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Acetaminophen and Codein Oral Solution (also known as Acetaminophen Codein for short) are used to relieve pain. Patients need to take medication as prescribed by their doctor to reduce the risk of unpredictable side effects.
1. Uses of the drug Acetaminophen Codeine
Acetaminophen and Codein Oral Solution are made in the form of an oral solution, used to relieve pain. The composition of the drug includes: Acetaminophen and Codeine Phosphate and other excipients.
Oral Acetaminophen Codeine Solution is indicated for the management of mild to moderate pain when opioid treatment is appropriate, other treatments are not suitable.
Painkiller Acetaminophen Codeine is contraindicated in the following cases:
Children under 12 years old; Postoperative treatment in children under 18 years of age after tonsillectomy or VA; People with respiratory failure; Patients with acute or severe asthma in unsupervised conditions, without resuscitation equipment; Concomitant use with monoamine oxidase inhibitors (MAOIs) or taking MAOIs within 14 days; Patients with known or suspected gastrointestinal obstruction, including paralytic ileus; Patients with hypersensitivity to Acetaminophen, Codeine or any other excipients in the drug's ingredients.
2. How to use and dose Acetaminophen and Codeine Oral Solution
Usage: Orally. The drug solution contains 120mg Acetaminophen and 12mg Codeine phosphate per 5ml (1 teaspoon). The medicine can be taken with or without food. If the medicine causes stomach upset, it should be taken with food.
Dosage: Adults take 15ml every 4 hours if needed.
Some important notes:
It is necessary to ensure accuracy when prescribing, dispensing and using Acetaminophen Codeine to avoid errors due to confusion between mg and ml as well as with oral solutions of different concentrations. ; Ensure dosage is clearly communicated and provided accurately, using a dedicated measuring spoon/cup; Use the lowest effective dose for the shortest period of time, consistent with the patient's treatment goals; Initiating a dosing regimen for each patient should take into account pain severity, response, prior experience in analgesic therapy, and risk factors for drug abuse and addiction; Closely monitor the patient for respiratory depression, especially within the first 24 - 72 hours after starting treatment and after increasing the dose; Do not stop abruptly in patients with opioid dependence. Stopping medication too suddenly can cause severe withdrawal symptoms, uncontrolled pain, and suicide. Missed dose: If you miss a dose of Acetaminophen and Codeine Oral Solution, you should take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
Overdose: If the drug overdose, the patient should call the doctor immediately, emergency and go to the hospital immediately. Acute overdosage with Codeine manifests as: respiratory depression, drowsiness, coma, tremor, cold and lumpy skin, pupillary constriction, pulmonary edema, hypotension, bradycardia, airway obstruction, Acetaminophen overdose can cause liver necrosis (easily lead to death), tubular necrosis, hypoglycemic coma, blood clotting problems. Initial symptoms after overdose of Acetaminophen include: Anorexia, nausea, vomiting, pale skin, irritability,... Based on the specific condition of the patient, the doctor will prescribe the method. appropriate treatment of overdose.
3. Acetaminophen Codeine side effects
Some common side effects of Acetaminophen Codeine include: Dizziness, drowsiness, weakness, fatigue, abdominal pain, constipation, dry mouth, headache, flushing, excessive sweating,... If these side effects make you feel tired, bothersome, or do not go away, you should tell your doctor.
In case of experiencing the following very serious side effects, the patient should immediately notify the doctor or need to be hospitalized for treatment immediately:
Signs of an allergic reaction: Rash, itching, redness of the skin, swelling, blistering, or peeling of the skin; fever; wheezing angina; feeling short of breath, trouble swallowing or talking, unusual hoarseness; swelling of the face, lips, tongue, throat; very severe dizziness or unconsciousness; Chest pain or heart palpitations ; Severe constipation or stomach pain - this is a sign of a serious problem in the digestive tract; Difficulty urinating or change in the amount of urine; fever, chills, sore throat, unexplained bruising or bleeding, feeling especially tired; Mood swings, vision changes, seizures; red or irritated eyes, sores in the mouth, throat, or nose; Serotonin syndrome can occur if you use Acetaminophen, Codeine with certain other medicines. You should call your doctor right away if you have agitation, confusion, hallucinations, fever, fast or irregular heartbeat, muscle twitching or stiffness, tremors, heavy sweating, stomach pain, severe diarrhea, vomiting, severe headache, ...
4. Be careful when using Acetaminophen and Codeine Oral Solution
Before taking Acetaminophen Codeine, patients should tell their doctor if:
Are allergic to the ingredients of the drug or to any other drugs or foods; Have health problems: Lung or respiratory disease such as asthma , shortness of breath, sleep apnea; high levels of carbon dioxide in the blood; diseases of the stomach or intestines; Are taking medications: buprenorphine, nalbuphine, butoranol or pentazocine; Have taken certain medications for depression or Parkinson's disease in the past 14 days: Isocarboxazid, tranylcypromine, phenelzine, selegiline, or rasagiline; Currently taking: Linezolid or methylene blue; Are pregnant or breastfeeding; Medications you are taking and other health problems. While taking Acetaminophen Codeine, patients should note:
Inform your doctor about your use of Acetaminophen Codeine; Avoid driving or doing things that require flexibility, alertness and concentration; To reduce the feeling of dizziness or fainting, you should change position slowly (eg from sitting to lying position) and need to be careful when going up/down stairs; You will be carefully monitored to make sure you do not abuse or become addicted to the drug; Allergic reactions have been recorded when taking Acetaminophen Codeine, so patients should notify their doctor if they see any signs; Avoid using other medicines that have Acetaminophen in them, check the drug labels closely because Acetaminophen overdose can cause liver problems; Follow your doctor's instructions on how to take and how much to take, and do not take more than recommended. You should call your doctor if you have taken too much Acetaminophen in a day even though you feel otherwise well; Acetaminophen Codeine may affect the results of some laboratory tests. Therefore, the patient should inform the medical examiner that he is taking this drug; Long-term use of an opioid medication can lower sex hormone levels. You should consult your doctor if you have low libido, fertility problems, no period (women) or sexual weakness (men); Acetaminophen Codeine may increase the risk of seizures in some patients, especially those who have had a seizure before. Patients should talk to their doctor about this risk; Using Acetaminophen Codeine can cause pathology in the adrenal gland. Patients should call their doctor right away if they experience severe dizziness, unconsciousness, abdominal pain, vomiting, feeling less hungry, very weak or very tired; Be careful when using the drug in people 65 years of age and older because more side effects may occur; Acetaminophen and Codeine Oral Solution can harm an unborn baby. If you are pregnant or find out that you are pregnant while taking this medicine, you should tell your doctor right away.
5. Acetaminophen and Codeine Oral Solution drug interactions
Some drug interactions Acetaminophen Codeine include:
CYP2D6 inhibitors: Paroxetine, bupropion, fluoxetine, quinidine; CYP3A4 inhibitors: Macrolide antibiotics (erythromycin), azole antifungals (ketoconazole) and protease inhibitors (ritonavir); CYP3A4 enzyme inducers: Rifampin, carbamazepine, phenytoin; Benzodiazepine or other CNS depressants: tranquilizers, anxiolytics, muscle relaxants, general anesthetics, antipsychotics,...; Serotonergic drugs; Monoamine Oxidase Inhibitors (MAOIs); Opioid pain relievers: Butorphanol, nalbuphine, pentazocine; Other drugs: Muscle relaxants, diuretics, anticholinergics,... When using Acetaminophen Codeine, patients should strictly follow the doctor's instructions. Patients should not start, stop, or change the dose of medication without their doctor's approval.
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