This is an automatically translated article.
Advate is often recommended to be used to treat bleeding in patients with hemolytic disease A. Patients using Advate should carefully read the instructions for use and strictly follow the instructions given by the doctor. provided to ensure high treatment effectiveness.
1. Uses of Advate
Advate drug whose main ingredient is Octocog alfa (recombinant human coagulation factor VIII (rFVIII)) 500 IU. To be effective in the treatment and prevention of bleeding in patients with hemolytic disease A (congenital factor VIII deficiency), Advate temporarily elevates the level of factor VIII in the blood to aid in blood clotting. .
In addition, the drug is also used to control bleeding associated with surgery or dentistry in people with hemophilia. Also, Advate helps prevent joint damage in people 16 years of age and older with severe hemophilia A.
On the other hand, Advate is contraindicated in patients with von Willebrand disease.
2. Dosage and how to use Advate
2.1. How to use Patients using Advate should strictly follow the doctor's prescription. Absolutely do not exceed the dose or prolong the time of use than recommended.
Advate is injected into a vein through an IV. In the case of self-injection at home, the doctor will instruct the patient on how to use the IV at home. Here are the steps to administer Advate injection:
Patients need to wash their hands before injecting to avoid infection. Gently swirl the cap to open the medicine and completely dissolve the diluent with the medicine. Do not shake the vial. After mixing the Advate powder and diluent, leave the mixture at room temperature and use within 3 hours. Do not put the mixed medicine in the refrigerator. 2.2. Dosage Calculation of the required dose of factor VIII is based on experimental results showing that 1 factor VIII per kg of body weight increases plasma factor VIII activity by 2 IU/dl. The required dose is determined by the following formula:
Units needed (IU) = body weight (kg) x desired factor VIII gain (%) x 0.5
In case of hemorrhagic events In the following, factor VIII activity should not fall below the given plasma activity level (as % of normal or IU/dl) for the respective period.
Many patients wonder, what to do if you accidentally forget a dose of Advate? In fact, Advate is used as needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.
In case of drug overdose, the patient should notify the doctor for advice and timely handling measures.
3. Advate side effects
It has been recorded that patients during treatment with Advate have encountered some unwanted side effects. Patients should stop using Advate immediately if the following unusual signs appear: chest tightness, bleeding that does not stop at the injection site, nausea, vomiting, diarrhea, headache, dizziness, joint pain, rash, sore throat, cough, stuffy nose;...
Listed above are not all side effects of Advate. Therefore, during the course of taking the drug, if you experience any unusual symptoms, the patient should also inform the doctor.
4. Use Advate safely
Before prescribing the drug, the doctor will take the patient's history of severe allergic reaction to antihemophilic factor. During treatment with Advate, you may need frequent blood tests. Use this medicine with caution in patients with heart disease. Pregnant or nursing women should consult their doctor before taking Advate. Always store Advate and diluent at room temperature for up to 6 months, not exceeding the expiration date. In short, Advate is a prescription drug, and patients should absolutely not abuse the drug for too long for a long time. This does not make the patient's condition better, but also increases the risk of unwanted effects.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
