Acnotin 10 mg is a specialty medication prescribed for severe acne cases that do not respond to conventional therapies. This article provides detailed information about Acnotin 10, its uses, and instructions on proper administration.
1. What is Acnotin 10? What are its Ingredients?
Acnotin 10 is an acne medication manufactured by Mega Lifesciences, a well-known pharmaceutical company from Thailand. The company and its products are currently available in nearly 40 countries worldwide. In Vietnam, Mega Lifesciences has been operating since 1995 with reputable healthcare products such as Eugica, Ferrovit, and Nac C.
The main component of Acnotin is Isotretinoin, which is highly concentrated in each capsule. Specifically:
- Each Acnotin 10 mg capsule contains 10 mg of isotretinoin.
- Each Acnotin 20 mg capsule contains 20 mg of isotretinoin.
Additionally, each capsule includes inactive ingredients such as white beeswax, butylated hydroxyanisole, soybean oil, brilliant blue, disodium edetate, and sorbitol 76%. Currently, Acnotin is available in two forms: Acnotin 10 and Acnotin 20.
Isotretinoin's mechanism of action:
- Reduces the size and inhibits the activity of sebaceous glands, thus minimizing acne formation.
- Possesses strong anti-inflammatory properties.
The market price for Acnotin 10 is approximately 280,000 VND per box (containing 3 blister packs with 10 capsules per blister, totaling 30 capsules).
2. What is Acnotin 10 Used For?
Acnotin 10 or Acnotin 20 is prescribed to treat:
- Severe acne or full-body acne.
- Acne unresponsive to other conventional treatments.
- Acne that causes facial disfigurement or leaves deep scars.
- Persistent acne that negatively impacts mental health, communication, and daily life.
Additionally, Acnotin may have other approved uses not listed on the label, as specified by a physician.
3. How Should You Take Acnotin 10? What is the Dosage?
3.1 Instructions for Use
Take Acnotin 10 during meals. Swallow the capsule whole without chewing or crushing, as this can reduce the concentration of isotretinoin and compromise the drug's efficacy.
While on Acnotin, avoid excessive exposure to sunlight.
Do not combine Acnotin 10 with other acne treatments that exfoliate or peel the skin, whether oral or topical.
The treatment duration with Acnotin 10 usually lasts approximately 16 weeks. In the initial weeks, acne may worsen temporarily but will improve over time. For enhanced results, the doctor may prescribe additional treatments like adrenocorticoids.
The effectiveness of Acnotin is assessed after 8 weeks post-treatment, during which acne improvement is observed. If needed, treatment can be repeated.
3.2 Dosage Guidelines
For adults and adolescents, the standard dosage of Acnotin is 0.5–1 mg per kg of body weight per day.
Example: If you weigh 50 kg, the daily dose is 25–50 mg (2–3 capsules of Acnotin 10 mg), divided into 2 doses per day for 15–20 weeks.
In severe acne cases (e.g., back or chest acne), the doctor may prescribe a higher dose, up to a maximum of 2 mg per kg per day.
Acnotin is not recommended for children under 12 years old.
4. What Happens if You Overdose on Acnotin?
Overdosing on Acnotin can result in vitamin A toxicity with symptoms such as:
Dizziness.
Abdominal pain, headache, nausea, vomiting.
Increased intracranial pressure.
Skin irritation: redness and itching.
If overdose symptoms occur, stop taking Acnotin immediately and consult a doctor.
5. Side Effects of Acnotin 10
When taken at the standard dosage, Acnotin 10 side effects are usually mild. However, misuse or excessive dosing can cause severe adverse effects, such as:
- Dermatological: Itching, dermatitis, perionychitis, hair loss, acne flare-ups, hyperpigmentation, increased photosensitivity.
- Musculoskeletal: Joint stiffness, tendon inflammation, bone overgrowth.
- Neurological: Behavioral changes, headaches, seizures, depression.
- Sensory Impairments: Hearing loss, visual field disturbances, night blindness, keratitis, cataracts.
- Gastrointestinal: Colitis, enteritis, gastrointestinal bleeding.
- Hepatic: Hepatitis, temporary liver enzyme elevation.
- Respiratory: Bronchospasm.
- Hematological: Reduced white and red blood cell counts, abnormal platelet levels.
6. Contraindications for Acnotin 10
Acnotin 10 should not be used in the following cases:
- Allergy to isotretinoin or any other ingredient in the medication.
- Patients with impaired liver or kidney function, hyperlipidemia, or vitamin A toxicity.
- Pregnant or breastfeeding women, or those planning to become pregnant.
7. Precautions When Using Acnotin 10
To ensure safety, consider the following precautions:
- If acne is caused by androgen hormones, avoid using progestin-containing birth control pills.
- Do not undergo facial treatments such as micro-needling or chemical peels during Acnotin therapy or for 5–6 months afterward, as they increase the risk of keloid scarring.
- Avoid waxing for hair removal during treatment to prevent dermatitis.
- Pregnant women or those planning pregnancy must not use Acnotin due to the risk of severe fetal abnormalities.
- Isotretinoin can also be excreted into breast milk, so breastfeeding mothers should not use the medication.
8. Drug Interactions with Acnotin 10
Avoid combining Acnotin with the following:
- Vitamin A: Increases the risk of vitamin A toxicity.
- Tetracycline and minocycline: May cause increased intracranial pressure, resulting in headaches, vomiting, or edema.
- Low-dose progesterone and phenytoin: Reduces Acnotin's effectiveness.
Ketoconazole: Increases corticosteroid levels in the blood.
Stop using topical products containing benzoyl peroxide, tretinoin, or sulfur before starting Acnotin therapy.
Acnotin 10 is a specialized acne medication prescribed for severe acne cases or body acne that do not respond to other treatments. To avoid unwanted side effects and complications, never use Acnotin without a doctor's prescription.
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