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Ayvakit medicine containing the ingredient Avapritinib is clinically indicated for the treatment of gastrointestinal stromal cancers such as bowel cancer, gastric cancer, and esophageal cancer. The drug works by stopping the growth of cancer cells. Let's learn about the uses and notes when using Ayvakit through the article below.1. What is Ayvakit?
Ayvakit contains the main ingredient Avapritinib - a kinase inhibitor designed to target the active kinase structure. Avapritinib has been studied extensively to inhibit GIST-associated PDGFRA and KIT mutations. The drug is indicated in the treatment of gastrointestinal stromal cancer in adults who have metastasized or cannot undergo surgery such as stomach cancer, esophageal cancer, bowel cancer.
2. Dosage of Ayvakit
Ayvakit medicine used to treat gastrointestinal stromal cancer is made in the form of tablets, belongs to the group of prescriptions, so the dose is prescribed by the treating doctor. Patients should take the drug on an empty stomach (1 hour before meals or 2 hours after meals) for better absorption, the usual dose is 1 tablet / day.
The dose of drugs prescribed depends on the type of cancer, the patient's condition, the ability to respond to treatment as well as other gastrointestinal cancer drugs that the patient is being treated. Therefore, the patient needs to inform the treating doctor with full information about the drugs used (including prescription drugs, non-prescription drugs, drugs of medicinal origin).
Patients need to adhere to the treatment course, take the medicine regularly as prescribed by the doctor to achieve high efficiency. Patients should take their medication at the same time each day to avoid forgetting.
Absolutely do not arbitrarily increase the dose of Ayvakit or use the wrong medicine prescribed by the doctor because the condition will not only not heal quickly but also increase the risk of serious side effects.
Ayvakit medicine has the ability to be absorbed through the lungs, skin and harm an unborn baby. Therefore, the drug should not be used in the treatment of pregnant women.
3. Side effects of the drug Ayvakit
Ayvakit can cause some side effects as follows:
Drowsiness, dizziness; Fatigue, muscle weakness; Tears, swelling; Diarrhea ; Change in taste, loss of appetite, loss of appetite; Abdominal pain, stomach pain ; Vomiting, nausea; Hair loss, hair color change. Ayvakit can affect mood and thinking, so patients should immediately inform their treating doctor in case of signs of mental changes such as confusion, forgetfulness, difficulty communicating with people. people, difficulty thinking clearly, depression, agitation, personality changes.
In addition, Ayvakit can cause bleeding, bleeding with symptoms such as vision problems, severe headache, weakness on one side of the body, drowsiness... The drug affects fertility in both men and women, reducing the body's immune system. This increases the risk of infections and aggravates other infections. Patients need to inform the treating doctor in case there are signs of infection such as fever, chills, sore throat, cough...
Ayvakit is capable of causing a rash but not serious. However, the patient also needs to notify the doctor in case of a severe rash, a generalized rash.
4. Notes when using Ayvakit
Before treatment with Ayvakit, the patient should inform the treating doctor if there is a history of allergies to drugs, food - drinks and liver and kidney diseases, brain cancer, ischemic attacks. transient set, stroke.
Ayvakit makes patients susceptible to infectious diseases, so patients being treated for stomach cancer with Ayvakit should limit their exposure to pathogens, do not vaccinate during treatment when there is no directed by Doctor.
Women who are pregnant, plan to become pregnant or suspect they may become pregnant should notify their doctor as soon as possible. Before treatment, the patient needs to make sure that the patient is not pregnant because the drug harms the fetus. Contraception should be used during treatment with Ayvakit and for at least 6 weeks after the last dose of drug therapy.
There are no studies to prove the ability to be excreted into breast milk of Ayvakit, but the drug has a risk of harm to children, so absolutely do not use Ayvakit in the treatment of women who are breastfeeding.
5. Drug interactions
Ayvakit medicine can cause some of the following interactions:
Macrolide antibiotics (such as Erythromycin), Azol antifungal drugs (Itraconazole, Fluconazole), Rifamycins antibiotics (Rifabutin, Rifampin), anticonvulsants (Phenytoin), , Carbamzepine) affects the excretion of Avapritinib from the body; Grapefruit and grapefruit products increase the risk of side effects from Avapritinib, so patients should not use grapefruit during treatment with Ayvakit. Above is information about uses, dosage and precautions when using Ayvakit. To ensure safety and maximize the effectiveness of treatment, patients need to take the drug exactly as prescribed by the doctor.
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Reference source: drugs.com
