Allopurinol-lesinurad: Uses and dosages

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To treat gout effectively, reducing the amount of uric acid in the blood is the most effective way in combination with a balanced diet to help improve symptoms of the disease. Allopurinol-lesinurad is a combination medicine that limits or eliminates the amount of uric acid in the kidneys. It is prescribed by doctors to treat gout.

1. Uses of allopurinol-lesinurad

Allopurinol-lesinurad drug is made in the form of tablets, the drug belongs to the group of analgesics, antipyretics, non-steroidal anti-inflammatory drugs. Medicines for the treatment of gout and joint diseases.
Allopurinol-lesinurad is a combination medicine that works on the principle of reducing or eliminating the amount of uric acid that causes gout, it is used when allopurinol is not effective enough to treat.

2. Dosage of allopurinol-lesinurad

Initial dose for gout patients: There are two doses used to treat gout, allopurinol 300mg-lesinurad 200mg and allopurinol 200mg-lesinurad 200mg, once daily depending on the direction of the pharmacist or specialist.
Dosage adjustment for renal patients:
Before treatment: Do not use the drug for patients with severe renal impairment, for patients with mild to moderate disorders, keep the original dosage. During treatment: Mild or moderate renal dysfunction remains the same dose with regular monitoring. Severe renal dysfunction requires discontinuation of the drug. If blood creatinine levels are higher than twice before treatment, treatment must be interrupted and the original dose must not be re-administered without a doctor's prescription. If the creatinine level is less than 2 times, it must be monitored regularly during the course of taking the drug.

Dosage adjustment in liver patients: If the disorder is mild to moderate, use the normal dose without adjustment. In case of severe disorder, it should not be used.

Other adjustments: If the patient is taking two drugs, azathioprine or mercaptopurine, the dosage of those drugs should be reduced to 1⁄3 to 1⁄4 of the usual dose.
Subsequent dose adjustments are based on response to therapy and symptoms of drug toxicity.

3. How to take allopurinol-lesinurad

Users should drink as prescribed by the doctor, usually once a day in the morning with 240ml of water. While taking this medication, drink plenty of water to help it work better.
Do not stop taking your medicine or take too little or more medicine than your doctor prescribes.
If the user is switching from other drugs such as lesinurad or allopurinol to this combination drug, they should be stopped completely to avoid causing an overdose.
During the course of using the drug, there will be several gout attacks, but the patient must not stop the drug if there are gout attacks because this drug takes time to remove uric acid.
While taking allopurinol-lesinurad, your doctor will prescribe a few other medicines such as ibuprofen, naproxen to prevent acute gout attacks while you are taking allopurinol-lesinurad.

4. Notes when using allopurinol-lesinurad

Before using the drug, you should note the following issues to avoid using the wrong way, leading to not promoting the effectiveness of the drug as well as experiencing side effects that affect your health:
Do not use If you are allergic to any of its ingredients, users of the drug with liver or kidney problems, cancer treatment, or a certain genetic condition Allergies to chemicals, dyes, animal hair and food should inform doctor before using the drug Users preparing for surgery or tooth extraction If you are pregnant, do not use the drug unless absolutely necessary There are no studies to show whether lesinurad passes into breast milk, but allopurinol passes into breast milk breast milk, so a nursing mother should consult a doctor before using this medicine You should store this medicine at room temperature, away from moisture and direct sunlight, out of reach of children. children and pets in the house. Do not drive or use machines because this medicine has the risk of causing drowsiness, avoiding unfortunate accidents. Do not drink alcohol while taking medicine

5. Allopurinol-lesinurad side effects

Allopurinol-lesinurad drug when used, users will experience some side effects as follows:
Stomach pain, nausea, diarrhea, drowsiness, numbness, tingling in the limbs, unusual weight loss, prolonged sore throat, fever or chills Loss of appetite, yellowing of eyes, stomach pain, dark urine Rare side effects such as sudden vision changes, difficulty speaking, trouble breathing, unusual sweating May cause rash, Drug allergies are rare, but if you have severe symptoms such as swelling, itching in the face, tongue or throat, severe dizziness, the user should go to the emergency room immediately.

The above is not an exhaustive list of the side effects you may experience during the use of the drug, but if you notice any abnormalities in your body after taking it, you should go to the nearest medical facility or hospital for treatment. check, avoid serious consequences that may occur.

6. Allopurinol-lesinurad drug interactions

Allopurinol-lesinurad drug, when interacting with other drugs, can reduce the effectiveness of the drug or increase unwanted side effects for users:
Reduce the effectiveness of birth control pills, you can get pregnant if using this medicine and pregnancy medicine at the same time. You should consult your doctor about reliable birth control pills when using this medicine.
Do not use aspirin while taking this medicine because aspirin can reduce the effectiveness of allopurinol-lesinurad unless you are prescribed by your doctor to use aspirin to treat a heart attack or prevent a stroke.
When overdosing or experiencing unwanted effects of the drug should notify the doctor or immediately go to the nearest medical facility for appropriate diagnosis and treatment plan.
Customers can directly go to Vinmec Health system nationwide to visit or contact the hotline here for support.

See more:
Learn about Gout Gout – Symptoms, treatment and prevention Beware of serious skin side effects of gout medicine Allopurinol Who should not eat crab? Benefits of buying drugs at the Vinmec Hospital Pharmacy System Launching the Vinmec Manual of Medicine 2019 Using drugs safely