Uses of Dolo Neurobion

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1. What is Dolo Neurobion?

What is Dolo Neurobion? Dolo Neurobion contains: 50mg Diclofenac + 50mg Pyridoxine (vitamin B6) + 50mg Thiamin (vitamin B1) + 1mg vitamin B12. The B vitamins in the drug act as coenzymes, making substances necessary for metabolism. They play a role in the metabolism of central and peripheral nerve cells, maintaining the structure and function of the nervous system. At the same time, vitamins of group B also have a synergistic effect if combined with the anti-nociceptive effect of the component Diclofenac in mixed pain.
The vitamins B1, B6 and B12 are important for the metabolism of the nervous system. This combination of B vitamins promotes the regeneration of damaged nerve fibers, leading to enhanced rehabilitation and neuromuscular distribution. The combination of B vitamins and Diclofenac has been used since 1962 for the treatment of pain with a combination of nociceptive and neuropathic pain. Studies have demonstrated a significant synergistic effect between the above B vitamins and the analgesic effects of Diclofenac.
Indications to use Dolo Neurobion:
Treatment of joint pain, rheumatism; Treatment of pain associated with neuritis, neuralgia; Treatment of post-traumatic and postoperative pain; Treatment of acute pain in otolaryngology, obstetrics and gynecology and maxillofacial. Contraindications to the use of Dolo Neurobion:
People with hypersensitivity to active ingredients and excipients of the drug; Patients with a history of bronchospasm, rhinitis, asthma, urticaria after treatment with non-steroidal anti-inflammatory drugs; People with acute peptic ulcer or gastrointestinal bleeding, with a history of these diseases; Patients with acute cerebral hemorrhage or other major bleeding; Patients with severe renal impairment with creatinine clearance less than 30ml/min; Patients with severe hepatic impairment have ALT/AST levels 30 times the upper limit of normal; Patients with confirmed congestive heart failure (grade II - IV), peripheral artery disease, severe ischemic heart disease, severe cerebrovascular disease; Pregnant women; Children under 12 years old (due to the high content of Diclofenac).

2. How to use and dose Dolo Neurobion

Usage: Orally. Patients should take Dolo Neurobion tablets whole without chewing with a glass of water, preferably after meals.
Dosage:
Adults: Take 1 tablet/time x 3 times/day. The maximum recommended dose is 3 tablets/day; Elderly: No dose adjustment is required; Overweight: No dose adjustment is required; Patients with mild to moderate renal or hepatic impairment: No dose adjustment is required; Children under 12 years: Contraindicated. The duration of treatment for acute mixed pain is 3 - 10 days. It is recommended to treat for as short a time as possible. Patients with persistent or chronic mixed pain may be treated for a longer period depending on the physician's judgment.
Overdose: There have been no reports of overdose with thiamin or vitamin B12. Long-term use of high doses of pyridoxine can lead to sensory neuropathy and syndromes of sensory neuropathy. These symptoms will improve gradually when treatment is stopped and then full recovery is possible.
In case patients taking Dolo Neurobion have acute Diclofenac poisoning, symptomatic and supportive treatment should be given. The treatment measures applied are gastric lavage and activated charcoal. Supportive measures should be used to avoid the risk of renal failure, hypotension, convulsions, respiratory depression and gastrointestinal irritation. At the same time, it is necessary to actively monitor the patient for timely treatment.
Missed dose: If you forget to take a dose of Dolo Neurobion, the patient should take it as soon as possible. If it is almost time for your next dose, skip the missed dose and take your next dose as scheduled.

3. Dolo Neurobion side effects

When using Dolo Neurobion, patients may experience some side effects such as:
Uncommon: gingivitis, stomatitis, exacerbation of ulcerative colitis or Crohn's disease, glossitis, esophageal damage, constipation; Rare: Hypersensitivity reactions (edema, anaphylaxis, hypotension), insomnia, disorientation, psychomotor excitability, visual disturbances, memory disturbances, sensitivity disturbances, paresthesia , tinnitus, peptic ulcer, gastrointestinal bleeding, gastrointestinal perforation, taste disturbance, hematuria, acute renal failure, proteinuria; Very rare: Leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia, hemolytic anemia, vesicular rash, eczema, Stevens-Johnson syndrome, erythema multiforme, exfoliative dermatitis scabs, toxic epidermal necrolysis, alopecia, purpura, photosensitivity reactions; Frequency not known: Hypersensitivity reactions (tachycardia, sweating, itchy skin, urticaria), confusion, dizziness, headache, fatigue, fluid retention, hypertension, edema, stroke, myocardial infarction (especially in people taking high doses of Diclofenac over 100mg/day for a long time), abdominal pain, nausea, vomiting, dyspepsia, flatulence, diarrhea, anorexia, ischemic colitis localized, hepatocellular damage, increased levels of liver enzymes (ALT, AST), hepatitis, chromatin (reddish urine, appearing in the first 8 hours after taking the drug, usually resolved within 48 hours) . When experiencing side effects of Dolo Neurobion, patients should stop taking the drug and immediately notify the doctor or go to the nearest hospital for timely diagnosis and treatment.

4. Be careful when using Dolo Neurobion

Some notes patients need to remember before and while taking Dolo Neurobion:
During treatment with Diclofenac, patients may have ulcers, bleeding, perforation of the stomach - intestines without warning signs. This risk may be increased in the elderly, people taking the drug in higher doses, or for longer periods of time. Particular caution should be exercised when Dolo Neurobion is used concurrently with drugs that increase the risk of ulceration or bleeding, such as corticosteroids, anticoagulants; In people with cardiovascular disease, Diclofenac can lead to fluid retention or edema. Diclofenac treatment, especially at doses above 100 mg/day and long-term, may be associated with an increased risk of arterial thrombosis (myocardial infarction, stroke). Special monitoring is recommended in patients with cardiovascular risk factors (hyperlipidemia, diabetes, smoking, hypertension), only using Dolo Neurobion after careful consideration; In dehydrated patients, the diclofenac component increases the risk of nephrotoxicity. Therefore, dehydration should be avoided in patients being treated with Dolo Neurobion. Special caution is recommended in patients with mild or moderate renal impairment; Dolo Neurobion should be used with caution in patients with mild or moderate hepatic impairment; Serious skin reactions may occur, especially when starting treatment with Dolo Neurobion. Therefore, Diclofenac should only be used in patients with acute intermittent porphyria or systemic lupus erythematosus after careful consideration of the benefits and risks; Long-term use of pyridoxine (6-12 months) in moderate doses may lead to an increased risk of neuropathy. Therefore, the patient's health should be monitored regularly when taking long-term drugs; Dolo Neurobion contains lactose, so it is not recommended for use in patients with galactose intolerance, glucose-galactose malabsorption or lapp lactase deficiency; Side effects such as dizziness, fatigue and visual disturbances may occur after taking Dolo Neurobion. Therefore, if affected, the patient should not drive or operate machinery; Use of Diclofenac can impair fertility in women, so it is not recommended for women who are trying to become pregnant, have difficulty conceiving or women are being tested for infertility; Diclofenac can cause disease in the embryo, so Dolo Neurobion should not be used in pregnant women; Dolo Neurobion should only be used in nursing women if treatment is needed, has been reviewed and approved by your doctor.

5. Dolo Neurobion drug interactions

Some drug interactions of Dolo Neurobion include:
The effect of L-dopa may be reduced when used concurrently with pyridoxine; Pyridoxine antagonists such as cycloserin, penicillamine, isoniazid, hydralazine may reduce the effectiveness of pyridoxine; Long-term use of loop diuretics (such as furosemide) can accelerate the elimination rate, reducing thiamine levels; Concomitant use of Dolo Neurobion with glucocorticoids, other non-steroidal anti-inflammatory drugs, serotonin reuptake inhibitors or platelet aggregation inhibitors,... may increase the risk of ulcers, gastrointestinal bleeding - intestinal ; Diclofenac may increase the effectiveness of medicines that inhibit platelet aggregation, anticoagulants (such as warfarin); Diclofenac may increase serum concentrations of phenytoin, lithium, digoxin, potassium-sparing diuretics or methotrexate, etc.; Diclofenac may increase the toxicity of cyclosporin to the kidneys; Diclofenac may decrease the effectiveness of antihypertensives or diuretics; Drugs containing probenecid or sulfinpyrazone may prolong the elimination of Diclofenac. In the process of using Dolo Neurobion, patients need to strictly follow all instructions and instructions of the doctor. Patients must not arbitrarily change the dose of the drug (increase or decrease the dose) without permission to avoid adverse health events, even life.
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