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Claminat drug is used in the treatment of some ear - nose - throat infections, lower respiratory tract infections, urinary tract infections, ... So how to use this drug?
1. Uses of Claminat 250mg/31.25mg
Claminat medicine 250mg / 31.25mg is produced in the form of powder packaging, the main ingredients in each package include:
Amoxicillin 250 mg Clavulanic acid 31.25 mg Amoxicillin is a semi-synthetic beta-type antibiotic - lactams have a broad bactericidal spectrum against many Gram-positive and Gram-negative bacteria by inhibiting bacterial cell wall synthesis. But the active ingredient Amoxicillin is easily destroyed by beta-lactamase enzymes, so it has no effect on strains of bacteria that produce these enzymes.
And ClavuLanic Acid has beta - lactam structure similar to Penicillin, capable of inhibiting beta - lactamase enzymes produced by most Gram-negative bacteria and Staphylococcus. In particular, clavulanic acid has a strong inhibitory effect on plasmid-transmitted beta-lactamase enzymes that cause resistance to penicillins and cephalosporins.
The combination of ClavuIanic acid and Amoxicillin in Klamentin 875/125 prevents Amoxicillin from being destroyed by beta-lactamases, and at the same time effectively expands the antibacterial spectrum of Amoxicillin against many types of bacteria normally resistant to Amoxicillin, other penicillins and cephalosporins.
2. Indications and contraindications of Claminat 250mg/31.25mg
Claminat medicine 250mg/31.25mg is indicated for use in the treatment of infections caused by sensitive bacteria, including:
Ear - nose - throat infections such as: tonsillitis, otitis media, sinusitis. Lower respiratory tract infections such as: Acute and chronic bronchitis, bronchial pneumonia; Genitourinary tract infections such as cystitis, pyelonephritis, urethritis, female genital tract infections. Skin and soft tissue infections such as boils, abscesses, wound infections, cellulitis. Bone and joint infections such as: Osteomyelitis. Dental infection: Alveolar abscess. Other infections such as: Obstetric bacteremia, abortion-associated infection, intra-abdominal infection. The drug Claminat 250mg/31.25mg is contraindicated in the following cases:
People who are sensitive to the components of the drug or antibiotics of the Penicillin, Cephalosporin group. People with a history of jaundice. People with liver failure. Phenylketonuria patient.
3. Dosage and how to use Claminat 250mg/31.25mg
How to use Claminat 250mg/31.25mg:
Claminat pack is used by mixing the powder in a little water before taking it. Claminat 250mg/31.25mg should be taken at the beginning of food to minimize drug intolerance in the gastrointestinal tract. Do not use Claminat 250mg/31.25mg for more than 14 days without reviewing the treatment. Dosage of Claminat 250mg/31.25mg is expressed according to the content of Amoxicillin in the combination drug.
Dosage of Claminat 250mg/31.25mg for adults and children over 40kg:
Usual dose: Use 01 sachet every 8 hours/time. In case of severe infections and respiratory tract infections: Use dose of 2 sachets every 8 hours for 5 days. Dosage of Claminat 250mg/31.25mg for children under 40kg:
Usual dose: Use a dose of 20mg Amoxicillin/kg body weight/day, divided into several times 8 hours apart. Treatment of sinusitis, otitis media, lower respiratory tract infections and severe infections: Use a dose of 40mg Amoxicillin/kg body weight/day, divided into several times 08 hours apart, for 5 days. For patients with renal impairment, the dose of Claminat 250mg/31.25mg should be adjusted according to the creatinine clearance.
Oral dose of Claminat 250mg/31.25mg for adults with kidney failure:
| Độ thanh thải Creatinin | Liều thuốc Claminat gói tính theo hàm lượng Amoxicillin |
| > 30 mL/phút | Không cần chỉnh liều |
| 15 - 30 mL/phút | Sử dụng liều thông thường cách nhau từ 12 - 18 giờ/lần. |
| 5 - 15mL/phút < 5mL/phút |
Sử dụng liều thông thường cách nhau từ 20 - 36 giờ/lần. Sử dụng liều thông thường cách nhau 48 giờ/lần. |
| Chạy thận nhân tạo | Sử dụng 02 gói giữa thời gian mỗi lần thẩm phân và thêm 02 gói sau mỗi lần thẩm phân. |
Oral dose of Claminat 250mg/31.25mg for children with kidney failure:
| Độ thanh thải Creatinin | Liều thuốc Claminat gói tính theo hàm lượng Amoxicillin |
| > 30 mL/phút | Không cần điều chỉnh liều. |
| Từ 10 - 30 mL/phút | Sử dụng liều 25mg/kg cân nặng, 2 lần mỗi ngày. |
| < 10 mL/phút | Sử dụng liều 25mg/kg cân nặng/ngày. |
Symptoms of Claminat 250mg/31.25mg overdose include abdominal pain, vomiting, diarrhea. A small number of patients have a rash, increased agitation or somnolence.
In case of overdose of Claminat 250mg/31.25mg, it is necessary to stop taking the drug immediately and treat symptomatically and provide supportive treatment if necessary. If overdose is detected early and there are no contraindications, the doctor may induce vomiting or gastric lavage.
Patients need to provide enough water and electrolytes for the body to maintain diuresis and reduce the risk of crystalluria. Renal damage in patients with overdose is reversible upon discontinuation of the drug. Hypertension can occur immediately in patients with compromised renal function.
Hemodialysis can be used to remove excess Amoxicillin and clavulanic acid from the circulation.
If you forget a dose of Claminat 250mg/31.25mg, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
4. Side effects of Claminat 250mg/31.25mg
When using Claminat 250mg/31.25mg, you may experience the following side effects.
Common side effects include: Diarrhea, itching, nausea, vomiting. Uncommon side effects include: eosinophilia, rash, hepatitis and cholestatic jaundice, increased transaminases. Rare side effects include: Anaphylaxis, hemolytic anemia, leukopenia, pseudomembranous colitis, Stevens-Johnson syndrome, interstitial nephritis. If an allergic reaction occurs to Claminat 250mg/31.25mg, Amoxicillin therapy should be discontinued and immediate emergency treatment with adrenaline, oxygen, intravenous corticosteroid therapy and ventilation, including intubation, is required. trachea and the patient was never treated with penicillin or cephalosporin again.
5. Interaction of Claminat 250mg/31.25mg with other drugs
Claminat medicine 250mg/31.25mg can cause prolongation of bleeding and clotting time. Claminat 250mg/31.25mg may decrease the effectiveness of oral contraceptives. Probenecid reduces the elimination of Amoxicillin but does not affect the elimination of clavulanic acid. Nifedipine increases the absorption of Amoxicillin. Patients with hyperuricemia when taking Allopurinol with Claminat 250mg/31.25mg will increase the possibility of Amoxicillin rash. Bacteriostatic substances such as: fusidic acid, chloramphenicol, tetracycline when used together with Claminat 250mg/31.25mg can reduce the bactericidal effect of Amoxicillin. Amoxicillin in Claminat 250mg/31.25mg reduces Methotrexate excretion, increases toxicity on gastrointestinal tract and hematopoietic system. Once you know the use of Claminat, you should use it appropriately to ensure its effectiveness and safety.
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