Pipolphene side effects

Pipolphen medicine contains the active ingredient promethazine, which is effective in the prevention of allergies and even cases of hypersensitivity. In addition, the drug is also used in cases of sedation before, during obstetric surgery... Besides, the drug also causes effects during use such as drowsiness, hypotension, reaction Allergic reactions, constipation.... This article will provide you with information as well as specific effects of Pipolphen.

What is Pipolphen? Pipolphen has an H1-receptor antihistamine effect that causes sedation, drowsiness, and anti-emetic states.
Promethazine can be well absorbed from the gastrointestinal tract and at the injection site. Promethazine drug concentration when entering the body and entering the blood plasma has antihistamine and sedative effects. However, this effect has not yet been clearly demonstrated. When pipolphen is administered orally to the rectum or can be used intramuscularly, the drug begins to have an antihistamine and sedative effect within about 20 minutes. As for the case of intravenous injection, it only takes about 3 to 5 minutes.
When the compound Promethazine enters the body, the rate of binding to plasma proteins will be about 76 to 93%. At the same time, the drug will be widely distributed to tissues in the body. Although concentrations of the drug are lower in the brain than in other organs of the body, these concentrations are still higher than those in plasma. For pregnant women, when the drug enters the body, it will easily cross the placenta. However, there is no evidence of the distribution of the drug in breast milk.
When Promethazine compounds enter the body, they will be strongly metabolized in the liver and produce mainly promethazine sulphoxide and N-dimethyl promethazine. After entering the body, the drug is eliminated via urine, feces, and compounds are excreted mainly in the form of promethazine sulphoxide and glucuronide form.
Promethazine when entering the body has antiemetic, or anticholinergic effects, or against motion sickness or local numbness. Furthermore, the drug has a mild antitussive effect or may reflect a potential for respiratory depression. In addition, Promethazine also acts as an H1-receptor blocker by competing with histamine for H1-receptor sites on effector cells. However, it is unlikely to block histamine release. Therefore, the drug Pipolphen is only able to block the reaction caused by histamine.

What is Pipolphene? The drug is effective in the treatment of allergic or anaphylactoid reactions, or sedation before, during and after obstetric-related surgery. At the same time, Pipolphen has the effect of increasing the potency of anesthetic drugs, or reducing pain to help prevent and control nausea and vomiting caused by anesthesia after surgery or motion sickness.

For adults using pipolphen for allergy or anaphylaxis, the dose is 12.5 mg each time and used 3 to 4 times a day or can use a dose of 25mg in the evening during treatment. treatment.
For adults, using the usual dose for sedation before, after surgery and in obstetrics can increase the potency of the anesthetic as well as analgesia. The dose used in this case is usually 50 mg 2.5 hours before surgery and can be repeated after 1 hour.
For adults, use the usual dose to prevent and control vomiting, nausea due to anesthesia or after surgery. Doses of 25 mg or 12.5 mg to 25.g may be used every 4 to 6 hours.
In the case of adults using the usual dose for motion sickness, a dose of 25mg can be used twice a day. It should be taken 30 minutes to 1 hour before driving and repeated every 8 to 12 hours if needed and used up to a maximum dose of 15mg per day.
Before using the drug pipolphen you should consult your doctor and learn more about how to use the medicine listed on the drug label. When using the drug, it is necessary to strictly follow the doctor's instructions, do not increase or decrease the dose arbitrarily compared to the prescribed dose. Or do not arbitrarily stop using the drug without the permission of the doctor.
When using pipolphen, if an overdose occurs, you can call an ambulance or immediately go to a local medical facility near your place of residence for timely treatment. In addition, the patient also needs to record or bring a list of drugs that he has ever used including prescription and non-prescription so that the doctor can diagnose and handle it properly. The management of emergency situations, pipolphen overdose should focus on treating the symptoms of the situation while applying supportive measures to the necessary situation as well as monitoring muscle function. body during treatment.

The drug pipolphen is sometimes contraindicated in certain cases such as related to coma, or patients who are taking large doses of central nervous system depressants such as alcohol, sedatives or narcotics or The patient is taking antipsychotics.
In some cases, the use of pipolphen will be possible to experience side effects such as: drowsiness, blurred vision, or changes in blood pressure that may increase or decrease after injection, or rash. Occasionally, dizziness, fatigue, ringing in the ears, or insomnia may occur. Some people also experience dry mouth or throat, nausea or possibly vomiting, burning sensation and pain in the rectum.
Treatment in case of side effects when using pipolphen: In adults, lethargy or coma, sometimes with seizures or hypotension, can treat the symptoms. By helping the patient to lie in a position of ventilation, induce vomiting in the patient to eliminate the dose. However, when performing it, it is necessary to take precautions and be careful to avoid choking, especially for children. Can use activated charcoal or salt bleach, gastric lavage for patients if not stimulate vomiting. In cases where seizures occur, diazepam or barbiturates may be used to control the condition. Severe external pyramidal reactions can be treated with anticholinergics and antiparkinsonian drugs...