Uses of Oxamark

Oxamark is an oral antibiotic of the penicillin group, commonly used in the case of infections caused by bacteria sensitive to Oxacillin. To learn more about the benefits and uses of the drug, please refer to the information below.

Oxamark 500 medicine has the main ingredient Oxacillin sodium equivalent to 500mg Oxacillin. The drug is in the form of hard capsules.
Oxacillin is a semi-synthetic antibiotic, belonging to the group of penicillins, this antibiotic is not inactivated by the enzyme penicillinase, which is active against gram-negative and gram-positive aerobic bacteria, especially bacteria such as staphylococcus.
Oxacillin is less active against bacteria sensitive to penicillin G and is generally not active against gram-negative bacteria. Therefore, when treating mixed systemic infections, it is necessary to use both oxacillin and high-dose penicillin G. The antibiotic oxacillin will not be effective against streptococcal infections, so it is not indicated in cases of suspected streptococcal infection.

Oxamark 500 is used in people with staphylococcal infections that are resistant to benzylpenicillin but are still sensitive to this drug as in the following cases:
In the case of infections causing osteomyelitis; Upper respiratory tract infections and lower respiratory tract infections. Skin and skin structure infections, infected burns. Infectious arthritis. Inflammation of the urinary tract. Oxamark is contraindicated in cases of severe hypersensitivity to Oxacillin or any of the penicillin group of antibiotics, or to the excipients in the drug. Should not be used in patients with a history of hypersensitivity to cephalosporin antibiotics.

3.1. How to use The drug is in the form of capsules, take this medicine with water 1 hour before meals or 2 hours after meals. It should be taken at certain intervals to maintain plasma concentrations.
3.2. Dosage Adults and children over 40 kg orally 500 mg to 1 g / time every 4-6 hours. Do not use more than 6g/day. Children: Take 12.5 to 25 mg/kg body weight/time every 6 hours. Patients with renal impairment: If patients with renal impairment have Clcr < 10 ml/min, use at the lower end of the usual dose. Overdose and treatment:
Symptoms of overdose: Causes neuromuscular hypersensitivity reactions with manifestations of agitation, hallucinations, postural disturbances, confusion, convulsions; Electrolyte imbalance with potassium or sodium salts, especially in patients with renal failure. Patients should be taken to a medical facility immediately when symptoms of overdose. Treatment is mainly symptomatic and supportive. Hemodialysis cannot rule out oxacillin.

When you use Oxamark 500 medicine, you may experience the following side effects:
Common: Mild allergic reaction; Nausea, diarrhea; rash... Uncommon: Eosinophilia, leukopenia, decreased platelet count; hives; increased liver enzymes. Rare: Anaphylactic reactions; angioedema; pseudomembranous colitis; obstructive jaundice; agranulocytosis; Interstitial nephritis and renal interstitial damage are usually reversible upon prompt discontinuation of the drug. Frequency not determined: Inflammation of the oral mucosa; Bone marrow failure; Hepatotoxicity; neurotoxic reactions, convulsions ; abnormal serum alkaline phosphatase levels; acute renal failure, hematuria, proteinuria; severe hypokalemia. When taking the drug, if you notice any unwanted effects of the drug, you should notify your doctor for timely treatment.

To prevent antibiotic resistance, you should use the right prescription, avoid using antibiotics when there is no evidence of infection, use the right dose and duration of medication. Oxacillin can cause allergic reactions like other beta-lactam drugs, therefore, before initiating treatment with this drug, the patient's history of hypersensitivity to penicillins, cephalosporins or other drugs should be carefully investigated. The drug can affect liver, kidney and blood function, so it is necessary to check liver function, kidney, blood count before and periodically during treatment if used for a long time or at high doses. Prolonged antibiotic treatment can lead to bacterial or fungal superinfection. Patients may also experience diarrhea due to Clostridium difficile infection during treatment with oral Oxacillin, especially those with a history of this bacterial infection; fungal infection of the tongue or vagina. Note to pregnant women: Oxacillin has the ability to cross the placenta. Currently, there are no studies that can confirm the safety of using oxacillin for pregnant women, so only use it when absolutely necessary and prescribed by a doctor. Lactation: Oxacillin is excreted in breast milk, but it is not known whether it will harm the infant. Therefore, it should be carefully considered when using the drug for women who are breastfeeding or it is best not to breastfeed while taking the drug. Attention when using for the elderly: Elderly people often have impaired function of organs. organs and often have multiple diseases at the same time. When prescribing to this subject, it is advisable to start at a lower dose than the general population and closely monitor liver and kidney function during treatment. Pediatric Patients: Due to incomplete renal function in pediatric patients, oxacillin may not be completely eliminated, resulting in abnormally high blood levels. Therefore, it is also necessary to monitor and regularly adjust the dose accordingly. Concomitant use of oxacillin antibiotics will reduce the effectiveness of live attenuated vaccines (e.g. cholera vaccine, tuberculosis vaccine, typhoid vaccine) and probiotics such as Lactobacillus due to drug antagonism. force studies.

Some drugs that can cause interactions include:
Interactions that reduce the effect: If taken together with Oxacillin may reduce the effectiveness of birth control pills. Anti-tetracyclines may reduce the effect of oxacillin. Increased effect: Disulfiram and probenecid may increase serum oxacillin concentrations. Concomitant administration of large doses of intravenous penicillins may potentiate the anticoagulant effect. Hopefully, with the above information about the drug, you already know its uses and what to keep in mind when using it. The drug is used under the prescription of the doctor, you follow the treatment to ensure the safest.