This is an automatically translated article.
The article was professionally consulted by Doctor Department of Gastroenterology - Endoscopy, Department of Medical Examination & Internal Medicine - Vinmec Central Park International General Hospital.
Nonalcoholic fatty liver disease can progress from asymptomatic to present with hepatitis and eventually cirrhosis. If not diagnosed and treated promptly, nonalcoholic fatty liver disease can have serious consequences. So what are the treatments for this disease?
If the patient does not have non-alcoholic steatohepatitis, does not have cirrhosis of the liver, then there is no need for drug treatment, focus on controlling a healthy diet and exercising regularly. In terms of diet, patients should limit foods and drinks with high fructose and cholesterol content, and increase green vegetables and fruits.
For patients without conditions but with risk factors such as: diabetes mellitus, persistent elevation of liver enzymes, necrotizing inflammation, metabolic disorders, drugs can be used to prevent disease progression.
For patients with nonalcoholic steatohepatitis, there is currently no specific and uniform regimen for treatment. Currently, when treating patients with steatohepatitis in the acute stage, there are 4 main directions: lifestyle changes, lowering blood lipids, increasing insulin sensitivity and using antioxidant agents.
Lifestyle changes: limit alcohol use, adopt a healthy diet and exercise regimen.
Patients should lose weight but slowly because rapid weight loss can make liver disease worse. Weight loss and increased physical activity can help improve liver enzymes, liver histopathology, and plasma insulin levels. In some reports, after bariatric surgery, levels of steatosis and insulin resistance were reduced. Use of lipid-lowering drugs: statins and fibrates are used to treat hyperlipidemia in subjects with chronic liver disease. In addition, fibrates have been shown to significantly reduce liver enzymes and insulin resistance. Lipids accumulated in liver tissue are mainly triglycerides, so pay attention to the use of fibrates. Combinations of fibrates and statins have been shown to be well tolerated and effective. Drugs that increase insulin sensitivity and some others: metformin, pioglitazone, rosiglitazone, betaine, ursodeoxycholic acid, losartan, pentoxifylline, orlistat... Antioxidant agents: Vitamins E and C: clinical trial studies Clinical studies have shown that the use of vitamin E reduces liver enzymes, the combination of vitamin E and pioglitazone shows improvement in liver histology, while the daily combination of vitamin E and vitamin C can significantly improve liver fibrosis but not liver fibrosis. beneficial in terms of necrosis. However, now that there is increasing concern about the increased mortality associated with the use of vitamin E and the lack of convincing evidence for its benefit in nonalcoholic steatohepatitis, the supplementation Vitamin E supplementation should be considered. Silymarin: has antioxidant and hepatoprotective properties. Probucol: lowers blood lipids, anti-oxidant, some clinical studies show that the drug has an effective effect on reducing liver enzymes, but liver histology has not been proven.
Treatment for nonalcoholic fatty liver disease still does not have a really effective regimen in the long term, it is important to change the lifestyle and treat the underlying conditions. To detect liver diseases early, you should have regular liver screening to have timely treatment directions, to avoid causing many dangerous complications.
Currently, Vinmec International General Hospital has Hepatobiliary Screening packages, which help detect Hepatitis Virus at an early stage even when there are no symptoms. In addition, the comprehensive hepatobiliary screening package helps customers:
Evaluate the liver's ability to work through liver enzyme tests; Evaluation of bile function; vascular nutrition; Early screening for liver cancer; Perform tests such as Total blood cell analysis, blood clotting ability, screening for hepatitis B, C Assessment of liver and biliary status through ultrasound images and diseases that are at risk of affecting liver disease / liver disease. more severe liver disease In-depth analysis of parameters to evaluate hepatobiliary function through laboratory and subclinical tests; the risk of affecting the liver and early screening for hepatobiliary cancer
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