Precautions while using Uloric

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1. What is Uloric?

What is Uloric? Uloric contains the active ingredient Febuxostat, which is used to treat gout. Uloric is made in the form of tablets with the strength of 40mg, 80mg.
Mechanism of the drug Uloric: Gout is manifested by sudden pain, swelling, redness and pain in one or more joints caused by too much uric acid accumulation in the body. Normally, uric acid dissolves in the blood and is excreted in the urine. When you have gout, the blood cannot dissolve all uric acid, gradually forming solid crystals in the joints, causing pain and inflammation. Uloric suppresses urate production, thereby reducing serum urate levels, allowing crystals to begin to dissolve and preventing gout progression in the long term.
Uloric and Allopurinol have a similar mechanism of action, but Uloric should only be used when the patient does not respond to Allopurinol or has too many unwanted effects from the drug.

2. What does Uloric do?

Uloric drug is used to treat gout, acute gout attacks, chronic hyperuricemia in gout patients. Uloric drugs work to prevent damage to joints, prevent the progression of gout. Uloric drugs help reduce the size of gout, gout tumors, reduce the impact of gout on daily activities. Uloric is indicated for the treatment of gout unresponsive to Allopurinol or intolerant to Allopurinol.

3. Dosage and usage of the drug Uloric

Dosage of Uloric drug is calculated according to each patient's condition. Take Uloric at the dose recommended by your doctor.
Dosage of Uloric
Initial dose: 40 mg/day May be increased to 80 mg/day after 2 weeks if serum uric acid level below 6 mg/dL is not achieved. Dosage of Uloric for people with renal impairment
Mild to moderate renal impairment (CrCl 30-89 mL/min): keep the same dose as usual. Severe renal impairment (CrCl < 30 mL/min): dose not to exceed 40 mg/day. Dosage of Uloric for people with liver failure
Mild to moderate hepatic impairment (Child-Pugh class A or B): keep the same dose as usual. Severe liver failure (Child-Pugh class C): there have been no reports of this case, so be careful before use. How to use the drug Uloric
Uloric drug is made in the form of tablets, the drug is used orally, when using the patient, take the medicine with filtered water. Reports indicate that food does not affect the absorption of the drug. Patients should not stop taking Uloric without consulting their doctor, as it may make their gout condition worse.

4. Undesirable effects of the drug Uloric

Common side effects of taking Uloric: joint pain, mild rash, nausea, liver problems. Serious side effects from taking Uloric: allergic reactions (hives, difficulty breathing, swelling of the face or throat). Serious skin reaction (sore throat, burning in eyes, skin pain, red rash, spreading cyanosis, blistering, peeling skin). Systemic reactions: fever, skin rash, swollen glands, flu-like symptoms, muscle pain, muscle weakness, unusual bruising, jaundice, yellow eyes. Patients should notify your doctor immediately if: Feeling light-headed, possibly fainting; Heart attack, fast, irregular heartbeat, chest pain, shortness of breath, pain spreading to the jaw or shoulder, fast heartbeat; Abdominal pain on the right side of the liver, stomach pain, extreme fatigue, dark urine, jaundice, yellow eyes; Symptoms of a stroke: sudden numbness or weakness in your limbs, difficulty speaking, severe headache; Problems with balance or vision.

5. Notes when using the drug Uloric

Before taking Uloric: tell your doctor if you have any heart problems, heart attack, stroke, liver or kidney disease, cancer, Lesch-Nyhan syndrome, money organ transplant history, pregnant or lactating. In these cases, it is necessary to weigh the benefits and side effects when using Uloric to treat Gout. When you start taking Uloric, you may experience more gout flares, at this point you should continue using Uloric. To treat symptoms, your doctor may prescribe non-steroidal anti-inflammatory drugs or colchicine to prevent flare-ups. Before starting treatment with Uloric, you should have liver function tests. If the index changes abnormally, treatment with Uloric can be stopped. Uloric can cause heart problems, leading to a heart attack. Symptoms may include: chest pain, sudden dizziness, irritability, shortness of breath, cold sweats, nausea, vomiting, fatigue. Uloric can affect the flow of blood to the brain, possibly leading to a stroke. Symptoms may include: sudden numbness, weakness in the face, arm or leg, sudden severe headache, difficulty speaking, confusion, dizziness, trouble seeing, trouble walking, loss of balance. The US Food and Drug Administration (FDA) based on data obtained from clinical trials on the safety of the use of Uloric has concluded: there is an increased risk of death when Use Uloric compared to other gout medications such as Allopurinol. This conclusion suggests that the use of Uloric increases the risk of death from cardiovascular problems and other causes. As a result, the FDA is updating the information to include a prominent and affixed warning to instruct patients to use Uloric.

6. Uloric drug interactions

Concomitant administration of Uloric with drugs metabolized by azathioprine, xanthine oxidase, or mercaptopurine may increase the concentration of these drugs and cause serious toxicity.
Therefore, in order to avoid drug interactions, patients need to inform their doctors about the drugs, herbs, and functional foods being used so that the doctor can consider and prescribe appropriate drugs. Uloric is a drug used to treat gout. However, the drug has many undesirable effects, patients should not arbitrarily use the drug but must follow the doctor's instructions. For gout, in addition to taking medication, you should also change your diet and lifestyle to improve the effectiveness of treatment.
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