This is an automatically translated article.
L-ornithine L-aspartate (LOLA) is a stable salt form of two amino acids ornithine and aspartic acid, indicated in acute and chronic liver diseases, such as cirrhosis, fatty liver, hepatitis, associated with increased blood ammonia, especially in neurological complications (hepatic encephalopathy). LOLA stimulates the synthesis of urea and glutamine rings, which play an important role in the detoxification mechanism of ammonia.
There are still many disagreements about the anti-ammonia effect of LOLA. In Vietnam, about 100 drugs with active ingredient L-ornithin L-aspartate are being circulated on the market with preparations in the form of injection (injection solution, infusion solution, concentrated solution for infusion) and sugar. oral (capsules, tablets, syrup,...).
1. Drug interactions
Currently, there are no reports of drug interactions between this drug and other drugs, but to ensure safety, patients need to fully provide their doctors with the drugs they are taking for advice on treatment use. When two or more drugs are used concurrently, interactions with synergistic or opposing effects may occur. Care should be taken when co-administering drugs to limit adverse interactions. Patients should fully list the treatment drugs, vitamins, herbs, supporting pills and functional foods they are using recently so that doctors and pharmacists can know and advise accurately to avoid drug interactions that are not beneficial to the patient.
2. Effects of the drug L-ornithine L-aspartate
L-ornithine What is L-aspartate? L-ornithine L-aspartate stimulates the synthesis of substances such as urea and glutamine, reduces the concentration of free ammonia, plays an important role in ammonia detoxification. Enhance liver detoxification.
Dosage - how to use : according to the instructions of the doctor.
Precautions when taking the drug:
In case the drug is prescribed in high doses, it is necessary to regularly check the concentration of the drug in the blood and urine. Dosage should be reduced in patients with severe renal impairment Children, the elderly, pregnant and lactating women
3. Indications and contraindications when taking l-ornithin l-aspartate
Indications:
Support the treatment of some liver diseases such as chronic hepatitis, alcoholic hepatitis. Treatment of disorders initiated in hepatic pre-coma, hepatic coma. Conditions of hyperammonemia in liver diseases: acute and chronic hepatitis, cirrhosis, fatty liver, hepatic encephalopathy. Contraindications :
Hypersensitivity to the components of the drug. CKD . Patients with lactic acidosis, Methanol poisoning, Fructose - sorbitol intolerance, Fructose 1,6 - diphosphatase deficiency
4. Side effects of the drug L-ornithin L-aspartate
Besides the effects of the drug, patients who are treated with the drug may also experience some unwanted effects. However, because the drug is quite safe and benign, there are currently no adequate studies on the side effects of the drug. During the course of treatment with the drug, if any unusual signs appear that are suspected to be due to the use of the drug, the patient should consult a pharmacist or treating doctor for timely and appropriate treatment. exactly.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
