Uses of Asparlas

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1. What is Asparlas?

All cells in the body need the amino acid asparagin to survive. Normal white blood cells can make asparagin on their own, but cancer white blood cells cannot. Casparaginase Pegol-Mknl is an enzyme that accelerates the breakdown of asparagin in the blood into aspartic acid and ammonia. This reduces the level of asparagin in the body. Without asparagin available in the body, cancer cells die. The main active ingredient of Asparlas is Calaspargase Pegol-Mknl. What are the uses of Asparlas? Asparlas is indicated for use as part of a multi-agent chemotherapy regimen for the treatment of acute lymphoblastic leukemia in subjects 1 month to 21 years of age.

2. How to take Asparlas

Asparlas is used intravenously. The dosage of Asparlas is prescribed based on the patient's weight and how often the patient receives the drug will depend on the doctor's treatment plan. Asparlas is often used in combination with other medicines. The recommended dose of Asparlas is: 2,500 units/m2 IV infrequently, every 21 days.

3. Possible side effects of Asparlas

There are several steps patients can take to manage Asparlas side effects. Talk to your doctor to help you decide what would be best for your condition. The following are some of the most common or important Asparlas side effects:
3.1. Allergy to Asparlas In some cases, patients may be allergic to Asparlas. Signs of an allergic reaction to Asparlas may include: shortness of breath or difficulty breathing, chest pain, rash, flushing, itching, swelling at the injection site, or a drop in blood pressure. If the patient notices any changes in how he or she feels during the Asparlas infusion, let the nurse know right away.
3.2. Hepatotoxicity of Asparlas Asparlas can cause liver toxicity, which your doctor can monitor using blood tests called liver function tests. Notify the doctor immediately if the patient notices yellow skin or eyes, dark or brown urine, pain in the abdomen... these could be signs of liver toxicity.
3.3. Less common but important Asparlas side effects Pancreatitis: Asparlas can cause pancreatitis, which may require blood tests to check how well the patient's pancreas is working during use. Asparlas drug. Tell the doctor the date when the patient has signs of abdominal pain, nausea, or vomiting. Blood clots: Asparlas may increase the risk of blood clots forming. These blood clots can occur anywhere on the body. Symptoms of a blood clot may include a severe headache, swelling in an arm or leg, chest pain or difficulty breathing, or other symptoms. If the patient experiences any unusual symptoms, contact medical personnel or go to the emergency room. Bleeding: Asparlas may affect normal blood clotting and may cause excessive bleeding. The patient's blood clotting ability should be monitored during and after treatment. Go to the emergency room immediately if the patient has uncontrolled bleeding, blood in the urine, black or bloody stools, nosebleeds, or bleeding elsewhere. 3.4. Effects of Asparlas on Reproductive Function Exposure of the fetus to Asparlas can cause birth defects, so the patient should not become pregnant or father a child while taking Asparlas. Effective birth control is necessary during Asparlas treatment and for at least 3 months after Asparlas treatment. Asparlas can interact with oral contraceptives, so other methods of birth control should be used. Patients should not breast-feed during treatment with Asparlas and for 3 months after the last dose of Asparlas.

4. Notes before taking Asparlas

Before taking Asparlas, please tell your doctor about all of your medical conditions, especially:
Allergy to Casparaginase Pegol-Mknl or to any ingredient of Asparlas medicine History unusual bleeding; History of developing blood clots; liver problems; Pancreatic problems; Patients who are breast-feeding or planning to breast-feed Discuss all medications you are taking including prescription and non-prescription drugs, vitamins, and herbal supplements before taking Asparlas. Asparlas is an injectable medication that is injected directly into a patient's vein by a healthcare professional to treat an illness. To ensure effective treatment, users need to strictly follow the instructions of medical staff.
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Reference source: oncolink.org