This is an automatically translated article.
ZT Amox drug with the main ingredient Amoxicillin is indicated for the treatment of mild respiratory infections or otitis media or sinusitis... However, when using the drug, there may be some unwanted side effects such as: diarrhea, nausea, gastritis... So before using you should learn carefully and get advice from the treating doctor.
1. Mechanism of action of the drug ZT Amox
ZT Amox medicine contains Amoxicillin which belongs to the group of oral antibiotics in combination with a beta-lactamase inhibitor, potassium, clavulanate. Amoxicillin is similar to ampicillin which is derived from the basic penicillin nuclei, and 6-aminoopenicillanic acid. Clavulanic acid in ZT Amox is formed by the fermentation of treptomyces clauvuligéu - a beta-lactamase group structurally related to penicillins and capable of inactivating many betalactamases by blocking the active sites. of this enzyme. Clavulanic acid is primarily active against plasmid activities mediated by beta-lactamases that are often responsible for resistance to penicillins and cephalosporins.
Clavulanic acid does not affect the pharmacokinetics of ZT Amox. When Amoxicillin and Potassium Clavulanate compounds are taken into the body, they will be absorbed in the gastrointestinal tract. The oral bioavailability of the ingredients in ZT Amox is 90% Amoxicillin and 75% Clavulanate, respectively. These compounds act unaffected by food. And drug concentrations when entering the body peak in serum about 1 hour after oral administration. Amoxicillin concentrations of ZT Amox also reached the same peak levels as when using Amoxicillin alone at the same dose. When increasing the oral dose of the Amoxicillin component, gastrointestinal absorption may decrease and serum concentrations and AUC may increase linearly with increasing dose. Both components of ZT Amox have a low ability to bind to serum proteins.
When ZT Amox drug enters the body, it will be diffused well in the fluid in the middle ear, peritoneal fluid, pleural fluid, urine... Especially Amoxicillin has good diffusing ability in most tissues and body fluids. body, but excluding cerebrospinal fluid. When the meninges are inflamed, the penetration of Amoxicillin and Clavulanic acid is increased. According to research, about 10% of Amoxicillin and 50% of Clavulanic acid are metabolised in the liver.
ZT Amox is eliminated mainly by the kidneys. Following oral administration, patients with normal renal function have a half-life of approximately 1.3 hours for Amoxicillin and 1 hour for Clavulanic acid.
2. Indications and contraindications for using ZT Amox
ZT Amox medicine is indicated for use in the following cases:
Mild respiratory tract infections caused by strains such as: H. Influenzae and M.catarrhalis producing beta - lactamase. Otitis media caused by strains such as: H. Influenzae and M.catarrhalis that also produce beta lactamase Sinusitis caused by strains of H. Influenzae and M. catarrhalis that produce beta lactamase strains of S. aureus, E.coli and Klebsiella spp. simultaneously produce beta - lactamase. Urinary tract infections for strains such as: E.coli and Klebsiella spp and Enterobacter spp produce beta - lactamase. ZT Amox drug may be contraindicated in some cases such as: patients with a history of allergy to components of the drug containing penicillin, or cases of cross-reactivity with other beta-lactam antibiotics, or people patients with a history of jaundice, impaired liver function when using amoxicillin or Clavulanic acid or penicillin.
3. Dosage and how to use ZT Amox
ZT Amox medicine is in the form of powder packs. Before using the drug, it is necessary to dilute half of the vial with filtered water and then shake vigorously to dissolve the drug into a homogeneous solution. In 5ml of diluted ZT Amox medicine contains 200mg of amoxicillin and 28.5mg of Clavulanic acid. The drug should be used within 14 days of opening and dilution. To minimize the possibility of drug intolerance through the gastrointestinal tract, you should take the drug immediately before a meal.
For adults, if the infection is mild to moderate, use a dose of 25/3.6mg/kg/day every 12 hours. For severe infections, use 45/6.4 mg/kg/day every 12 hours.
For children, between the ages of 2 months and 2 years with mild or moderate infections, the dose should be calculated according to body weight. The daily dose should be divided equally every 12 hours. As for children from 2 years old to 6 years old, the average infection dose is 25/3.6mg/kg/day divided into 2 times and 5ml each time 12 hours apart. In case this child has a severe infection, the dose is 45/6.4mg/kg/day and divided into 2 doses of 10ml each time, taking 12 hours apart.
For children with severe infections when the body weight is over 8kg, use ZT Amox 400mg/57mg dose. At half dose, 200/mg28.5mg is not recommended for children under 2 months of age. Because the child's kidney organization is not yet complete.
In case the patient has a creatinine clearance greater than 30ml/min, there is no need to change the dose. But conversely, patients with creatinine clearance less than 30ml/min are not recommended to use this drug.
The dosage of ZT Amox above is for reference only. Therefore, if you use the drug to improve your health, you need to learn carefully and consult a doctor.
If you forget to take your medicine, use it as soon as you remember. However, if the missed dose of ZT Amox is close to your next dose, skip the missed dose and take the next dose. Note that do not use double the dose of ZT Amox, because this can cause bad symptoms affecting health.
In case of drug overdose, the drug will not help improve the symptoms of the disease immediately. Instead, it can cause poisoning or serious side effects. If you suspect you have overdosed, call your doctor or go to a medical facility right away.
4. Unwanted side effects of ZT Amox medicine
When using ZT Amox medicine may cause some unwanted side effects with an indefinite frequency
Effects on the gastrointestinal tract causing symptoms of diarrhea, nausea, gastritis, dyspepsia ,stomatitis, enteritis, hemorrhage and pseudomembranous colitis. Causes hypersensitivity reactions such as skin rash, urticaria, hypersensitivity to drug components, angioedema, Stevens Johns syndrome, exfoliative dermatitis... Liver reaction causes a moderate increase in AST levels. or ALT in patients treated with penicillin-containing antibiotics. Or can cause liver dysfunction with symptoms of increased serum transaminases, serum bilirubin... Causes interstitial nephritis and hematuria Causes anemia, thrombocytopenia, thrombocytopenia, and leukopenia eosinophils, leukopenia and agranulocytosis.... Increased state of confusion, anxiety, drowsiness or insomnia... In case of unwanted side effects when using the drug before meals When eating, antihistamines can be used to control or if necessary, systemic corticosteroids can be used. In addition, the patient needs to stop using the drug and see a doctor for a timely support plan.
ZT Amox may interact with probenecid to reduce the renal tubular secretion of amoxicillin. Therefore, the simultaneous use of these two components may lead to increased and prolonged blood levels of amoxicillin. Or ZT Amox pills can also reduce the effectiveness of oral contraceptives, so you need to pay attention to this when using the drug.
Hopefully with the sharing about the use of Zt amox medicine, it will help to better understand how to use the drug to bring good effects to health.
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