Precautions when using Zanedip 20mg

Zanedip 20mg drug with the main ingredient is Lercanidipine 20mg, belongs to the group of calcium blockers commonly used in the treatment of cases of essential hypertension. Knowing the basic information about the composition, uses, dosage and side effects of Zanedip 20mg drug will help patients achieve the best treatment effect.

Zanedip 20mg drug is prepared under film-coated tablets, with the main ingredients including:
Active ingredient: Lercanidipine (as Lercanidipine hydrochloride) content 20 mg. Excipients: Core tablets: Microcrystalline cellulose, Sodium starch glycolate, Lactose monohydrate, Povidone K30, Magnesium stearate. Film coated: Talc powder, Titanium dioksid (E171), Hypromellose, Macrogol 6000, Iron oxide (E172) just enough for 1 20 mg tablet. Lercanidipine hydrochloride belongs to the group of drugs called Dihydropyridine, has antihypertensive effect through antagonizing calcium and inhibiting calcium ions from transmembrane entering the myocardium and vascular smooth muscle. This directly relaxes vascular smooth muscle and reduces overall peripheral resistance. Lercanidipine has a high vascular selectivity, and the distribution of lercanidipine on the vascular wall is higher than in the vascular lumen, so there is no adverse effect on myocardial contractility. The vasodilator effect of lercanidipine occurs gradually, so it is less likely to cause acute hypotensive effects with reflex tachycardia in hypertensive patients.

Zanedip 20mg is indicated for the treatment of mild to moderate idiopathic hypertension.

Hypersensitivity to any component of the drug Zanedip 20mg. History of allergy to other medicines with active ingredient Lercanidipine hydrochloride. History of allergy to other calcium blockers. Patients with cardiovascular disease such as left ventricular outflow obstruction, untreated heart failure, unstable angina or myocardial infarction within one month. People with liver failure, severe renal failure (glomerular filtration rate GFR < 30ml/min). People who are being treated with Cyclosporin drugs, strong inhibitors of CYP3A4 or are using grapefruit juice. Pregnant or lactating women, women of childbearing potential.

4.1. It is recommended to take the drug in the morning and at least 15 minutes before meals. Use in combination with Zanedip 20mg with beta-blockers, diuretics or angiotensin-converting enzyme inhibitors if not controlled by Zanedip 20mg alone. 4.2. Dosage Adults
Usual dose: Take 1⁄2 tablets (10 mg)/time x 1 time/day. Increase dose: Take 1 tablet (20 mg) / time x 1 time / day depending on the response of the patient. Children
Zanedip 20mg is not recommended because safety has not been established. Patients with renal failure
Recommended dose: Take 1⁄2 tablets (10 mg)/time x 1 time/day. Increase dose: No more than 20 mg per day.

5.1 Side effects encountered when using Zanedip 20mg Treatment with Zanedip 20mg in high doses or for a long time, can cause side effects such as:
Uncommon: Central nervous system symptoms such as headache, dizziness. Cardiovascular symptoms such as arrhythmia, palpitations, flushing. Peripheral edema. Rare: Rash, somnolence, angina pectoris, asthenia, fatigue. Digestive disorders such as nausea, vomiting, indigestion, abdominal pain, diarrhea. Transient elevation of liver enzymes, hypotension, polyuria. Very rare: Anaphylaxis, hypersensitivity, fainting. The above symptoms usually disappear immediately after stopping using Zanedip 20mg. However, when detecting the above side effects or any other abnormalities after taking Zanedip 20mg, patients and their family should promptly notify their doctor or go to a medical facility for timely treatment. time.
5.2 Notes on the use of Zanedip 20mg in subjects Caution when using Zanedip 20mg in the elderly or children, people with a history of or are suffering from cardiovascular diseases such as sinus node insufficiency syndrome, heart failure. decreased ventricular function, angina or myocardial infarction. People with severe renal impairment or glucose/galactose malabsorption syndrome, Lapp - lactase enzyme deficiency, blood galactose. Pregnancy: Some animal studies have shown that Zanedip 20mg is not teratogenic. However, clinical studies in pregnant women are limited, so it is not recommended to use Zanedip 20mg in this population. Lactation: Studies have shown that lercanidipine can pass into breast milk because of its high lipophilicity, so Zanedip 20mg is not recommended in lactating women. Drivers or machine operators often experience some side effects such as dizziness, drowsiness, and fatigue when using Zanedip 20mg.

Do not combine Zanedip 20mg with the following drugs:
Ketoconazole Itraconazole Ritonavir Erythromycin Troleandomycin Cyclosporin Caution when combining Zanedip 20mg with the following drugs:
Terfenadine Astemizol Amiodaron Quinidin Midazolam increases the absorption of Zanedip 20mg. Interactions with Beverages
Alcohol should be avoided when using Zanedip 20mg because alcohol can increase the vasodilator effect of the drug. Do not drink grapefruit juice while using Zanedip 20mg. Above is basic information about the composition, uses, dosage and side effects of Zanedip 20mg medicine. In order to bring about the best treatment effect, patients and family members should carefully read the instructions for use of the drug Zanedip 20mg, and strictly follow the treatment instructions of the treating doctor.