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Drug Phabalysin 600 is used to help thin mucus and detoxify paracetamol in overdose, helping to reduce liver damage. To use the drug effectively and safely, you should note a few things and refer to the article below.
1. Uses of Phabalysin 600
The main ingredient of each package of Phabalysin 600 is Acetylcysteine 600mg and excipients just enough. Acetylcysteine is an expectorant. The drug acts on mucus by severing disulfur bridges of glycoproteins, thereby breaking up sputum into thin fragments that are easier to remove through the cough reflex.
After taking the drug, it is rapidly absorbed from the gastrointestinal tract and the liver is the organ that performs metabolism, then participates in the sulfhydryl - disulfide reaction to help thin mucus.
The uses of Phabalysin 600 are as follows:
Acetylcysteine is a N - acetyl derivative of L - cysteine, this is a natural amino - acid. Acetylcysteine is used as a mucolytic agent and an antidote to paracetamol overdose. The drug reduces the viscosity of sputum in the lungs and thereby facilitates the expulsion of sputum by cough reflex, drainage or other mechanical means. Acetylcysteine used to protect the liver from paracetamol overdose reduces the risk of toxicity, by maintaining or restoring hepatic glutathione levels. This is a substance required to inactivate the intermediate metabolite of paracetamol which can be toxic to the liver. In case of paracetamol overdose, when taking Acetylcysteine, it will be converted to cysteine, stimulating the liver to synthesize glutathione and acetylcysteine can protect the liver if treatment is started within 12 hours after taking paracetamol overdose and should be started. treatment as soon as possible.
2. Indications and contraindications of Phabalysin
Indication of Phalacosy drug in the following cases:
Mucolytic in mucus disease in diseases such as cystic fibrosis of the pancreas, respiratory diseases with thick mucus like in acute and chronic bronchitis, emphysema and bronchiectasis. Indicated to detoxify paracetamol in case of drug overdose. Phalacosy is contraindicated in the following cases:
History of asthma because when taking this drug there is a risk of a bronchospasm reaction, which can occur with all forms of drugs containing acetylcysteine. Hypersensitivity to acetylcysteine or any other ingredient of the drug. Not for use in children under 2 years of age. People who are suffering from peptic ulcer disease, because the drug damages the mucus of the gastrointestinal mucosa. Therefore, if the drug is used, it will reduce the protective effect of the gastrointestinal mucosa of the mucus, making the fluid to be attacked more strongly.
3. Usage and dosage of Phabalysin
How to use: Cut the powder pack according to the line on the medicine pack, then pour the medicine into the cup, add enough water and stir well. Take the medicine when it is dissolved and take it after meals to reduce stomach irritation.
Specific dosage is as follows:
Mucolytic in the treatment of patients with abnormal mucus secretion, diseases with thick sputum such as acute and chronic bronchitis.
For children over 14 years old and adults take one sachet/time and once a day. For children under 14 years of age: Use the appropriate dosage form. Children under 2 years old: Acetylcysteine is contraindicated. Used as an antidote in the treatment of paracetamol overdose:
The starting dose is 140 mg/kg, followed by another dose of 70 mg/kg every 4 hours and a total of 17 additional doses. Acetylcysteine is most effective when taken within 8 hours of a paracetamol overdose. After this time, the effectiveness of the drug will decrease. However, starting treatment even after 24 hours can still be beneficial, helping to reduce the risk of liver failure, liver damage. The above dose is for reference only, the specific dose may change depending on other cases as prescribed by the doctor.
4. Side effects when taking Phabalysin
Although side effects are rare, like other drugs, Phalcosy 600 also causes side effects, including:
Gastrointestinal disturbances, mucositis, tinnitus. Hypersensitivity reactions: May cause symptoms such as bronchospasm, angioedema, rash and pruritus, hypotension or sometimes hypertension may occur. When the above symptoms appear, the patient needs to go to a medical facility for treatment. Some other undesirable effects may be encountered such as: flushing, nausea and vomiting, fever, fainting, increased sweating, joint pain, blurred vision, liver dysfunction, metabolic acidosis, convulsions. convulsions, respiratory arrest or cardiac arrest. For mild side effects you can tell your doctor or pharmacist. But if you see serious side effects, you need to stop taking the medicine and notify your doctor immediately for timely treatment.
5. Notes when taking Phabalysin
To use the drug safely and effectively, you should note the following:
Before taking the drug, you need to inform your doctor about your allergy history, current medical conditions and current medications . When administered to pregnant women with paracetamol overdose with acetylcysteine is effective and it has the ability to prevent hepatotoxicity caused by pracetamol in the fetus as well as in the mother. However, with other supportive treatment, it is advisable to consult a doctor, as it has not been proven safe. The drug can also be used by women who are breastfeeding. A more diluted acetylcysteine solution should be used to reduce the likelihood of drug-induced vomiting. If drugs that cause severe vomiting should be taken into account, the risk of esophageal dilatation or gastric ulceration should be considered.
6. Phabalysin drug interactions
Drug interactions can occur when taking different drugs with Acetylcysein simultaneously. Some drugs cause interactions as follows:
With tetracyclines, should be taken at least 2 hours apart from taking Acetylcysteine. Acetylcysteine should not be used concurrently with cough suppressants, as it can cause severe mucus congestion by reducing the cough reflex to clear phlegm. Acetylcysteine may increase the vasodilator effects of nitroglycerin. This is a reducing agent, so it should not be used with substances with oxidizing properties. People with fructose, galactose intolerance or glucose-glactose malabsorption, Lapp-lactase deficiency should not take the drug.
Store the medicine in a cool dry place and avoid direct light. Do not use the medicine when it shows signs of damage such as wet, lumpy powder package and do not use after the expiry date.
Phabalysin 600 thins mucus, it can affect the natural mucus in the body. Therefore, patients should pay attention to use to avoid affecting the digestive tract. If you have any questions, you should consult your doctor or pharmacist.
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