What are the uses of Rosiglitazone?

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1. What is Rosiglitazone?

Rosiglitazone is a thiazolidinedione derivative for type 2 diabetes, and is available in the form of film-coated tablets. With the main ingredient in the form of Rosiglitazone maleate and excipients sufficient and includes tablets containing 2mg, 4mg, 8mg Rosiglitazone base. Rosiglitazone's mechanism of action is to restore the body's proper response to insulin, thereby lowering blood sugar levels. Limiting high blood sugar helps prevent kidney damage, blindness, and neurological problems. At the same time, the drug can also reduce the risk of stroke and heart disease.

2. Uses of the drug Rosiglitazone

Rosiglitazone is indicated for the treatment of non-insulin-dependent type 2 diabetes. With the use of Rosiglitazone in the treatment of disease, patients need to use it in combination with an appropriate diet and exercise regimen to control blood sugar well.
In case of monotherapy: indicated for patients who cannot adequately control blood sugar with diet, exercise and cannot use metformin due to contraindications or intolerance. Two-drug combination: Rosiglitazone is used in combination with metformin for patients whose glycemic control is not adequately controlled by metformin monotherapy at maximum dose. Rosiglitazone is used in combination with a sulfonylurea when sulfonylurea monotherapy does not provide adequate glucose control. In case of triple combination: Rosiglitazone can be used in combination with metformin and a sulfonylurea when the two drugs alone do not provide adequate glycemic control. Rosiglitazone improves insulin sensitivity to target cells, reduces insulin resistance, both blood insulin and HbA1C, thereby improving glycemic control. Rosiglitazone has a mechanism of action to reduce triglycerides and increase LDL and HDL. The ratio of LDL/HDL increases to a maximum in the first 2 months, then gradually decreases.

3. Dosage of Rosiglitazone

Besides understanding what Rosiglitazone is, you need to know how to use it. Rosiglitazone is taken orally, the dose is based on the patient's condition, response to treatment, and as directed by your doctor. The following are the commonly recommended doses:
For monotherapy: Initial dose is 4 mg/day, taken once or in 2 divided doses/day, morning and evening, taken with or after meals. If the response is inadequate after 8-12 weeks of treatment, the dose may be increased to 8 mg/day, orally once or in two divided doses. Effects improve gradually and reach maximum after about 8 weeks of treatment.
For combination with metformin: The initial dose of Rosiglitazone is 4mg/day, taken once or twice. If, after 8-12 weeks of treatment, the response is not satisfactory, the dose of Rosiglitazone can be increased to 8 mg/day, orally once or twice a day.
For combination with sulfonylurea: The dose of Rosiglitazone when combined is 4 mg/day, orally once or twice a day, the dose of the sulfonylurea remains the same. If the response is inadequate after 8-12 weeks of treatment, the dose of Rosiglitazone can be increased to 8 mg/day, orally once or in two divided doses. If hypoglycemia occurs, the dose of the sulfonylurea must be reduced. For Rosiglitazone in combination with metformin and a sulfonylurea: The initial dose of Rosiglitazone is 4 mg/day, orally once or twice a day. If the glycemic response is not satisfactory after 8-12 weeks of treatment, the dose of Rosiglitazone can be increased to 8 mg/day, orally once or twice daily. If hypoglycemia occurs, the dose of the sulfonylurea should be reduced.

4. Contraindications to the use of Rosiglitazone

Rosiglitazone drug is contraindicated in the following cases:
Hypersensitivity, allergy to any ingredient of the drug. Pregnant women, lactating women and children under 18 years of age. Patients with heart failure grade 3 - 4 or a history of heart failure, myocardial infarction. People with type 1 diabetes or high blood sugar in other diseases.

5. Side effects when using the drug Rosiglitazone

Because it is a drug belonging to the group of hormones, hormones, long-term continuous use, most users of Rosiglitazone can experience increased blood volume leading to heart failure, weight gain and some unwanted side effects. wanted as follows:
Common: LDL-cholesterol, total cholesterol increased; dizziness, dizziness, headache, fatigue; sinusitis , inflammation of the upper respiratory tract ; edema; diarrhea; decreased hemoglobin; decreased red blood cells and white blood cells. Uncommon: Angina pectoris ; increased bilirubin; Hepatitis; vision loss; medal; hypoglycaemia in combination with a sulfonylurea.

6. Notes when using Rosiglitazone

When there are abnormal signs during the use of the drug, the patient needs to go to the hospital for examination and related tests so that the doctor can supervise, guide and advise on the use of Rosiglitazone.
Rosiglitazone should not be used in combination with insulin. Rosiglitazone may cause or worsen congestive heart failure, requiring close monitoring for signs or symptoms. Use with caution in patients with edema because it can increase plasma volume, cause fluid retention, leading to heart failure. Rosiglitazone e may also be associated with angina pectoris and myocardial infarction, so an alternative to Pioglitazone may be considered because of the similar mechanism of action and therapeutic efficacy. With caution in patients with high liver enzymes (AST or ALT); Do not initiate rosiglitazone in patients with active liver disease or ALT >2.5 times the upper limit of normal. During treatment, if ALT > 3 times the upper limit of normal, the drug must be discontinued. When starting treatment with Rosiglitazone, it is necessary to monitor and monitor the situation and signs of health, if there is any abnormality, it is necessary to immediately report to the doctor for timely treatment.
In summary, Rosiglitazone is one of the drugs in the group of hormonal and endocrine drugs and is used in the treatment of type 2 diabetes.; To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take drugs according to prescription or consult a doctor, professional pharmacist.
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