Uses of Prograf 1mg

Prograf 1mg drug has the main ingredient Tacrolimus . The drug works to prevent transplant rejection in patients with kidney, liver or heart transplant...
Prograf is made in capsule form and packed in a box of 5 blisters x 10 tablets. The drug is manufactured by Astellas Ireland Co.,Ltd., Ireland.
In addition to the main ingredient is Tacrolimus 1mg, the drug also contains excipients just enough for 1 tablet.
The effect of the active ingredient Tacrolimus
This active ingredient has an inhibitory effect on Calcineurin and has very strong immunosuppressive activity. Mechanism of action: The drug inhibits the formation of cytotoxic lymphocytes (the main cause of rejection). At the same time, the effect blocks the activation of T cells, the activation of B cells, and other lymphocytes.

2.1. What are the uses of Prograf 1mg? Prograf 1mg is prescribed by doctors in the following cases:
Indicated to prevent transplant rejection in patients with kidney, liver or heart transplants. Resistance to other immunosuppressive agents. 2.2. Contraindications Prograf 1mg is not recommended for use in patients with a history of allergy to one or any of the ingredients in the drug, including excipients.

3.1. How to use Patients need to use Prograf 1mg orally. Accordingly, the patient should take the medicine with a full glass of water. You can drink it in the morning or at night.
Patients should take the drug on an empty stomach, at least 1 hour before meals or 2-3 hours after meals for the best absorption of Prograf 1mg.
3.2. Dosage According to Prograf 1mg is used according to the doctor's prescription or the patient can refer to the dose divided into 2 times per day.
Adults: Dosage is 0.1 - 0.2 mg/kg/day. Children: Dosage is 0.3/kg/day. Usually, the doctor will prescribe the patient to reduce the dose of the drug after the patient has had a transplant.

Missed dose: If during the course of taking the medicine, the patient forgets to take the dose, take the dose as soon as he remembers. If it is too long and it is time for your next dose, skip the missed dose and take a new dose of Prograf 1mg on schedule. Absolutely do not double the dose of Prograf 1mg than prescribed.
Overdose: When using an overdose of Prograf 1mg, the patient may experience symptoms such as: nausea, vomiting, infection, tremor, urticaria, rash, increased blood urea nitrogen, coma, increased serum creatinine and aminotransferase levels.
Therefore, when using an overdose of the drug and serious side effects appear, it is necessary to stop using it immediately and notify the doctor. In urgent cases, it is necessary to go to medical centers soon for examination and treatment.

During the use of Prograf 1mg, patients may experience some side effects with the following frequency:
Very common side effects: Hyperglycemia, diabetes mellitus, headache, insomnia , tremor, increased blood pressure, nausea, kidney failure, diarrhea. Common side effects: Increased alkaline phosphatase in the blood, weight gain, liver enzyme abnormalities, asthenia, renal tubular necrosis, pain in limbs, muscle spasms, joint pain, loss, increased sweating, yellow cholestatic skin, cholangitis, abdominal distention, constipation, abdominal pain,... Uncommon side effects: Coagulation, leukopenia, hypoglycemia, psychosis, dehydration Rare side effects : Decreased blood prothrombin, blindness, neural deafness, increased tone. Very rare side effects: Hearing loss, myasthenia gravis, bile duct stenosis, liver failure,... In addition, patients may also experience side effects such as optic nerve disease, hemolytic anemia, .. If in the process of using the drug, the patient encounters any side effects, they should stop using it immediately and notify the doctor for timely treatment.

In order to avoid drug interactions, caution should be exercised when co-administering the following drugs:
Cyp3A4 inhibitors or inducers: Because of the effect on tacrolimus metabolism.
Substances that increase the concentration of Tacrolimus in the blood:
Antifungal drugs: Ketoconazole, Isavuconazole, Fluconazole,... Grapefruit juice. Omeprazole, Nefazodone, Clarithromycin,... Active ingredient Tacrolimus can increase the concentration of Phenytoin in the blood, at the same time reduce the clearance, increase the half-life of Phenazone and Pentobarbital,... Therefore, to ensure To ensure safety and improve the effectiveness of drug use, patients need to inform their doctors about all medicines, health foods, functional foods being used and other diseases they are suffering from. The doctor considers and prescribes the appropriate medication.

During the use of Prograf 1mg, patients should pay attention to the following issues:
Pregnant women: Many cases of miscarriage, premature birth, increased risk of bleeding in newborns have been reported. reported when the patient used Prograf 1mg. Therefore, pregnant women should not use this medicine. If it is necessary to use it, strictly follow the instructions of the doctor. Lactation: Prograf 1mg may be excreted in breast milk. Therefore, to rule out adverse effects on the infant, nursing mothers should not use this drug. People who drive and operate machines: Prograf 1mg may cause visual and neurological disturbances,... thereby affecting the ability to drive, as well as operate machines. Therefore, extreme caution should be exercised when using this object. Store Prograf 1mg in a cool, dry place, the temperature is below 30 degrees Celsius, avoid direct light. Keep medicine out of reach of children and pets. Do not use the medicine after the expiration date.
In short, the drug Prograf 1mg has the main ingredient Tacrolimus. The drug is effective in preventing transplant rejection in patients with kidney, liver or heart transplants. Patients need to take the drug exactly as directed by the doctor to achieve high efficiency and minimize unwanted side effects.
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