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Question
Hello doctor,
I tested Pepsinogen I: 90 and I/II is greater than 20, much higher than the standard. So the doctor asked me if my Pepsinogen I and I/II are high? When there are signs of need to defecate, I can't hold back for more than 5 minutes, which is very frustrating. What disease is it a symptom of? Is there any treatment, doctor? Thank you.
Anonymous customer
Answer
Answered by Doctor Dao Minh Phuong - Department of Medical Examination & Internal Medicine Vinmec Times City International Hospital.
Hello,
With the question “Is Pepsinogen I and I/II high? ", the doctor would like to answer as follows:
Pepsinogen is an enzyme secreted by the cells of the stomach lining. The normal value of Pepsinogen I is greater than 70 ng/ml; pepsinogen II greater than 7.5 ng/ml; Pepsinogen I/II greater than 3 ng/ml. When the gastric mucosa is atrophied, intestinal metaplasia or cancer, Pepsinogen I will decrease and the ratio Pepsinogen I / II will also decrease. However, this test in early gastric cancer diagnosis only has sensitivity and specificity of 77%, 73%, respectively.
In your case, because Pepsinogen I: 90 and I/II is greater than 20; values are in the normal range, so it is less likely to think of atrophic gastritis or intestinal metaplasia or cancer. However, because the specificity and sensitivity of this test are not high, to confirm that you do not have these problems, you should still use another imaging test such as gastroscopy. When there are signs of bowel movements, can not hold back for more than 5 minutes, you should go to the medical facility for examination as soon as possible.
If you still have questions about high Pepsinogen I and I/II, you can go to the hospital of Vinmec Health System for further examination and advice. Thank you for trusting and sending questions to Vinmec. Wish you a lot of health.
Best regards!
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