Miscarriage, recurrent stillbirth linked to genetics?

This is an automatically translated article.

Article written by Doctor Ly Thi Thanh Ha - Vinmec High-Tech Center

Miscarriage, recurrent stillbirth is the loss of pregnancy three times in a row including unobserved miscarriage. There are many causes of this condition such as: abnormal uterus, immune factors, chromosomal abnormalities... Is genetics the cause of miscarriage, recurrent stillbirth or not? ?

1. What is a recurrent miscarriage (collectively referred to as Recurrent Pregnancy Loss - RPL)?

According to the European Society of Reproduction and Embryology (ESHERE) and the Royal College of Obstetricians and Gynecologists (RCOG), RPL is the state of three consecutive pregnancy loss, including biochemical miscarriage (not yet observed) .
Continuous miscarriage is divided into 2 types:
Primary consecutive miscarriage and secondary consecutive miscarriage. Primary recurrent miscarriage is a condition in which a woman has never had a baby before. Secondary consecutive miscarriage is a condition in which a woman has successfully delivered a baby and raised it normally, then has recurrent miscarriages in subsequent pregnancies.

2. What are the causes of recurrent miscarriage?

2.1 Chromosomal Abnormalities In fact, up to 90% of women who experience recurrent miscarriages are directly related to chromosomal abnormalities, either from their spouses, or both. husband and wife or due to an error when the zygote divides to form an embryo.
2.2 Due to immune factors Women with autoimmune disorders will affect the process of transferring blood and nutrients from the body through the placenta to the fetus, causing the fetus to stop providing nutrients and not develop Okay.
When you have an autoimmune syndrome, before you become pregnant, you will have microvascular embolism, making it impossible for nutrients to pass to the fetus.
2.3 Abnormal uterus Common abnormalities in women's uterus such as: malformation, unicornuate, uterine adhesions due to unsafe abortion, uterine septum, cleft cervix, fibroids uterus ... will be the cause of repeated miscarriages .

2.4 Hormonal abnormalities Women with polycystic ovaries, luteal insufficiency, do not produce enough progesterone to nourish the fetus, causing embryo failure, stillbirth.
2.5 Women with medical diseases Cases of thyroid disease, diabetes, cardiovascular disease also affect the development of the fetus in the first 3 months, consecutive miscarriages can happen.
2.6 Having sexually transmitted diseases Women suffering from bacterial infections, sexually transmitted diseases such as gonorrhea, syphilis, warts, genital herpes, rubella virus infection, Salmonella... also causing recurrent miscarriages.
2.7 Sperm malformations Sperm quality in men is not guaranteed, sperm is broken, malformations also cause the fetus to stop developing when it has just formed.

2.8 Inherited clotting factor deficiency Many recent studies have shown a link between inherited clotting disorders and late-stage miscarriage (and stillbirth), possibly due to thromboembolism. placental bow.
2.9 Unknown Cause Up to 75% of women have recurrent miscarriages of unknown cause and do not need interventional treatment. The chance of getting pregnant again in the next time is about over 50% depending on the health of the pregnant woman.

Of the 7 main common causes of recurrent miscarriage in women, genetic causes are associated with RPL and need to be evaluated, and appropriate counseling and treatment measures considered. fit.
At Vinmec International General Hospital, there is a package maternity service as a solution to help pregnant women feel secure because of the companionship of the medical team throughout the pregnancy. When choosing Maternity Package, pregnant women can:
The pregnancy process is monitored by a team of qualified doctors Regular check-up, early detection of abnormalities Maternity package helps to facilitate the process. birthing process Newborns get comprehensive care