Uses of Tazobactam

Tazobactam is a beta lactamase inhibitor that is used together with antibiotics such as piperacillin and ceftolozane to prevent their breakdown, increasing the therapeutic effect. The following article provides you with some information about the uses and precautions when using Tazobactam.

Tazobactam is a penicillanic acid sulfone derivative, a beta-lactamase inhibitor with antibacterial activity. Tazobactam contains a beta-lactam ring and irreversibly binds to beta-lactamase at or near its active site. This protects the beta-lactam antibiotics from beta-lactamase catalysis. This medicine is used together with beta-lactamase-sensitive penicillins to treat infections caused by beta-lactamase-producing organisms.
Tazobactam is combined with antibiotics such as Piperacillin and Ceftolozane in the treatment of a wide variety of bacterial infections.
Tazobactam itself has little antibacterial activity and for this reason is not usually used alone.
Piperacillin/Tazobactam was approved by the FDA in 1994, and Ceftolozane/Tazobactam was approved by the FDA in 2014, providing a broader range of antibacterial properties for gram-negative infections. In June 2019, Ceftolozane/Tazobactam was approved by the FDA for the treatment of hospital-acquired pneumonia and ventilator-associated bacterial pneumonia, which are important causes of morbidity and mortality in hospitalized patient.

Tazobactam used in combination with Piperacillin or Ceftolozane helps to extend the antibacterial spectrum of Piperacillin. As with any other antibiotic, Tazobactam should only be used for infections with proven or suspected susceptibility to antibiotics containing Tazobactam.
Tazobactam/Piperacillin
When combined with Piperacillin, it is used to treat a variety of infections, including infections caused by aerobic and anaerobic gram-positive and gram-negative bacteria. Indications for treatment with Piperacillin/Tazobactam for infections caused by susceptible strains of bacteria such as bacteremia, hospital-acquired pneumonia, obstetric and gynecological infections...
Tazobactam/Cefolozane
Tazobactam is used in combination with Ceftolozane in the treatment of infections caused by susceptible strains of bacteria in adult and pediatric patients:
Complicated intra-abdominal infections, used in combination with metronidazole. Complicated urinary tract infections, including pyelonephritis. Hospital-acquired bacterial pneumonia, ventilator-associated bacterial pneumonia.

Symptoms that may be encountered with an overdose of Piperacillin / Tazobactam such as nausea, vomiting and diarrhea. Neuromuscular excitability or convulsions may also occur with high dose intravenous piperacillin/tazobactam or in patients with renal impairment.
Currently there is no specific antidote for Piperacillin/Tazobactam. Treatment in case of overdose of Piperacillin/Tazobactam is mainly symptomatic supportive treatment. Anticonvulsants may be indicated in the presence of neuromuscular excitability or convulsions.
Similar supportive treatment measures are also taken when overdose of Ceftolozane/Tazobactam. Hemodialysis can be used to remove drugs from the circulation.

Renal toxicity note: Life-threatening nephrotoxicity has been reported in critically ill patients treated with Piperacillin/Tazobactam. Using alternative antibiotics, monitoring of renal function should be applied in critically ill patients. Pregnancy: Research has shown that Tazobactam has been found to cross the placenta in rats. Studies in rats have shown that Tazobactam has no teratogenic effects at doses 6-14 times the maximum recommended human dose. There are currently no data on the use of Tazobactam in humans. Take the medicine only under the direction of your doctor. Lactation: There are no data on the presence of Tazobactam in breast milk and no data on the effects of Tazobactam on the infant. The benefits and risks of use in lactating women should be assessed. Small concentrations of Piperacillin/Tazobactam have been found in breast milk and may lead to hypersensitivity in the nursing infant. In some cases, breastfeeding may have to be stopped while taking Piperacillin/Tazobactam. Tazobactam is a beta-lactamase inhibitor with antibacterial activity. Tazobactam is used in combination with Piperacillin or Ceftolozane to help expand the antibacterial spectrum of these antibiotics, helping to treat infections caused by beta-lactamase producing bacteria. To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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