Matzim LA: Uses, indications and notes when using

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Matzim LA (diltiazem hydrochloride) is a nondihydropyridine calcium channel blocker used to treat high blood pressure (hypertension), to lower blood pressure.

1. Uses of Matzim LA

Diltiazem is used to treat high blood pressure (hypertension) and prevent chest pain (angina). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. When used regularly, diltiazem can reduce the number and severity of chest pain caused by angina. It can help increase your exercise capacity. Diltiazem is called a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, diltiazem dilates blood vessels and increases blood and oxygen supply to the heart while reducing its workload. Diltiazem also lowers your heart rate. These effects help the heart work less hard and lower blood pressure.

2. How to use Matzim LA

Matzim LA can be used alone or in combination with other antihypertensive drugs. Matzim LA is also used to improve exercise tolerance in patients with chronic stable angina.
Take this medication by mouth with or without food, usually once daily at the same time or as directed by your doctor. Do not crush or chew extended-release tablets. Doing so can release the drug all at once, increasing the risk of side effects. Also, do not split the tablets unless they have an index line and your doctor or pharmacist tells you to. Swallow whole or tablets without needing to crush or chew. Depending on your specific brand, take this medication in the morning or at bedtime as directed. Consult your pharmacist if you have any questions about when to take your medicine.
Your doctor will probably gradually increase your dose. Follow your doctor's instructions carefully. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, over-the-counter medicines, and herbal products).
Use this medicine regularly to get the most benefit from it. To help you remember, use it at the same time each day. Keep taking this medicine even if you feel well. Most people with high blood pressure do not feel sick. For the treatment of high blood pressure, it may take 2 weeks before you get the full benefit of this medicine.
This medicine must be taken regularly to prevent angina . It should not be used to treat angina when it occurs. Use other medicines (such as sublingual nitroglycerin) to relieve angina as directed by your doctor. Ask your doctor or pharmacist for more information.
Tell your doctor if your condition worsens (for example, your chest pain gets worse or your usual blood pressure readings increase).

3. Use Matzim LA Correctly

This section provides information on the proper use of certain products that contain diltiazem. It may not be exclusive to Matzim LA. Please read carefully.
In addition to using this medication treatment for your high blood pressure may include weight control and changes in the foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these is most important to you. You should check with your doctor before changing your diet.
Many patients with high blood pressure will not notice any signs of a problem. In fact, many people can feel normal. It is very important that you take your medicine exactly as directed and keep your doctor's appointments even if you feel well.
Remember that this medicine will not cure your high blood pressure, but it will help control it. You must continue to take your medication as directed if you want to lower your blood pressure and maintain it. You may need to take high blood pressure medication for the rest of your life. If high blood pressure is left untreated, it can cause serious problems like heart failure, blood vessel disease, stroke, or kidney disease.

4. Before using Matzim LA

When deciding to use a drug, the risks of taking the drug need to be weighed against the benefits it offers. This is a decision for you and your doctor. For this medicine you need to consider the following:
Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this or any other medicine. Also tell your healthcare professional if you have any other allergies, such as to foods, dyes, preservatives or animals. For over-the-counter products, read labels or packaging ingredients carefully.
Pediatrics Appropriate studies have not been performed on the relationship of age to the effects of diltiazem in children. Safety and effectiveness have not been established.
Geriatrics Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of diltiazem in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving diltiazem.
Breastfeeding Studies in women have shown that this medicine poses minimal risk to the infant when used during breast-feeding.

5. Drug interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction is possible. In these cases, your doctor may want to change the dosage or take other precautions. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
It is not recommended to take this medicine with any of the following medicines. Your doctor may decide not to treat you with this medicine or change some of the other medicines you are taking.
Cisapride Colchicine Eliglustat Flibanserin Lomitapide Using this medicine with any of the medicines below is generally not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change how much or how often you use one or both medicines.
Abametapir Acalabrutinib Acebutolol Alfentanil Alprenolol Amiodarone Aprepitant Atazanavir Atenolol Atorvastatin Avapritinib Benzhydrocodone Betaxolol Bevantolol Bisoprolol Bosutinib Brexpiprazole Brigatinib Bucindolol Buprenorphine Carbamazepine Carteolol Carvedilol Celiprolol Ceritinib Cilostazol Clarithromycin Clonidine Clopidogrel Clozapine Cobimetinib Codeine Conivaptan Crizotinib Cyclosporine Dantrolene Deflazacort Digoxin Dihydrocodeine Dilevalol Domperidone Doxorubicin Doxorubicin Hydrochloride Liposome Dronedarone Droperidol Elexacaftor Encorafenib Entrectinib Epirubicin Eplerenone Erythromycin Esmolol Fentanyl Fingolimod Fosaprepitant Fosnetupitant Hydrocodone Ibrutinib Ifosfamide Ivabradine Ivacaftor Ivosidenib Labetalol Lacosamide Lemborexant Levobunolol Lovastatin Lumateperone Lurasidone Lurbinectedin Meperidine Mepindolol Methadone Metipranolol Metoprolol Morphine Morphine Sulfate Liposome Nadolol Naloxegol Nebivolol Netupitant Nilotinib Olaparib Oxprenolol Oxycodone Pe migatinib Penbutolol Pentazocine Pexidartinib Pindolol Piperaquine Pixantrone Propranolol Ranolazine Rimegepant Selpercatinib Selumetinib Simeprevir Simvastatin Siponimod Sonidegib Sotalol St John's Wort Sufentanil Tacrolimus Talinolol Tazemetostat Tertatolol Tezacaftan Timeprevan Timolol Tolvapge

Using this medicine with any of the following medicines may increase your risk of some side effects, but using both medicines may be the best treatment for you. If both medicines are prescribed together, your doctor may change how much or how often you take one or both medicines.
Alfuzosin Buspirone Cimetidine Colestipol Dalfopristin Digitoxin Dutasteride Efavirenz Enflurane Fosphenytoin Guggul Indinavir Lithium Methylprednisolone Midazolam Moricizine Nevirapine Phenytoin Quinupristin Rifampin Rifapentine Sirolimus Suvorexant Triazolam Interactions with food/alcohol Some foods/drugs point to eat food or eat certain foods because interactions can occur. Using alcohol or tobacco with certain medications can also cause interactions. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Other medical problems The presence of other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially of:
Severe bowel obstruction Congestive heart failure - Use with caution. Can do bad conditions. Heart attack Heart block (type of irregular heartbeat, can be used if a pacemaker is working properly) or Hypotension (low blood pressure), severe Lung problems (eg, lung congestion) sick sinus (type of irregular heart rhythm, can be used if a pacemaker is working properly) - Should not be used in patients with these conditions. Kidney disease Liver disease - Use with extreme caution. The effects may be increased because the drug is removed from your body more slowly.

6. Dosage of Matzim

The dose of this medicine will be different for different patients. Follow your doctor's orders or directions on the label. The following information will include only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to.
The amount of medicine you take depends on the strength of the medicine. Also, the number of doses that you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking the medicine.
For chest pain: For oral dosage form (extended-release capsule): Adults - At first, 120 milligrams (mg) once daily in the morning. Your doctor can adjust your dose if needed. Children - Use and dosage need to be determined by your doctor. For oral dosage form (extended-release tablets): Adults - At first, 180 milligrams (mg) once daily, morning or evening. Your doctor may adjust your dose if necessary. Children - Use and dosage need to be determined by your doctor. For oral dosage form (tablets): Adults - At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if necessary. Children - Use and dosage need to be determined by your doctor. For high blood pressure: For oral dosage form (extended-release capsule): Adults - At first, 180 to 240 milligrams (mg) once daily in the morning. Your doctor may adjust your dose if necessary. Children - Use and dosage need to be determined by your doctor. For oral dosage form (extended-release tablets): Adults - At first, 180 to 240 milligrams (mg) once daily, in the morning or at bedtime. Your doctor may adjust your dose if necessary. Children - Use and dosage need to be determined by your doctor. Missed dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your usual dosing schedule. Do not double the dose.
Storage Store the medicine in the sealed container at room temperature, away from heat, moisture and direct light. Not frozen.
Keep out of reach of CHILDREN.
Do not keep medicine that has expired or is no longer needed.
Ask your healthcare professional how you should dispose of any medications you are not using.

7. Matzim LA side effects

Along with the necessary effects, the drug can cause some unwanted effects. Although not all of these side effects are possible, if they do, they will likely require medical attention.
Tell your doctor right away if any of the following side effects occur:
More common
Body aches Congestion Dry cough or sore throat Fever Hoarseness Runny nose Soft glands or swelling in the neck Difficulty swallowing Voice changes Less common Chest pain or discomfort Chills Diarrhea Difficulty breathing or shortness of breath Feeling faint, dizzy or lightheaded Feeling warm or hot Flushing or red skin, especially on the face and neck General discomfort or illness Headache Joint pain Loss of appetite Muscle aches Nausea Shivering Slow or irregular heartbeat Sweating Swelling of hands, ankles, feet or Legs Chest tightness Difficulty sleeping Unusual fatigue or weakness Vomiting Incidence unknown Blistering, peeling or loose skin Itching Large, rash-like swelling on face, eyelids, lips, tongue, neck throat, hands, feet, feet or genitals No heartbeat Red skin lesions, often with purple centers Red eyes, discomfort Sores, sores, or white spots in mouth or on lips

Some side effects may occur that usually do not require medical attention. These side effects may go away during treatment as your body adapts to the medicine. In addition, your healthcare professional will likely tell you about ways to prevent or reduce some of these side effects. Check with your healthcare professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Sneezing Nasal congestion Less common
Sour or sour stomach gas Constipation Continued ringing or buzzing or other unexplained noises in the ears Degenerative diseases Difficulty with movement Hearing loss Heartburn Indigestion Lack or loss of strength Muscle pain or cramps Muscle pain or stiffness Pain or soreness around eyes and cheekbones Rash Stomach upset or pain Joint swelling Incidence not known
Hair loss or thinning Other side effects not listed which can also occur in some patients. If you notice any other effects, call your doctor right away.

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Reference sources: webmd.com, drugs.com