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There is quite a lot of information about Syndopa, but it is not detailed. Vinmec's article below will answer questions for readers about what is Syndopa 275? How does Syndopa 275 work?
1. What is Syndopa 275 mg?
Syndopa 275 is manufactured at Sun Pharmaceutical Industries Ltd. The drug contains 2 main ingredients: Levodopa BP 250mg and Carbidopa BP 25mg. Prepared excipients in the form of 1 tablet. Syndopa 275 mg is indicated for use in the treatment of symptoms due to idiopathic Parkinson's disease, post-encephalitis and nervous system trauma caused by toxins of carbon monoxide or Mn.
2. Effects of Syndopa 275
Syndopa 275 is used in the following cases:
Indicated in the treatment of symptoms of idiopathic Parkinson's disease, post-encephalitis and Parkinson's-like symptoms. Treatment of symptoms of vomiting, nausea with standard doses and more quickly, easy to respond. Pharmacodynamics:
Current results suggest that Parkinson's disease symptoms are associated with Dopamine deficiency. However, when using Dopamine does not cross the blood-brain barrier, so it is not effective in the treatment of Parkinson's disease. However, Levodopa, the active precursor of Dopamine, crosses the blood-brain barrier, and is converted to Dopamine in the basal ganglia or brain.
When taken orally, Levodopa is rapidly metabolized or deccarboxylated to Dopamine in extracerebral tissues. Therefore, only a small fraction of the drug is transported unchanged into the central nervous system.
Because Levodopa competes with amino acids for transport across the intestinal wall, absorption of Levodopa may be reduced in patients on a high-protein diet.
Carbidopa prevents peripheral decarboxylation of levodopa. They do not cross the blood-brain barrier and therefore have no effect on the metabolism of levodopa in the central nervous system. When Carbidopa is taken with Levodopa, it increases the amount of Levodopa transported to the brain.
Pharmacokinetics:
The drug is rapidly absorbed from the small intestine after oral administration by active transport by large amino acids. Administration of the drug with meals delays absorption and reduces peak plasma concentrations by up to 30%.
Levodopa is extensively metabolized by the enzyme dopa decarboxylase. Thus, up to 95% of the drug is destroyed and 1% of the drug reaches the central nervous system. But when levodopa is combined with carbidopa, the drug reaches the central nervous system in sufficient doses and the dose of levodopa should be reduced to 75%. During the metabolism of Levodopa by dopa-decarboxylase, monoamine oxidase and catechol methyl transferase, most of these substances are converted to epinephrine and norepinephrine, leaving only a small amount of methylate to 3-O-methyl dopa. Statistically up to 30 metabolites of Levodopa have been identified. The metabolites are excreted in the urine within 1 day.
Carbidopa component is rapidly metabolised and not completely absorbed from the gastrointestinal tract. Carbidopa does not cross the blood-brain barrier and is partly excreted in the urine as unchanged drug and metabolites.
3. Dosage and way of taking medicine
How to use:
Should take Syndopa directly with a glass of water. The medicine should not be taken with meals. Use the medicine exactly as directed by your doctor. Dosage:
Each patient will have the most appropriate dose to achieve the treatment effect. Usually 70-100mg should be taken to improve vomiting.
For the first dose should be taken 3 times a day x 1 tablet / 75mg Carbidopa per day. However, the dose can be increased by 1 tablet per day or by 1 tablet every other day, up to a maximum of 8 tablets per day. If the patient is taking Levodopa, make sure to take Syndopa at least 8 hours apart. Syndopa should be used at a dose equal to one-quarter of the Levodopa dose. For maintenance therapy, the dose will be adjusted to achieve the best treatment results but should provide a minimum of 70-100mg of Carbidopa per day. In case of need can increase 1 or 1.5 tablets / day. However, not more than 8 tablets/day.
4. Contraindications to using Syndopa 275
Do not use Syndopa 275 for people with a history of hypersensitivity or allergy to any of the ingredients in the drug. In case the patient has a history of malignant melanoma and skin lesions of unknown cause, Syndopa should not be used. In case the patient has been using antidepressant drugs of the MAO class but less than 2 weeks. In case of narrow-angle glaucoma, skin lesions, history of malignancies, ... should stop taking MAOIs for at least 2 weeks during drug treatment and apply to subjects over 18 years old.
5. Drug interactions
During the use of Syndopa, if taken together with drugs for antihypertensives, depression, Phenothiazines, Butyrophenones, ... may occur drug interactions that reduce treatment effectiveness and increase unwanted side effects. .
You should inform your doctor or pharmacist of the medicines or health foods that you are taking to minimize the occurrence of unwanted drug interactions.
6. Side effects when using Syndopa 275mg
During the use of Syndopa 275 mg, it may cause side effects to the nervous system such as:
Depression, paranoia, dystonia, psychosis, anxiety, memory loss, insomnia, fatigue. fatigue, hallucinations,...; Orthostatic hypotension ; Arrhythmia ; Nausea; Difficulty swallowing; Gastrointestinal bleeding ; Blurred eyes; Duodenal ulcer ; Rapid, rapid breathing; abnormal heart rhythm; Diarrhea, urinary retention, cloudy urine; Leukopenia Hemolytic anemia; Hair loss; Penile erection; Bleeding after menopause; Mental schizophrenia. If you experience any unusual symptoms that are suspected to be caused by the use of Syndopa. You should consult a pharmacist or treating doctor for timely and accurate treatment.
7. Be careful when using drugs
Here are the cases that should be used with caution:
Absolutely not for pregnant women; Are breastfeeding; Do not use the drug when classified by FDA during pregnancy. Above is information about Syndopa 275mg's uses, dosage and usage. All information above is for reference only. The use of the drug must be under the guidance of a qualified physician.
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