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Posted by CCII Doctor Bui Thu Huong - Head of Emergency, Day Treatment Unit - Pediatric Center - Vinmec Times City International Hospital.Stomach ulcer in children is a disease that can affect the health and development of children, the successful treatment and eradication of H.pylori bacteria depends on many factors. .
1. Factors affecting the effectiveness of killing H.pylori
A number of factors can affect the effectiveness of killing H.pylori bacteria and the treatment results of peptic ulcers in children, including:
Antibiotic resistance in children The adherence to treatment of child: Duration of treatment Course of treatment Type of drug used Treatment cost of drug Side effects Bacteria: Degree of bacterial infection Virulent strain
Mức độ nhiễm khuẩn cũng làm ảnh hưởng tới hiệu quả điều trị bệnh ở trẻ
2. Drug choice when both treatment options 1 and 2 . fail
During the treatment of peptic ulcer disease, in case of failure with both regimen 1 and 2, it is necessary to have another treatment option, this is done by a specialist, some drugs to choose from include:
Amoxicillin + tetracycline + bismuth + PPI Levofloxacin + amoxicillin + PPI Rifabutin + amoxicillin + PPI (not applicable to children) Furazolidone + amoxicillin + PPI (not applicable to children)
3. Difficulty in applying treatment
Do not apply Tetracycline to children under 8 years of age Levofloxacin Belongs to the fluoroquinolone group, which is an antibiotic with a broad antibacterial spectrum against both gram-positive and gram-negative bacteria.
The levofloxacin regimen was effective in eradicating HP in 80% of studies in adults.
There is no recommendation to apply to children due to side effects of the drug affecting cartilage and bone development.
Furazolidone Is a synthetic nitrofuran antifungal drug.
High activity against H. pylori even when used alone and not in combination with other antibiotics.
Một số thuốc không khuyến cáo cho trẻ sử dụng vì có nguy cơ gây tác dụng phụ
The treatment efficacy of furazolidone + amoxicillin + PPIs was high in a multi-analysis in adults:
The first choice was 86% effective Option 2 was 76% effective Option 3 was effective for treatment treatment is 65% No studies and no recommendations for the use of furazolidone in the treatment of H. pylori infection in children
Rifabutin Derived from rifamycin - a tuberculosis drug
Used to treat H. pylori infection in adults resistance to other antibiotics gives a treatment effect of 69%
Using rifabutin is still a matter of consideration because of
High cost of treatment Complications of severe agranulocytosis and thrombocytopenia Multi-antibiotic resistance of bacteria TB is an issue that needs to be looked at carefully to avoid an increase in antibiotic resistance. There are no studies and no recommendations on the use of rifabutin in the treatment of H. pylori infection in children
Once the child has been diagnosed with peptic ulcer disease, the family must strictly follow the treatment regimens to prevent infection. drug resistance.
Cha mẹ cần nghiêm túc thực hiện theo pháp đồ điều trị để có hiệu quả trị bệnh tốt nhất
Pediatrics department at Vinmec International General Hospital is the address for receiving and examining diseases that infants and young children are susceptible to: viral fever, bacterial fever, otitis media, pneumonia in With modern equipment, sterile space, minimizing the impact as well as the risk of disease spread. Along with that is the dedication from the doctors with professional experience with pediatric patients, making the examination no longer a concern of the parents.
Customers can directly go to Vinmec Health system nationwide to visit or contact the hotline here for support.
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Gastroduodenal ulcers in children: Diagnosis and treatment Do not be subjective with peptic ulcers in children Principles of treatment of peptic ulcers in children
