Uses of Vilazodone

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1. What is major depression?

Major depressive disorder (MDD) consists of one or more episodes, where a major depressive episode includes a prominent and persistent episode (every day for at least 2 weeks) of depressed mood or frustration that interferes with activities of daily living and includes at least 5 of the following 9 symptoms:
Depressed mood. Loss of interest in normal activities. Significant change in weight and/or appetite. Drowsiness or insomnia. Mentally irritable or retarded. Increased fatigue. Feelings of guilt or worthlessness. Decreased ability to concentrate or slow down thinking. Intent to commit suicide.

2. What is Vilazodone?

Vilazodone drug is a neurotropic drug prepared under 20, 40, 60 and 80 mg tablets, with the main ingredients including:
Active ingredient: Vilazodone (Polymorph Form IV Vilazodone hydrochloride). Excipients: Lactose monohydrate, Microcrystalline cellulose, Magnesium stearate, Colloidal silicon dioxide, Polyvinyl alcohol, Titanium dioxide, Polyethylene glycol, Talc powder, FD&C Blue, FD&C Yellow and FD&C Red just enough for 1 tablet. Pharmacodynamics: The mechanism of Vilazodone's antidepressant action is not fully understood, but is thought to be related to enhancement of CNS Serotonergic activity through selective inhibition of Serotonin reuptake. Vilazodone is also a partial agonist at 5-HT1A Serotonergic receptors, however, the experimental results of this effect on Serotonergic transmission and its role in the antidepressant effects of Vilazodone are unknown. clear.

3. What disease does Vilazodone treat?

Vilazodone is indicated for the treatment of major depressive disorder (MDD).

4. Contraindications of Vilazodone

Contraindications of Vilazodone drug in the following cases:
Hypersensitivity to any component of Vilazodone drug. History of allergy to drugs containing the active ingredient Vilazodone hydrochloride. People who are taking Monoamine Oxidase Inhibitors (MAOIs) or in the 14 days before taking Vilazodone. Pregnant women, lactating women or children. People with severe renal impairment.

5. Dosage and usage of Vilazodone

Note: Patients need to take Vilazodone with meals.
Adults
Starting dose (first 7 days): Take 10 mg/time x 1 time/day. Dose for the next 7 days: Take 20 mg/time x 1 time/day. Maintenance dose: Oral 40 mg/time x 1 time/day

6. Precautions when using Vilazodone

Treatment with Vilazodone drug with high dose or prolonged, can cause side effects such as:
Cardiovascular: Palpitations c, ventricular extrasystoles. Digestive disorders: Decreased appetite, diarrhea, nausea, dry mouth, vomiting, dyspepsia, flatulence, gastroenteritis Nervous: Sedation, migraine, developmental disorders, dizziness , paresthesia, tremor. Psychiatric: Insomnia, nightmares, fatigue, restlessness, decreased libido, panic attacks, mania. Vision: Dry eyes, blurred vision, cataracts. Genitourinary: Erectile dysfunction, delayed ejaculation. Urinary: Hematuria. Skin and soft tissue: Night sweats, skin rash, angioedema, urticaria, pruritus. Body as a whole: Anaphylaxis, multi-organ failure. Should stop the drug when detecting the above symptoms or other abnormalities after taking Vilazodone and promptly notify the treating doctor or go to the nearest hospital for timely treatment.
Note the use of Vilazodone drug in the following subjects:
For patients with major depressive disorder (MDD), some cases may experience more severe depression and/or new ideas and behaviors. suicidal behavior or unusual changes in behavior despite treatment with Vilazodone. Therefore, all patients being treated with Vilazodone should be closely and appropriately monitored for timely clinical deterioration, suicidality, and unusual changes in behavior. especially during the first few months of drug therapy, or at times when the dose is changed, or the dose of Vilazodone is increased or decreased. Vilazodone should be used with caution in people with a history of or are suffering from Serotonin syndrome, neuroleptic malignant syndrome (NMS), convulsions, coagulopathy, bleeding abnormalities, bipolar mania. or Hypomania, hyponatremia. Pregnant women: The US Food and Drug Administration (FDA) classifies Vilazodone as Group C, a group with evidence of a risk in pregnancy. Therefore, Vilazodone is contraindicated in pregnant women. Lactation: Studies have shown that Vilazodone passes into breast milk, however its effect on breast-feeding is unknown. Therefore, the use of Vilazodone should only be considered if the potential benefit outweighs the potential risk to the child. Drivers or machine operators may experience some visual disturbances or neurological disorders after using Vilazodone, it is recommended not to use Vilazodone while working.

7. Vilazodone drug interactions

Interactions with other drugs:
Avoid combining Vilazodone with other drugs that can affect the Serotonergic neurotransmitter system such as:
MAOIs, SSRIs, SNRIs. Triptans Buspirone Tramadol Tryptophan Avoid combining Vilazodone with NSAIDs, Aspirin and Warfarin, because it can cause clotting disorders, increasing the risk of abnormal bleeding.
Above is the necessary information about the ingredients, uses, doses and side effects or notes of Vilazodone. Patients and family members should carefully read the instructions on the Vilazodone package, and consult with the treating doctor before deciding to use it.
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