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Tamik drug with dihydroergotamine ingredient is made in capsule form. The drug is indicated for the treatment of migraine but requires a prescription from a doctor. However, in the process of using the drug, the patient may experience some unwanted side effects such as nausea, cramps, pain, anxiety ... Therefore, before using the drug you need to learn carefully. carefully and should consult the treating physician.
1. Mechanism of action of the drug Tamik
Tamik drug has the main ingredient including the compound dihydroergotamine.
So what disease does this compound in Tamik treat? Although the compound dihydroergotamine has a rather complex effect, it has an affinity for both alpha adrenergic and serotoninergic receptors, so it has both stimulant and inhibitory effects. In the mechanism of lowering blood pressure in the standing position, the compound dihydroergotamine selectively causes vasoconstriction of reservoir vessels such as veins and venules. This will have almost no effect on resistance vessels such as arteries and arterioles. Furthermore, dihydroergotamine increases venous tone leading to dialysis and may prevent excessive venous accumulation.
For migraine, at the beginning, Tamik drug works to compensate for the lack of serotonin in the blood plasma. Then, the drug will affect and stimulate the effect of serotonin, so it has the ability to counteract the loss of tone of the extracranial vascular system, especially the dilated carotid system. To effectively treat migraine attacks, patients also need to be prescribed dihydroergotamine injections for faster effects. In the prevention of migraine, patients should take the drug in capsule form for a long time while stabilizing the extracranial vascular system.
Tamik drug when put into the body, about 30% of the drug is absorbed. The first half takes about 10 to 20 minutes, the drug is rapidly absorbed into the body and the maximum plasma concentration is reached 1 hour after taking the drug. Dihydroergotamine is about 93% bound to plasma proteins. The apparent volume of distribution is 30 liters/kg. Systemic clearance when using the drug is about 1.5 l/min and the drug is mainly cleared by the liver.
Initially, the drug is excreted in the urine with about 1 to 3% of metabolites. The process of elimination of Dihydroergotamine compounds is mainly through the biliary tract and faeces.
2. Indications and contraindications for the use of Tamik
Tamik is indicated for the treatment or prevention of recurrent migraine and cluster headaches i.e. localized pain. In addition, the drug is also used for orthostatic circulatory disorders, primary / secondary hypotension or symptoms such as dizziness, prolonged fatigue.
Tamik is also indicated for the treatment of vasomotor headaches.
Tamik drug is contraindicated in some cases:
People with a history of hypersensitivity to the components of Tamik drug People who are prone to diseases that react to vasoconstriction such as peripheral artery disease, coronary artery disease, especially especially for those with unstable angina, sepsis, or those prone to shock, vascular surgery, or uncontrolled hypertension, or severe liver or kidney failure. Women who are pregnant or women who are breastfeeding.
3. Dosage and usage of Tamik
Tamik is made in the form of tablets. Patients can take the drug with meals. The usual dose for adults is 3mg, corresponding to 1 tablet, taken three times a day.
The dosage of Tamik above is for reference only. Therefore, if you use the drug to improve your health, you need to learn carefully and consult a doctor.
If you forget to take your medicine, use it as soon as you remember the missed dose. However, if the missed dose of Tamik is close to the next dose, you should skip the missed dose and take the next dose. You should note that you should not double the dose of Tamik, because this can cause bad symptoms affecting health.
In case of drug overdose, you need to stop using and see a doctor for timely support.
4. Unwanted side effects when using Tamik
Tamik drug can cause unwanted side effects for patients during treatment. Side effects can be divided into:
Common side effects include systemic side effects with headache, gastrointestinal related symptoms causing nausea, vomiting, and pulse related symptoms. peripheral causes leg cramps and pain.
Uncommon side effects are generally related to the whole body with dizziness, anxiety, profuse sweating, gastrointestinal related such as diarrhea, skin related such as rash and flushing, respiratory related such as dyspnoea, circulatory-related such as vasospasm, hypertension, or paresthesias, pleural fibrosis and accessory membranes suffer from prolonged treatment.
Rare systemic side effects causing myocardial infarction or cerebrovascular accident.
When experiencing unwanted side effects, the patient should stop using the drug and immediately notify the treating doctor.
5. Notes when using Tamik
Patients using Tamik drug in the treatment of migraine should note:
Dihydroergotamine ingredient in Tamik drug is like ergot alkaloid, so it can cause eye spasms, or even angina. However, these cases are quite rare, but patients need to carefully study this effect before using the drug. Patients should use the ingredient Dihydroergotamine for vasomotor migraines. However, this ingredient will not work for other types of headaches, or it will not work for other headaches. When using Tamik, patients should tell their doctor immediately if they experience signs such as: loss of sensation or pain in the tips of their toes or fingers, or muscle pain in the arms or legs, or weakness in the lower extremities. chest pain accompanied by a slow heart rate, or possibly temporary swelling or itching. Drug interactions Tamik
Tamik drug combined with vasoconstrictor drugs may cause an excessive increase in blood pressure because Tamik's ingredient is Dihydroergotamine, which has the ability to combine with vasoconstrictors and sympathomimetic drugs. Tamik with its ingredient Dihydroergotamine interacts with beta-blockers. Erectile dysfunction causes vasoconstriction and beta-blockers also cause vasoconstriction. So when combined will reduce blood flow and reduce flow to the heart. Tamik interacts with nicotine compounds, in which nicotine can cause vasoconstriction in some patients. The combination of these two drugs may increase the predisposition to ischemia. Tamik drug used together with macrolide antibiotics such as erythromycin, josamycin, ponsinomycin, triacetyloleandomycin, can make ergot toxicity increase faster than Tamik drug combined with glyceryl trinitrate, the Dihydroergotamine component will counteract the effect. vasodilatation of glyceryl trinitrate. Tamik in combination with ergot and methysergid may increase the risk of spasm of major arteries in patients. Tamik is contraindicated in combination with the ingredient Sumatriptan. In theory, this compound could increase the risk of coronary artery spasm. Therefore, using these two ingredients should be about 24 hours apart. Vinmec International General Hospital is one of the hospitals that not only ensures professional quality with a team of leading doctors, modern equipment and technology, but also stands out for its examination and consulting services. and comprehensive, professional medical treatment; civilized, polite, safe and sterile medical examination and treatment space.
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