This is an automatically translated article.
The article was written by Pharmacist Nguyen Le Trang - Clinical Pharmacist of Pharmacy Department - Vinmec Times City International HospitalThe beta sympathomimetic group inhibits beta adrenergic receptors, including: beta1, beta2, beta3, in which the most clinically applicable are beta1 and beta 2 receptors. Beta 1 receptors are abundant on the heart and kidneys. Beta 2 receptors are abundant in bronchi, vascular smooth muscle, digestive, musculoskeletal... beta3 is found in fatty tissue, bladder, intestine.
1. Mechanisms and effects, classification of beta-blockers
Beta1 receptor blockers reduce heart rate, decrease myocardial contractility, decrease renin secretion, decrease water retention, and decrease circulating volume.Beta2 receptor blockade causes muscle contraction on peripheral blood vessels (such as tracheobronchial smooth muscle), increases gastrointestinal motility, decreases glycogenolysis, increases blood sugar, and blood lipids.
Classification:
Non-selective beta-blockers: propranolol (Avlocardyl, Dorocardil), low blood pressure lowering effect, but less slow heart rate, rarely used for cardiovascular indications. Main indications: esophageal varices, migraine prophylaxis, tremor due to hyperthyroidism. The group of selective beta-blockers: metoprolol (Betaloc), bisoprolol (Concor), Atenolol (tenormin) have better antihypertensive effect, fast, reduce tachycardia, are indicated in hypertension, angina pectoris, heart failure, arrhythmia. Non-selective beta-blockers and alpha1-blockers: labetalol, carvedilol, had better antihypertensive effect than the non-selective group alone. Selective beta1 blocker and vasodilator through NO release: nebivolol has a better antihypertensive effect.
Nhóm thuốc ức chế chọn lọc beta1 được sử dụng cho các chỉ định tim mạch
2. Unwanted effects and notes when using
Drugs cause low blood pressure when taking the drug or when the dose is increased, so it is recommended to change position slowly immediately after taking the drug Drugs that cause bradycardia, need to monitor heart rate Bronchospasm drugs should be used with caution in patients bronchial asthma patients when using non-selective groups >>> bronchospasm can use beta blockers?
Drugs can cause erectile dysfunction Drugs can mask hypoglycemia, so diabetics should be carefully monitored, especially patients using insulin, diamicron Drugs have a "rebound" effect When stopping suddenly, therefore, the dose should be reduced and the drug should be stopped according to the schedule.
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