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Treatan tablet 8mg belongs to the group of cardiovascular drugs with the main ingredient Candesartan, usually indicated for the treatment of hypertension alone or in combination with other antihypertensive drugs. How to use Treatan Tablet 8mg?
1. What is Treatan?
Treatan tablet 8mg has the main ingredient candesartan, which is a medicine to treat high blood pressure. The antihypertensive effect of Treatan tablet 8mg is due to the following mechanisms:
Direct vasodilator should reduce peripheral resistance Peripheral sympathetic tone: decrease release of noradrenalin from the adrenal medulla, nor-adrenaline increases in Stored granules inactive form Decreased release of vasopressin from the pituitary gland and decreased vascular response to vasopressors: vasopressin and noradrenaline Decreased myocardial contractility by inhibiting the opening of calcium channels in the myocardium Decreased heart rate heart due to decreased sympathetic tone Reduces ventricular hypertrophy and fibrosis Reduce aldosterone release and increases renal circulation, thus increasing glomerular filtration rate Treatan tablet 8mg is usually indicated in the following cases:
Hypertension Treatment of chronic congestive heart failure The contraindications of Treatan tablet 8mg include:
Patients with hypersensitivity to the components of Treatan tablet 8mg Patients with severe liver failure and/or cholestasis
2. Dosage of Treatan tablet 8mg
Treatan tablet 8mg can be taken with or without food. Depending on the subject and the therapeutic goal, the dosage of Treatan tablet 8mg will be different, specifically as follows:
The usual starting dose is 16 mg of candesartan once a day when used as monotherapy in patients. No volume depletion Can be used 1-2 doses/day with a total dose in the range of 8-32mg. Higher doses do not give greater efficacy Most antihypertensive effects appear within 2 weeks and peak blood pressure reduction is achieved 4-6 weeks after treatment with candesartan If used alone Candesartan does not control blood pressure can be added a diuretic Candesartan can be used in combination with other antihypertensive agents In patients with moderate hepatic impairment should consider starting low dose candesartan, no need to adjust Initial dose in patients with mild hepatic impairment For patients at risk of intravascular volume depletion (diuretic therapy, renal failure) consideration should be given to starting treatment with a lower dose of candesartan. May cause hypotension, dizziness and tachycardia, bradycardia parasympathetic stimulation. At this point, it is necessary to immediately apply supportive measures, but candesartan cannot be ruled out by hemodialysis.
3. Side effects of Treatan tablet 8mg
In some patients when using Treatan tablet 8mg may experience side effects such as:
Fever, body weakness Paresthesias, dizziness Indigestion, gastroenteritis Tachycardia, palpitations Disorders Metabolism and nutrition Muscle pain Nosebleeds Nervousness, lethargy Shortness of breath Rash, profuse sweating Hematuria Angina pectoris, myocardial infarction, angioedema
4. Be careful when using Treatan Tablet 8mg
Some general notes when using Treatan tablet 8mg include:
In patients who lose salt and fluid volume (such as diuretic therapy) may occur symptoms of hypotension when using Treatan tablet 8mg . These symptoms should be resolved prior to administration or treatment under close supervision. However, transient hypotension is not a contraindication for later treatment and treatment is not difficult once blood pressure is stable. Because of the drug's inhibitory effect on the renin-angiotensin-aldosterone enzyme system, changes in renal function should be anticipated in susceptible individuals treated with Treatan tablet 8 mg. ACE inhibitors in patients with unilateral or bilateral renal artery stenosis have been reported to increase plasma creatinine or BUN. When using Treatan tablet 8mg in pregnant women during the second and third trimesters of pregnancy can directly affect the renin-angiotensin-aldosterone system, thereby causing damage and possibly death to the fetus.
There are no clear studies on whether candesartan is excreted in human milk, but because of the strong reactions, it is best not to take the drug during this period.
Care should be taken when using Treatan tablet 8mg while driving and operating machinery because it may cause dizziness, drowsiness, neurasthenia
Caution when using candesartan with drugs that can increase blood potassium levels such as spironolactone and potassium supplements
There is an increase in plasma lithium levels during co-administration of lithium with candesartan, so careful monitoring of plasma lithium levels is required when these two drugs are co-administered.
Above is important information about Treatan Tablet 8mg, patients need to carefully read the instructions for use before using and consult a doctor to get the best treatment results.
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