Causes and mechanisms of autoimmune hepatitis

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The main cause of autoimmune hepatitis is not clear. In people with autoimmune diseases, the immune system attacks one or more parts of the body as a foreign factor. This causes inflammation and can destroy one or more of the body's affected organs.

1. Learn about autoimmune hepatitis

What is autoimmune hepatitis? This is inflammation in the liver that occurs when the body's immune system attacks the liver. Although the exact cause of autoimmune hepatitis is not clear, certain diseases, toxins, and medications can cause autoimmune hepatitis.
Some symptoms of autoimmune hepatitis include:
Abdominal pain ; nausea, vomiting Joint, muscle pain and fatigue Jaundice due to a buildup of bilirubin . In neonates, there are often physiological and pathological signs of jaundice. Childhood autoimmune hepatitis can cause jaundice in the first few days after birth.

2. Causes of autoimmune hepatitis

Autoimmune hepatitis is a rare cause of chronic hepatitis. Chronic hepatitis is a disease with necrotic lesions and inflammation occurring for more than 6 months. This condition will damage liver cells, leading to many serious problems for the patient.

However, the primary cause of autoimmune hepatitis is not clear. In people with autoimmune diseases, the immune system attacks one or more parts of the body as a foreign factor. This causes inflammation and can destroy one or more of the body's affected organs.
The following risk factors can cause autoimmune hepatitis :
Genetic factors Caused by some viruses such as: acute HCV A, HBV, Epstein-Barr virus Due to exposure to chemicals such as: : Interferon, Melatonin, Alpha methyldopa, Oxypanisatin, Nitrofurantoin, Tienilic acid Autoantigen-inducing factors such as: ASGPR (arialoglycoprotein receptor) and Cytochrome mono-oxygenase P-450 IID6

3. Mechanism of autoimmune hepatitis

The mechanism of formation of autoimmune hepatitis is due to the attack of the cell-mediated immune system. This attack against hepatocytes is genetically inherited
Besides, the abnormal presence of HLA class II human leukocyte antigen on the hepatocyte membrane makes normal liver cells become antigenic . This activates immune cells, stimulates the rapid production of T-lymphocytes, which are toxic to the body. This toxic T lymphocyte penetrates into the liver tissue and releases Cytokines that cause liver cell damage.
Currently, Vinmec International General Hospital has Hepatobiliary Screening packages, which help detect Hepatitis Virus at an early stage even when there are no symptoms. In addition, the Comprehensive Hepatobiliary Screening Package helps customers:

Assess the liver's ability to work through liver enzyme tests; Evaluation of bile function; vascular nutrition; Early screening for liver cancer; Perform tests such as Total blood cell analysis, blood clotting ability, screening for hepatitis B, C Assessment of hepatobiliary status through ultrasound images and diseases that are at risk of affecting liver disease / liver disease. more severe liver disease In-depth analysis of parameters to evaluate hepatobiliary function through laboratory, subclinical; the risk of affecting the liver and early screening for hepatobiliary cancer
To register for examination and treatment of hepatobiliary diseases at Vinmec International General Hospital, you can contact Vinmec Health System nationwide, or register online HERE.