they work. Affected drugs include digoxin, nimodipine, phenytoin, ranolazine, rifater Aziquantel, tacrolimus, theophylline, certain anti-infectives (including chloramphenicol, clarithromycin, dapsone, doxycycline, linezolid, telithromycin, zidovudine, some quinolone antibiotics such as cip) itraconazole, ketoconazole), blood thinners (such as warfarin), Calcium channel blockers (such as diltiazem, verapamil), HIV NNRTIs (such as delavirdine, etravirine, nevirapine), HIV Rifaterotease inhibitors (such as atazanavir, ritonavir, saquinavir), among others. Medicines can reduce the effectiveness of hormonal birth control such as the pill, patch, or ring. This medication may interfere with certain laboratory tests (including folate, vitamin B12 levels, glucose tests, urine ketones).

6. How to store Rifater

Store the medicine in a dry, ventilated place, avoid direct sunlight on the medicine, avoid wet places such as the bathroom, next to the nebulizer to avoid affecting the quality of the medicine. Do not let children and pets arbitrarily play or throw drugs around. For expired drugs or to be disposed of, the manufacturer's disposal instructions should be followed to avoid harming the environment.

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Reference source: webmd.com