Learn about macrolide antibiotics

Macrolide is a group of antibiotics with a lactone ring of 12 to 17 carbon atoms or is used in treatment with the drug name erythromycin. Currently, on the market, this group of drugs has a lot of very popular oral brand names that are often indicated for the treatment of respiratory tract infections (pneumonia, bronchitis), skin and soft tissue infections...
Classification according to chemical structure characteristics, Macrolide antibiotics can be divided into 3 groups:
Chain structure of 14 carbon atoms: Erythromycin, Oleandomycin, Roxithromycin, Clarithromycin, Diritromycin. 15-carbon structure: Azithromycin. 16-carbon structure: Spiramycin, Josamycin. The natural origin used to prepare macrolides is mainly from the culture of streptomyces bacteria. As for the semi-synthetic antibiotics, the manufacturers took from natural macrolides and changed some substituents to overcome the disadvantages of the original macrolides such as roxithromycin, clarithromycin, azithromycin... Derived from erythromycin, when By changing the substituents, it is possible to create products that are more stable in acidic media, improve bioavailability (increasing absorption through the small intestine) and broaden the spectrum of action against bacteria.

Antibiotics of this group are well distributed in tissues, especially bones and bronchial fluid. For bacteria that are already resistant to penicillin, macrolides are the antibiotic of choice to replace them.
Macrolid mainly focuses on some strains of Gram-positive bacteria and some atypical bacteria (Clostridium Perfringens, Corynebacterium Diphtheriae, Listeria Monocytogenes).
The drug has no effect on most strains of Gram-negative bacilli in the intestine and only has a weak effect on some other strains of Gram-negative bacteria such as H. influenzae and N. meningitidis. However, it is an antibacterial drug. quite good on strains of N. Gonorrhoeae.
Macrolide group also has good antibacterial effect on intracellular bacteria such as Campylobacter jejuni, M. Pneumoniae, Legionella Pneumophila, C. Trachomatis, Mycobacteria (including M. Scrofulaceum, M. kansasii, M. Avium-Intracellulare – extrinsic) except M. Fortuitum).
Macrolide antibiotics are well distributed in tissues, especially bone and bronchial fluid. For bacteria that are already resistant to penicillin, macrolides are the antibiotic of choice to replace them. The most commonly used form of medicine is tablets and capsules for oral administration. The injectable form is for hospital use only. Attention should be paid to the potential for drug interactions, especially with antihistamines.

The first drug in the macrolide group is erythromycin, because of the short half-life of erythromycin, it must be taken several times a day. Therefore, the introduction of semi-synthetic macrolides has overcome this drawback. Erythromycin is used to treat respiratory diseases, diphtheria, pneumonia in children caused by atypical bacteria, neonatal conjunctivitis, used as an alternative to penicillin.
Roxithromycin (rulid): Treatment of diphtheria, whooping cough, pneumonia caused by Mycoplasma and legionella. Clarithromycin: Currently also very popular in combination with amoxicillin and metronidazole in the treatment regimen of peptic ulcers caused by Helicobacter Pylori (in addition to a proton pump inhibitor such as omeprazole). In addition, clarithromycin is also used to treat AIDS patients. Spiramycin (rovamycin): The drug tolerates acidic environments, is not toxic to the liver, and has a long half-life (6 - 8 hours). Currently on the market, there is a combination form with metronidazole (rodogyl) used to treat anaerobic infections, or used in oral and maxillofacial infections. Medicines used to treat infections of the respiratory tract, skin, and genitals. Azithromycin (zithromax): The drug penetrates heavily into tissues (except cerebrospinal fluid). The drug has a very broad spectrum of action and a long half-life (more than 70 hours) so it only needs to be taken once a day and 3 days in a course of treatment. Azithromycin is used to treat diseases caused by Legionella pneumophila, secondary syphilis, malaria, cholera, Lyme.

The macrolide antibiotic group is the most commonly used form of drug because the route of administration is mainly oral, the drug is well tolerated, can be used in pregnant women and is used in AIDS patients to treat opportunistic infections. This is a drug with many expensive brand names, so doctors need to consider carefully before using it to reduce the economic burden on patients.

The most common side effects of this group of antibiotics are on the gastrointestinal tract: nausea, vomiting, abdominal pain, diarrhea (when taken orally), thrombophlebitis (when administered intravenously). In particular, this group of antibiotics is strongly metabolized by the liver, so it can cause hepatitis or cholestasis. Other side effects such as skin allergy (skin rash, rash) or anaphylaxis have also been reported with this group of antibiotics.
No matter what health problems you have, when you are prescribed antibiotics, you need to be very careful, choose a reputable medical examination and treatment facility and especially do not abuse drugs to avoid antibiotic resistance.
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