This is an automatically translated article.
Isosorbide 30mg drug has the main effect of preventing and treating angina (cardiac spasm). In addition, when combined with other drugs, it also helps to treat congestive heart failure.
1. What is Isosorbide? Isosorbide drug effects
Drug Isosorbide Dinitrate is the leading drug in the treatment of angina attacks, the drug has a quick pain relief effect, especially effective with Prinzmetal vasoconstriction angina pectoris.
The main effects of Isosorbide can include:
Prevention of angina; Treatment of myocardial infarction due to drugs helps to reduce the area of ischemia and extracorporeal; Treatment of high blood pressure; Treatment of congestive heart failure, especially left heart failure with increased peripheral resistance and pulmonary capillary pressure. Currently on the market Isosorbide is produced in the following forms:
Tablets (chew, oral, lozenge, long-acting) with the content of 5mg, 10mg, 20mg, 40mg, 60mg; Capsules (long-acting): 20mg, 40mg; Aerosol solution 1.25mg contains Glycerol, Ethanol.
Isosorbide là một trong các loại thuốc điều trị các cơn đau thắt ngực,
2. Instructions for using the drug Isosorbide
Depending on the purpose of treatment, the dose of Isosorbide will be adjusted flexibly, for example:
Prevention of angina: Take 10-20mg/time, 3-4 times/day, the drug can be used below 20-40-60mg delayed-release form to reduce the number of doses; Treatment of angina: Sublingual or chewing: Use 2.5 - 10mg/time; every 2-3 hours until the pain is gone; can be used as spray 1.25mg/time, spray 1-3 times under the tongue (do not inhale), 30 seconds apart each time; Treatment of congestive heart failure: 5-10mg sublingual or placenta, or 10-20mg/time or more, 3-4 times/day and then reduce to maintenance dose (slow-release tablets can be used); *Note:
To avoid the risk of orthostatic hypotension and headache in some patients, it is necessary to increase the dose of Isosorbide slowly and remember to sit or lie down after taking the drug; If you are taking a high dose, avoid a sudden drop; For the elderly, there are no special instructions but still need to be careful with people who are sensitive to drugs that cause hypotension; The safety and effectiveness of the drug has not been established for children, pregnant and lactating women.
3. Side effects of drugs
During the use of Isosorbide, some people may experience side effects such as:
Common side effects:
Peripheral vasodilation causing flushing of the skin (chest and face); dilation of blood vessels in the eye easily causes increased fluid secretion and glaucoma; dilation of blood vessels in the brain increases intracranial pressure and headaches; Orthostatic hypotension: often occurs in people with low blood pressure, the elderly, causing a feeling of lightheadedness, dizziness; Uncommon side effects: May cause rash, gastrointestinal disturbances, exfoliative dermatitis;
Rare side effects: In case of overdose, patients may have reactions of hypotension, tachycardia, headache like hammering, flushed face. If doses are too high, methemoglobinemia may occur due to the oxidation of Fe++ of hemoglobin to Fe+++, causing hemoglobin to not be able to carry oxygen.
Người bệnh nên thận trọng khi sử dụng Isosorbid
4. Contraindications to the drug Isosorbide
Isosorbide is contraindicated in the following cases:
Severe anemia; Low blood pressure; Cardiovascular collapse; Increased intracranial pressure, glaucoma; Allergy to organic nitrates; Right ventricular myocardial infarction; Aortic valve stenosis ; Cardiomyopathy; Constrictive pericarditis.
5. Isosorbide drug interactions
Concomitant use of Isosorbide and Sildenafil may increase the vasodilator effects of Isosorbide, potentially leading to serious adverse events such as fainting or myocardial infarction. Therefore, these two drugs should not be taken together; Isosorbide when taken with alcohol will increase vasodilation and cause severe orthostatic hypotension. When taking the drug with Disopyramide phosphate, the anti-salivation effect of Disopyramide will interfere with the solubility of Isosorbide dinitrate lozenges. The drug Isosorbide with different dosage forms has many effects such as treating angina (heart attack), congestive heart failure, hypertension,... The use of the drug should be strictly in accordance with the indications of the doctor. doctor about the dose, time of use, ... to ensure the highest therapeutic effect, reduce the risk of experiencing unwanted reactions.
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