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On the market today there is a lot of information about the drug Gliatilin intravenous injection, but these data are not really complete. So what is Gliatilin 400mg and how does it work?
1. What is Gliatilin 400mg?
Gliatilin 400mg has the main ingredient Choline alfoscerate (alpha Glycerylphosphorylcholine or Alpha-GPC), packaged in the form of a soft capsule with a strength of 14 tablets of 400mg, manufactured by Italfarmaco S.p.A. - Spain. The drug belongs to the group of nerve tonics, effective in the treatment of dementia, traumatic brain injury, and stroke.Choline alfoscerate is a choline-containing nootropic phospholipid. Choline alphoscerate increases acetylcholine release in the hippocampus in rats, facilitates learning and memory in laboratory animals, improves brain conduction mechanisms, and reduces age-dependent structural changes that occur. in rat brain regions involved in learning and memory. This compound has CNS protective effects in patterns of altered cholinergic neurotransmission and cerebrovascular injury. In clinical studies, choline alphoscerate improved memory and attentional impairment, as well as somatic and affective symptoms in dementia disorders.
2. What is the mechanism of action of Gliatilin 400 mg?
Gliatilin - Nootropic drug with mainly central nervous system effects. The release of choline from the active substance occurs in the brain; choline participates in the biosynthesis of acetylcholine (one of the main mediators of nervous excitement). Alfoscerate is biotransformed to glycerol phosphate, which is a precursor to phospholipids.
Acetylcholine improves the transmission of nerve impulses and glycerophosphate is involved in the synthesis of phosphatidylcholine (membrane phospholipid). As a result, membrane elasticity and receptor function are improved.
Gliatilin increases cerebral blood flow, enhances metabolism and activates the structures of the reticular formation of the brain, as well as restores consciousness during traumatic brain damage.
It has the effect of preventing and correcting the factors of psychosis syndrome, such as changes in the phospholipid composition of nerve cell membranes and a decrease in cholinergic activity.
Therefore, pharmacodynamic studies have shown that, Gliatilin acts on the synapse, conducting cholinergic nerve impulses (nerve transmission); plasticity of the neural membrane; sensory function.
2.1. Indications of the drug Gliatilin 400mg Acute phase of traumatic brain injury (including the case of impaired consciousness, coma); Cerebral circulatory disorders according to ischemic type (acute and convalescent phase) and hemorrhagic type (recovery phase); Degenerative psychological syndromes and consequences of cerebrovascular insufficiency, such as primary and secondary disturbances of dementia functions, are characterized by memory impairment, confusion, disorientation, decreased motivation, initiative and ability to focus; Changes in the emotional and behavioral spheres: emotional instability, increased irritability, loss of interest; old man pseudo melancholia; Multi-infarct dementia. 2.2. Contraindication of Gliatilin 400mg Patients with a history of hypersensitivity to any component of the drug Gliatilin Women who are pregnant or intend to become pregnant: Studies have shown that Gliatilin is not teratogenic, not toxic. for embryos. However, to ensure the safest, mothers should not self-medicate without a doctor's prescription. The benefit of the drug should not be placed above the effect on the fetus. 2.3. Drug interactions Drugs when used together with Gliatilin 400mg may reduce the effect such as: anticholinergic drugs such as physostigmin, succinylcholine, tiotropium bromide, ipratropium bromide... Drugs when used together with Gliatilin 400mg will increase the effect such as: : group of cholinergic drugs such as muscatine, lobelin, nicotine, bethanechol, acetylcholine... 2.4. Undesirable side effects of Gliatilin 400mg Drugs for neurological treatment but can still cause mild side effects: dizziness, headache, nausea, dizziness (due to dopaminergic activation), reactions allergies...
As a rule, the drug is well tolerated even with prolonged use. If nausea occurs while using Gliatilin, the dose should be reduced.
If these side effects do not go away and get worse, you need to notify your doctor immediately for treatment or medical intervention if necessary.
3. How to use Gliatilin 400mg effectively?
3.1. Oral Patients should drink before meals, drink with plenty of water to limit the effect of the drug on the kidneys. Swallow the tablet whole, do not chew, crush or break the drug. Do not arbitrarily adjust the dose or use time compared to the recommendation, only do it when prescribed by the treating doctor. Always read the instructions carefully before use. 3.2. Intramuscular, slow intravenous injection Gliatilin intravenous administration requires close monitoring of the doctor in charge of treatment. In the event of an overdose, notify your physician immediately and seek professional help as quickly as possible.
4. Dosage of Gliatilin 400mg
Patients need to follow the doctor's instructions, the reference dose is given as follows:
Use 1 tablet / time x 2-3 times / day. Duration of medication: 4 weeks or longer depending on the patient's response. In chronic cerebrovascular insufficiency, altered emotional and behavioral domains and multi-infarct dementia, the drug is administered orally 400 mg (1 tablet) 3 times / day. The duration of treatment is 3-6 months. For oral administration, patients need to carefully read the instructions and follow the dose prescribed by the doctor. Never increase or decrease the dose on your own, even if your symptoms improve.
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