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Pregabalin is structurally similar to the neurotransmitter GABA, but the mechanism of action is still unclear. This active ingredient is present in the drug Pregabalin 50mg. So what is the effect of Pregabalin 50mg, how is it indicated and how is it used?
1. What is Pregabalin 50mg?
Pregabalin 50mg is a product of Domesco Medical Import-Export Joint Stock Company, which is made in the form of a hard capsule with the main ingredient being Pregabalin with a content of 50mg with a sufficient number of excipients in 1 tablet.The packaging of Pregabalin 50mg, each box can have 1, 6 or 15 blisters, respectively, each blister has 10 pills.
2. What are the effects of Pregabalin 50mg?
Active ingredient Pregabalin has a similar structure to the CNS depressant GABA, but Pregabalin 50mg does not directly bind to GABA receptors (such as GABA-A or GABA-B) or Benzodiazepine receptors. , and at the same time did not increase the response of GABA on neurons, did not affect the concentration of GABA in the rat brain, and did not affect the withdrawal and degradation of GABA.
When entering the body, the drug Pregabalin 50mg binds to the central nervous tissue with high affinity at the α-δ position. Although the exact mechanism of action of Pregabalin 50mg is not fully known, this binding may be related to the analgesic and anticonvulsant effects of Pregabalin.
3. Indications and contraindications of Pregabalin 50mg
Pregabalin 50mg is indicated for the treatment of the following cases:
Combination of anticonvulsants in the treatment of partial seizures in adults; Pregabalin 50mg for generalized anxiety disorder; Pain relief from neurological causes such as diabetic peripheral neuritis or pain following herpes virus infection; In addition, the drug Pregabalin 50mg also supports the relief of muscle pain caused by fibrosis.
This product is contraindicated for use in people who are hypersensitive to Pregabalin or any of its ingredients.
4. Instructions for using Pregabalin 50mg
4.1. Dosage of Pregabalin Adults:
Adjunctive treatment of partial seizures: Initial dose is 150mg (3 Pregabalin 50mg tablets) orally daily, then may be gradually increased every week depending on response to 300mg ( 6 Pregabalin 50mg tablets) and a maximum of 600mg/day; Treatment of generalized anxiety disorder: Initial dose of 3 tablets of Pregabalin 50mg orally per day, then increased by 150mg every week to a maximum dose of 600mg/day; Pain relief due to neuritis or pain after Herpes virus infection: Recommended dose: 150-300mg, respectively 3-6 Pregabalin 50mg tablets, divided into 2-3 times a day; Initial dose: 150mg (3 Pregabalin 50mg tablets) orally per day, can be increased to 300mg/day within 1 week depending on efficacy and tolerability of the patient; In case it is still not effective after 2-4 weeks, the dose can be increased to 300mg/day and up to a maximum of 600mg/day, divided into 2-3 oral doses; Note that doses exceeding 300mg/day (corresponding to 6 pregabalin 50mg tablets) are only applicable to patients who can tolerate a dose of 300mg/day, due to the risk of side effects when used at high doses; Diabetic neuropathic pain: Initial dose 150mg corresponds to 3 tablets of Pregabalin 50mg orally per day, divided into 3 times; The dose may be increased in 1 week to the maximum recommended dose of 300mg/day in 3 divided doses; Note that increasing the dose of Pregabalin 50mg may not increase the benefit but the risk of more ADRs; Fibromyalgia: Initial dose 150 mg/day, increased after 1 week depending on response, up to dose and 450 mg/day if necessary. Pregabalin 50mg dosage in children: The safety and effectiveness of Pregabalin 50mg have not been established when used in children under 12 years of age and adolescents aged 12-17 years.
Pregabalin dosage 50mg for some other subjects:
Patients with renal failure need to adjust the dose according to ClCr as follows: ClCr: 30-60 ml/min: Start with a dose of 75mg/day (1.5 tablets of Pregabalin 50mg), increase for a maximum of 300mg divided orally 2 - 3 times per day; ClCr 15-30 ml/min: start with 25-50mg/day and max 150mg/day; split 2 times or 1 time only; ClCr less than 15ml/min: Start with 1⁄2 tablets of Pregabalin 50mg, up to 1.5 tablets and take only 1 time per day; Patients on hemodialysis: Patients should receive an additional dose of 25-100 mg of Pregabalin immediately after each 4-hour dialysis session. 4.2. How to take Pregabalin 50mg Pregabalin 50mg is in the form of hard capsules for oral use, divided into 2-3 times per day, before or after meals.
5. Pregabalin 50mg . side effects
Some common side effects of Pregabalin 50mg :
Peripheral edema; Dizzy; Drowsiness; Loss of dispatch; Headache; Weight gain; Dry mouth; Muscle tremors; Blurred vision, double vision; Increased risk of infection.
6. Note when using Pregabalin 50mg
While using Pregabalin 50mg, patients should be aware of the following issues:Anticonvulsants, including Pregabalin 50mg, often increase the risk of suicidal thoughts or behavior in people user. Therefore, patients should be closely monitored for signs of depression, suicidal tendencies, abnormal behavior changes during treatment with Pregabalin 50mg, and should be instructed on how to notify the doctor. doctor as soon as the above symptoms appear. Pregabalin 50mg should be used with caution due to side effects causing peripheral edema. When pregabalin 50mg is used in combination with Thiazolidinedione (an antidiabetic drug) there is a greater risk of weight gain and edema than when using the drug alone. Pregabalin 50mg causes dose- and duration-related weight gain. However, drug-induced weight gain was not associated with pre-treatment body mass index (BMI), sex, and age, nor was it associated with edema. Short-term controlled studies have shown that weight gain has no clinical effect on blood pressure levels, but the long-term effects on cardiovascular function have not been elucidated. For patients with pre-existing cardiovascular disease, Pregabalin 50mg should be used with caution because it may increase the risk of heart failure. Pregabalin 50mg drug affects the central nervous system with symptoms including drowsiness, dizziness, physical and mental decline in patients. Therefore, caution should be exercised when patient driving or operating machinery. Pregabalin 50mg may increase creatine phosphokinase (CPK) and may lead to paroxysmal (although rare) myoglobinuria. Patients should notify their physician when symptoms such as pain, muscle weakness, sensitivity to pain, especially when accompanied by fever and/or fatigue, malaise. The process of stopping Pregabalin 50mg should be gradual and gradually reduce the dose for at least 1 week before stopping the drug completely to limit the increase in seizure frequency. Pregabalin 50mg should be administered with caution to patients with a history of drug addiction, while monitoring for signs of drug abuse. A study in pregnant animals (rats, rabbits) of pregabalin was administered at doses that produced plasma concentrations 5 or more times the human exposure at the maximum recommended dose of 600 mg/day. Accordingly, the study resulted in an increased rate of fetal malformations and toxic manifestations of fetal development, including mortality, growth retardation, neurological and reproductive damage in the fetus. However, there are no adequate and well-controlled studies in pregnant women taking Pregabalin 50mg, so this should only be used when the benefits outweigh the risks. It is not known whether Pregabalin 50mg passes into breast milk, so it should be used with caution in nursing patients. Pregabalin 50mg may cause dizziness and drowsiness, which in turn may affect your ability to drive or use machines.
7. Drug interactions of Pregabalin 50mg
Pregabalin 50mg increases the concentration/effect of thiazolidinedione oral antidiabetic drugs, CNS depressants, methotrimeprazine and selective Serotonin reuptake inhibitors. The concentration/effect of Pregabalin 50mg is increased when used in combination with Droperidol, Hydroxyzine and Methotrimeprazine. The concentration and effect of Pregabalin 50mg are reduced when combined with Ketorolac (both nasal and systemic) and Mefloquine. Pregabalin 50mg has the main ingredient is Pregabalin 50mg with some excipients just enough in 1 tablet. Pregabalin 50mg is indicated for the treatment of some neurological diseases. To ensure effective treatment, users need to strictly follow the instructions of the doctor or pharmacist.
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